Question 1

For what disease is the human monoclonal antibody Arzerra likely to be approved for treatment?

Accepted Answer

A) acute lymphocytic leukemia 
B) chronic lymphocytic leukemia 
C) ALS (Lou Gehrig's disease) 
D) multiple sclerosis 
E) glioblastoma 
A) acute lymphocytic leukemia 
B) chronic lymphocytic leukemia 
C) ALS (Lou Gehrig's disease) 
D) multiple sclerosis 
E) glioblastoma

Question 2

What evidence suggested that the elevated sensitivity of cancer cells to radiation therapy and chemotherapy was not due to their more rapid division?

Accepted Answer

A) Cells that divide more quickly reproduce more effectively. 
B) Some cancer cells divide more slowly than their normal counterparts,yet they are still more sensitive to drugs and radiation than are normal cells. 
C) Cells that divide more quickly reproduce less effectively. 
D) Some cancer cells divide more quickly than their normal counterparts,yet they are still more sensitive to drugs and radiation than are normal cells. 
E) Normal cells dividing more slowly than tumor cells are more sensitive to drugs and radiation. 
A) Cells that divide more quickly reproduce more effectively. 
B) Some cancer cells divide more slowly than their normal counterparts,yet they are still more sensitive to drugs and radiation than are normal cells. 
C) Cells that divide more quickly reproduce less effectively. 
D) Some cancer cells divide more quickly than their normal counterparts,yet they are still more sensitive to drugs and radiation than are normal cells. 
E) Normal cells dividing more slowly than tumor cells are more sensitive to drugs and radiation.

Question 3

What happens quite often to the number of normal receptors in the plasma membranes of malignant cells as compared to normal cells?

Accepted Answer

A) Malignant cells usually have the same number of receptors in their plasma membranes as normal cells. 
B) Malignant cells usually have a much larger number of plasma membrane receptors than normal cells. 
C) Malignant cells usually have a much smaller number of plasma membrane receptors than normal cells. 
D) Malignant cells usually have no plasma membrane receptors,while normal cells have them. 
E) None of these are correct. 
A) Malignant cells usually have the same number of receptors in their plasma membranes as normal cells. 
B) Malignant cells usually have a much larger number of plasma membrane receptors than normal cells. 
C) Malignant cells usually have a much smaller number of plasma membrane receptors than normal cells. 
D) Malignant cells usually have no plasma membrane receptors,while normal cells have them. 
E) None of these are correct.

Question 4

Chronic infection with what stomach-dwelling bacterium has been associated with certain gastric lymphomas?

Accepted Answer

A) Escherichia coli 
B) Staphylococcus aureus 
C) Helicobacter pylori 
D) Saccharomyces cerevisiae 
E) Helicopter stomachus 
A) Escherichia coli 
B) Staphylococcus aureus 
C) Helicobacter pylori 
D) Saccharomyces cerevisiae 
E) Helicopter stomachus

Question 5

If you could treat a tumor with an antibody against a factor that attracts blood vessels to the tumor,what might happen?

Accepted Answer

The antibody would interact with the fac

Question 6

Which screening test just being developed will be able to screen based on the relative levels of various proteins in the blood?

Accepted Answer

A) genomics 
B) Pap smear 
C) colonoscopy 
D) proteomics 
E) astronomics 
A) genomics 
B) Pap smear 
C) colonoscopy 
D) proteomics 
E) astronomics

Question 7

After the DNAs attached to the glass slide of a microarray are exposed to a probe,how are they usually visualized?

Accepted Answer

A) The cDNA probes are fluorescently labeled. 
B) The mRNA probes are fluorescently labeled. 
C) The cDNA probes are radioactively labeled. 
D) The cDNA probes are labeled with ferritin. 
E) The mRNA probes are labeled with ferritin. 
A) The cDNA probes are fluorescently labeled. 
B) The mRNA probes are fluorescently labeled. 
C) The cDNA probes are radioactively labeled. 
D) The cDNA probes are labeled with ferritin. 
E) The mRNA probes are labeled with ferritin.

Question 8

Mutant forms of tumor-suppressor genes act _____;both copies of the gene must be _______ before their protective function is lost.

Accepted Answer

A) as dominant Mendelian traits,mutated or deleted 
B) as dominant Mendelian traits,preserved 
C) recessively,mutated or deleted 
D) recessively,preserved 
E) like sex-linked recessive genes,mutated or deleted 
A) as dominant Mendelian traits,mutated or deleted 
B) as dominant Mendelian traits,preserved 
C) recessively,mutated or deleted 
D) recessively,preserved 
E) like sex-linked recessive genes,mutated or deleted

Question 9

Which of the following is a biomarker that may at some point could reveal the presence of cancer through a blood test or screening?

Accepted Answer

A) mutant DNA 
B) abnormal carbohydrates 
C) distinctive metabolites 
D) presence of cancer cells 
E) All of these are correct. 
A) mutant DNA 
B) abnormal carbohydrates 
C) distinctive metabolites 
D) presence of cancer cells 
E) All of these are correct.

Question 10

How does the behavior of the altered receptor that is the product of the avian erythroblastosis virus differ from the wild type form of the receptor?

Accepted Answer

A) The altered receptor behaves in the same way as the wild-type receptor. 
B) The altered receptor constitutively stimulates cell growth in the presence and absence of the growth factor. 
C) The altered receptor stimulates cell growth in the presence of the growth factor,but not in its absence. 
D) The altered receptor constitutively represses growth and cell proliferation in the presence and absence of the growth factor. 
E) The altered receptor stimulates cell growth in the absence of the growth factor,but not in its presence. 
A) The altered receptor behaves in the same way as the wild-type receptor. 
B) The altered receptor constitutively stimulates cell growth in the presence and absence of the growth factor. 
C) The altered receptor stimulates cell growth in the presence of the growth factor,but not in its absence. 
D) The altered receptor constitutively represses growth and cell proliferation in the presence and absence of the growth factor. 
E) The altered receptor stimulates cell growth in the absence of the growth factor,but not in its presence.

Question 11

Patients suffering from familial adenomatous polyposis coli have typically been found to have _________,which is the site of the _________.

Accepted Answer

A) a small chromosome 15 deletion,RP tumor-suppressor gene 
B) a small chromosome 5 deletion,APC oncogene 
C) a small chromosome 5 duplication,APC tumor-suppressor gene 
D) a small chromosome 5 deletion,APC tumor-suppressor gene 
E) a small chromosome 6 deletion,APC tumor-suppressor gene 
A) a small chromosome 15 deletion,RP tumor-suppressor gene 
B) a small chromosome 5 deletion,APC oncogene 
C) a small chromosome 5 duplication,APC tumor-suppressor gene 
D) a small chromosome 5 deletion,APC tumor-suppressor gene 
E) a small chromosome 6 deletion,APC tumor-suppressor gene

Question 12

What part of the cell cycle does the pRB protein help to regulate?

Accepted Answer

A) the S - G2 transition 
B) the G1 - S transition 
C) the G2 - M transition 
D) the G0 - G1 transition 
E) the M - G2 transition 
A) the S - G2 transition 
B) the G1 - S transition 
C) the G2 - M transition 
D) the G0 - G1 transition 
E) the M - G2 transition

Question 13

Judah Folkmann suggested that solid tumors __________.

Accepted Answer

A) might be destroyed by enhancing their ability to form new blood vessels 
B) might be dissipated by enhancing the ability of cancer cells to separate from each other 
C) might be destroyed by inhibiting their ability to form new blood vessels 
D) might be enlarged by breaking down neighboring tissues 
E) might be desiccated by osmotic action 
A) might be destroyed by enhancing their ability to form new blood vessels 
B) might be dissipated by enhancing the ability of cancer cells to separate from each other 
C) might be destroyed by inhibiting their ability to form new blood vessels 
D) might be enlarged by breaking down neighboring tissues 
E) might be desiccated by osmotic action

Question 14

What is the most important property of a cancer cell,whether it is in the body or the culture dish?

Accepted Answer

A) its chromosome complement 
B) its loss of growth control 
C) its size 
D) its secretions 
E) its inability to divide 
A) its chromosome complement 
B) its loss of growth control 
C) its size 
D) its secretions 
E) its inability to divide

Question 15

The cancer vaccine GRNVAC1 has been designed to teach a person's immune cells to attack what enzyme?

Accepted Answer

A) prostatic acid phosphatase 
B) alkaline phosphatase 
C) catalase 
D) telomerase 
E) reverse transcriptase 
A) prostatic acid phosphatase 
B) alkaline phosphatase 
C) catalase 
D) telomerase 
E) reverse transcriptase

Question 16

A single layer of cells that covers a culture dish is called a(n)_________.

Accepted Answer

A) duolayer 
B) imperium 
C) monolayer 
D) unolayer 
E) Unitarian 
A) duolayer 
B) imperium 
C) monolayer 
D) unolayer 
E) Unitarian

Question 17

William Coley,a New York physician in the late 1800s,studied spontaneous remissions of terminal cancer cases.He read that one man,who had an inoperable neck tumor,had gone into remission after what event?

Accepted Answer

A) after a cold 
B) after changing his diet drastically 
C) after a streptococcal infection beneath his skin 
D) after a rigorous exercise regimen 
E) after taking multiple vitamins 
A) after a cold 
B) after changing his diet drastically 
C) after a streptococcal infection beneath his skin 
D) after a rigorous exercise regimen 
E) after taking multiple vitamins

Question 18

How are drug companies trying to combat the ability of the BCL-2 gene to lower the effectiveness of chemotherapy?

Accepted Answer

A) They are trying to develop drugs that stabilize cancer cells. 
B) They are trying to develop drugs that make cancer cells more likely to undergo apoptosis. 
C) They are trying to develop drugs that cause cancer cells to revert to normal embryonic cells. 
D) They are trying to develop drugs that cause cancer cells to dedifferentiate. 
E) They are trying to develop drugs that cause cancer cells to differentiate. 
A) They are trying to develop drugs that stabilize cancer cells. 
B) They are trying to develop drugs that make cancer cells more likely to undergo apoptosis. 
C) They are trying to develop drugs that cause cancer cells to revert to normal embryonic cells. 
D) They are trying to develop drugs that cause cancer cells to dedifferentiate. 
E) They are trying to develop drugs that cause cancer cells to differentiate.

Question 19

About 25% of breast cancers are composed of cells that overexpress the HER2 gene.What property does the overexpression of this gene confer upon the tumor cells?

Accepted Answer

A) The tumor cells are more responsive to Herceptin stimulation in the body. 
B) The tumor cells are less responsive to Herceptin stimulation. 
C) The tumor cells are more likely to undergo apoptosis. 
D) These cells are especially sensitive to growth factor stimulation. 
E) These cells are especially resistant to growth factor stimulation. 
A) The tumor cells are more responsive to Herceptin stimulation in the body. 
B) The tumor cells are less responsive to Herceptin stimulation. 
C) The tumor cells are more likely to undergo apoptosis. 
D) These cells are especially sensitive to growth factor stimulation. 
E) These cells are especially resistant to growth factor stimulation.

Question 20

_____________ is an inherited disease in which individuals develop many (hundreds or thousands)of premalignant polyps from epithelial cells lining the colon wall.

Accepted Answer

A) Familial adenomatous polyposis coli 
B) Familial hypercholesterolemia 
C) Inherited adenomitis 
D) Familial polypsoidemia 
E) Inherited polypoma intestines 
A) Familial adenomatous polyposis coli 
B) Familial hypercholesterolemia 
C) Inherited adenomitis 
D) Familial polypsoidemia 
E) Inherited polypoma intestines

For what disease is the human monoclonal antibody Arzerra likely to be approved for treatment?

What evidence suggested that the elevated sensitivity of cancer cells to radiation therapy and chemotherapy was not due to their more rapid division?

What happens quite often to the number of normal receptors in the plasma membranes of malignant cells as compared to normal cells?

Chronic infection with what stomach-dwelling bacterium has been associated with certain gastric lymphomas?

If you could treat a tumor with an antibody against a factor that attracts blood vessels to the tumor,what might happen?

Which screening test just being developed will be able to screen based on the relative levels of various proteins in the blood?

After the DNAs attached to the glass slide of a microarray are exposed to a probe,how are they usually visualized?

Mutant forms of tumor-suppressor genes act _;both copies of the gene must be ___ before their protective function is lost.

Which of the following is a biomarker that may at some point could reveal the presence of cancer through a blood test or screening?

How does the behavior of the altered receptor that is the product of the avian erythroblastosis virus differ from the wild type form of the receptor?

Patients suffering from familial adenomatous polyposis coli have typically been found to have _,which is the site of the _.

What part of the cell cycle does the pRB protein help to regulate?

Judah Folkmann suggested that solid tumors __________.

What is the most important property of a cancer cell,whether it is in the body or the culture dish?

The cancer vaccine GRNVAC1 has been designed to teach a person's immune cells to attack what enzyme?

A single layer of cells that covers a culture dish is called a(n)_________.

William Coley,a New York physician in the late 1800s,studied spontaneous remissions of terminal cancer cases.He read that one man,who had an inoperable neck tumor,had gone into remission after what event?

How are drug companies trying to combat the ability of the BCL-2 gene to lower the effectiveness of chemotherapy?

About 25% of breast cancers are composed of cells that overexpress the HER2 gene.What property does the overexpression of this gene confer upon the tumor cells?

_____________ is an inherited disease in which individuals develop many (hundreds or thousands)of premalignant polyps from epithelial cells lining the colon wall.

Introduction to the Study of Cell and Molecular Biology

The Chemical Basis of Life

Bioenergetics, Enzymes, and Metabolism

The Structure and Function of the Plasma Membrane

Aerobic Respiration and the Mitochondrion

Photosynthesis and the Chloroplast

Interactions Between Cells and Their Environment

Cytoplasmic Membrane Systems: Structure, Function, and Membrane Trafficking

The Cytoskeleton and Cell Motility

The Nature of the Gene and the Genome

Gene Expression: From Transcription to Translation

Control of Gene Expression

Dna Replication and Repair

Cellular Reproduction

Cell Signaling and Signal Transduction: Communication Between Cells

The Immune Response

Techniques in Cell and Molecular Biology

Filters

Exam 16: Cancer

For what disease is the human monoclonal antibody Arzerra likely to be approved for treatment?

What evidence suggested that the elevated sensitivity of cancer cells to radiation therapy and chemotherapy was not due to their more rapid division?

What happens quite often to the number of normal receptors in the plasma membranes of malignant cells as compared to normal cells?

Chronic infection with what stomach-dwelling bacterium has been associated with certain gastric lymphomas?

If you could treat a tumor with an antibody against a factor that attracts blood vessels to the tumor,what might happen?

Which screening test just being developed will be able to screen based on the relative levels of various proteins in the blood?

After the DNAs attached to the glass slide of a microarray are exposed to a probe,how are they usually visualized?

Mutant forms of tumor-suppressor genes act _____;both copies of the gene must be _______ before their protective function is lost.

Which of the following is a biomarker that may at some point could reveal the presence of cancer through a blood test or screening?

How does the behavior of the altered receptor that is the product of the avian erythroblastosis virus differ from the wild type form of the receptor?

Patients suffering from familial adenomatous polyposis coli have typically been found to have _________,which is the site of the _________.

What part of the cell cycle does the pRB protein help to regulate?

Judah Folkmann suggested that solid tumors __________.

What is the most important property of a cancer cell,whether it is in the body or the culture dish?

The cancer vaccine GRNVAC1 has been designed to teach a person's immune cells to attack what enzyme?

A single layer of cells that covers a culture dish is called a(n)_________.

William Coley,a New York physician in the late 1800s,studied spontaneous remissions of terminal cancer cases.He read that one man,who had an inoperable neck tumor,had gone into remission after what event?

How are drug companies trying to combat the ability of the BCL-2 gene to lower the effectiveness of chemotherapy?

About 25% of breast cancers are composed of cells that overexpress the HER2 gene.What property does the overexpression of this gene confer upon the tumor cells?

_____________ is an inherited disease in which individuals develop many (hundreds or thousands)of premalignant polyps from epithelial cells lining the colon wall.

Introduction to the Study of Cell and Molecular Biology

The Chemical Basis of Life

Bioenergetics, Enzymes, and Metabolism

The Structure and Function of the Plasma Membrane

Aerobic Respiration and the Mitochondrion

Photosynthesis and the Chloroplast

Interactions Between Cells and Their Environment

Cytoplasmic Membrane Systems: Structure, Function, and Membrane Trafficking

The Cytoskeleton and Cell Motility

The Nature of the Gene and the Genome

Gene Expression: From Transcription to Translation

Control of Gene Expression

Dna Replication and Repair

Cellular Reproduction

Cell Signaling and Signal Transduction: Communication Between Cells

The Immune Response

Techniques in Cell and Molecular Biology

Filters

Mutant forms of tumor-suppressor genes act _;both copies of the gene must be ___ before their protective function is lost.

Patients suffering from familial adenomatous polyposis coli have typically been found to have _,which is the site of the _.