Question 1

Explain the importance of serotonin reuptake-blocking drugs for the treatment of mental disorders.

Accepted Answer

Serotonin reuptake inhibitors block the serotonin transporter, thus allowing serotonin to remain in the synapse. These drugs are used clinically to treat depression, some anxiety disorders, and obsessive-compulsive disorder.

Question 2

The primary organ that metabolizes drugs is the

Accepted Answer

A)  liver. 
B)  lungs. 
C)  mucosa. 
D)  kidneys. 
E)  skin. 
A)  liver. 
B)  lungs. 
C)  mucosa. 
D)  kidneys. 
E)  skin. A

Question 3

The ________ route is commonly used to administer drugs to humans.

Accepted Answer

oral

Question 4

Drugs that block histamine receptors produce

Accepted Answer

A)  Parkinsonism. 
B)  delusions. 
C)  drowsiness. 
D)  REM sleep. 
E)  arousal. 
A)  Parkinsonism. 
B)  delusions. 
C)  drowsiness. 
D)  REM sleep. 
E)  arousal.

Question 5

Drugs that inactivate monoamine oxidase B would be expected to

Accepted Answer

A)  also block D2 receptors. 
B)  increase the release of dopamine in response to the arrival of an action potential at the terminal buttons. 
C)  make the dopamine transporter run in reverse. 
D)  cause the release of serotonin into the synaptic cleft. 
E)  increase the release of acetylcholine in response to the arrival of an action potential at the terminal buttons. 
A)  also block D2 receptors. 
B)  increase the release of dopamine in response to the arrival of an action potential at the terminal buttons. 
C)  make the dopamine transporter run in reverse. 
D)  cause the release of serotonin into the synaptic cleft. 
E)  increase the release of acetylcholine in response to the arrival of an action potential at the terminal buttons.

Question 6

All peptides studied so far are produced from

Accepted Answer

A)  enzymes. 
B)  polypeptides. 
C)  vesicles. 
D)  precursor molecules. 
E)  postcursor molecules. 
A)  enzymes. 
B)  polypeptides. 
C)  vesicles. 
D)  precursor molecules. 
E)  postcursor molecules.

Question 7

Termination of the postsynaptic potential would be expected from a drug or process that acts to

Accepted Answer

A)  increase synthesis of the neurotransmitter molecule. 
B)  enzymatically degrade the neurotransmitter molecule. 
C)  blocks transport of the neurotransmitter molecule through the axon membrane. 
D)  increase the number of postsynaptic receptors. 
E)  increase release of the neurotransmitter. 
A)  increase synthesis of the neurotransmitter molecule. 
B)  enzymatically degrade the neurotransmitter molecule. 
C)  blocks transport of the neurotransmitter molecule through the axon membrane. 
D)  increase the number of postsynaptic receptors. 
E)  increase release of the neurotransmitter.

Question 8

Compare and contrast 2 routes of administration of drugs. What are benefits and drawbacks of each?

Accepted Answer

Answers: will vary depending on choice.

Question 9

Nicotinic receptors are found in ________ in the periphery and in ________ in the brain.

Accepted Answer

A)  cardiac fibers; glial cells 
B)  muscle fibers; axoaxonic synapses 
C)  the pupils; axoaxonic synapses 
D)  cardiac fibers; axodendritic synapses 
E)  the lungs; axodendritic synapses 
A)  cardiac fibers; glial cells 
B)  muscle fibers; axoaxonic synapses 
C)  the pupils; axoaxonic synapses 
D)  cardiac fibers; axodendritic synapses 
E)  the lungs; axodendritic synapses

Question 10

Activation of dendritic autoreceptors produce ________; a drug that is an agonist at these autoreceptors would be classified as an ________ for the synapse.

Accepted Answer

A)  depolarizations; antagonist 
B)  hyperpolarizations; agonist 
C)  hyperpolarizations; indirect agonist 
D)  hyperpolarizations; antagonist 
E)  action potentials; agonist 
A)  depolarizations; antagonist 
B)  hyperpolarizations; agonist 
C)  hyperpolarizations; indirect agonist 
D)  hyperpolarizations; antagonist 
E)  action potentials; agonist

Question 11

The postsynaptic action of acetylcholine is terminated by

Accepted Answer

A)  reuptake of choline into the presynaptic terminal. 
B)  reuptake of acetylcholine into the presynaptic terminal. 
C)  enzymatic destruction via acetylcholinesterase. 
D)  diffusion away from the synapse. 
E)  reduced synthesis of acetylcholine. 
A)  reuptake of choline into the presynaptic terminal. 
B)  reuptake of acetylcholine into the presynaptic terminal. 
C)  enzymatic destruction via acetylcholinesterase. 
D)  diffusion away from the synapse. 
E)  reduced synthesis of acetylcholine.

Question 12

Which of the following is an incorrect match between a neurotransmitter and its effects?

Accepted Answer

A)  glutamate; generally excitatory in the brain 
B)  acetylcholine; activates the cortex and facilitates learning 
C)  glycine; generally inhibitory in the brain 
D)  glutamate; released by all sensory neurons 
E)  acetylcholine; subject to reuptake by the axon terminals 
A)  glutamate; generally excitatory in the brain 
B)  acetylcholine; activates the cortex and facilitates learning 
C)  glycine; generally inhibitory in the brain 
D)  glutamate; released by all sensory neurons 
E)  acetylcholine; subject to reuptake by the axon terminals

Question 13

Which of the following is a correct match between a drug and its effect on GABA function?

Accepted Answer

A)  muscimol; agonist at the GABAB receptor 
B)  picrotoxin; indirect antagonist of the GABAA receptor 
C)  diazepam; reduces the activity of GABAA receptors 
D)  baclofen; antagonist at the GABAA receptor 
E)  nicotine; agonist at the GABAA receptor 
A)  muscimol; agonist at the GABAB receptor 
B)  picrotoxin; indirect antagonist of the GABAA receptor 
C)  diazepam; reduces the activity of GABAA receptors 
D)  baclofen; antagonist at the GABAA receptor 
E)  nicotine; agonist at the GABAA receptor

Question 14

Peptides, unlike neurotransmitters, are always

Accepted Answer

A)  destroyed by enzymes. 
B)  taken back up into the presynaptic cell via transporters. 
C)  recycled and reused. 
D)  allowed to remain in the cleft indefinitely. 
E)  not recycled. 
A)  destroyed by enzymes. 
B)  taken back up into the presynaptic cell via transporters. 
C)  recycled and reused. 
D)  allowed to remain in the cleft indefinitely. 
E)  not recycled.

Question 15

The drug ________ causes pupil dilation by blocking ________ receptors.

Accepted Answer

A)  cocaine; dopaminergic 
B)  atropine; muscarinic 
C)  curare; muscarinic 
D)  belladona; adrenergic 
E)  muscarine; nicotinic 
A)  cocaine; dopaminergic 
B)  atropine; muscarinic 
C)  curare; muscarinic 
D)  belladona; adrenergic 
E)  muscarine; nicotinic

Question 16

The hallucinatory drug PCP (phencyclidine)

Accepted Answer

A)  is an antagonist of the NMDA receptor. 
B)  facilitates the binding of glutamate to the AMPA receptor. 
C)  releases serotonin from neurons in the raphe nuclei. 
D)  inhibits the dendrites of dopamine neurons in the ventral tegmental area. 
E)  acts via the blockade of serotonin receptors. 
A)  is an antagonist of the NMDA receptor. 
B)  facilitates the binding of glutamate to the AMPA receptor. 
C)  releases serotonin from neurons in the raphe nuclei. 
D)  inhibits the dendrites of dopamine neurons in the ventral tegmental area. 
E)  acts via the blockade of serotonin receptors.

Question 17

A drug that binds at a postsynaptic site different from that of the neurotransmitter and facilitates the opening of ion channels would be termed a(n)

Accepted Answer

A)  indirect antagonist. 
B)  ligand. 
C)  direct synergist. 
D)  indirect agonist. 
E)  inducer. 
A)  indirect antagonist. 
B)  ligand. 
C)  direct synergist. 
D)  indirect agonist. 
E)  inducer.

Question 18

________ is a cannabinoid receptor agonist that increases appetite and produces analgesia.

Accepted Answer

The answer of ________ is a cannabinoid receptor agonist that...

Question 19

What is the advantage of reuptake over enzymatic degradation in the termination of neurotransmitter postsynaptic effects?

Accepted Answer

Reuptake transports the neurotransmitter

Question 20

The ________ route of drug administration has the advantage of bypassing the blood-brain barrier.

Accepted Answer

A)  intraperitoneal 
B)  oral 
C)  intravascular 
D)  topical 
E)  intracerebroventricular 
A)  intraperitoneal 
B)  oral 
C)  intravascular 
D)  topical 
E)  intracerebroventricular

Explain the importance of serotonin reuptake-blocking drugs for the treatment of mental disorders.

The primary organ that metabolizes drugs is the

The ________ route is commonly used to administer drugs to humans.

Drugs that block histamine receptors produce

Drugs that inactivate monoamine oxidase B would be expected to

All peptides studied so far are produced from

Termination of the postsynaptic potential would be expected from a drug or process that acts to

Compare and contrast 2 routes of administration of drugs. What are benefits and drawbacks of each?

Nicotinic receptors are found in in the periphery and in in the brain.

Activation of dendritic autoreceptors produce ; a drug that is an agonist at these autoreceptors would be classified as an for the synapse.

The postsynaptic action of acetylcholine is terminated by

Which of the following is an incorrect match between a neurotransmitter and its effects?

Which of the following is a correct match between a drug and its effect on GABA function?

Peptides, unlike neurotransmitters, are always

The drug causes pupil dilation by blocking receptors.

The hallucinatory drug PCP (phencyclidine)

A drug that binds at a postsynaptic site different from that of the neurotransmitter and facilitates the opening of ion channels would be termed a(n)

________ is a cannabinoid receptor agonist that increases appetite and produces analgesia.

What is the advantage of reuptake over enzymatic degradation in the termination of neurotransmitter postsynaptic effects?

The ________ route of drug administration has the advantage of bypassing the blood-brain barrier.

Introduction

Structure and Function of Cells of the Nervous System

Structure of the Nervous System

Methods and Strategies of Research

Vision

Audition, the Body Senses, and the Chemical Senses

Control of Movement

Sleep and Biological Rhythms

Reproductive Behavior

Emotion

Ingestive Behavior

Learning and Memory

Human Communication

Neurological Disorders

Schizophrenia and the Affective Disorders

Anxiety Disorders, Autistic Disorder, attention-Deficithyperactivity Disorder, and Stress Disorders

Substance Abuse

Filters

Exam 4: Psychopharmacology

Explain the importance of serotonin reuptake-blocking drugs for the treatment of mental disorders.

The primary organ that metabolizes drugs is the

The ________ route is commonly used to administer drugs to humans.

Drugs that block histamine receptors produce

Drugs that inactivate monoamine oxidase B would be expected to

All peptides studied so far are produced from

Termination of the postsynaptic potential would be expected from a drug or process that acts to

Compare and contrast 2 routes of administration of drugs. What are benefits and drawbacks of each?

Nicotinic receptors are found in ________ in the periphery and in ________ in the brain.

Activation of dendritic autoreceptors produce ________; a drug that is an agonist at these autoreceptors would be classified as an ________ for the synapse.

The postsynaptic action of acetylcholine is terminated by

Which of the following is an incorrect match between a neurotransmitter and its effects?

Which of the following is a correct match between a drug and its effect on GABA function?

Peptides, unlike neurotransmitters, are always

The drug ________ causes pupil dilation by blocking ________ receptors.

The hallucinatory drug PCP (phencyclidine)

A drug that binds at a postsynaptic site different from that of the neurotransmitter and facilitates the opening of ion channels would be termed a(n)

________ is a cannabinoid receptor agonist that increases appetite and produces analgesia.

What is the advantage of reuptake over enzymatic degradation in the termination of neurotransmitter postsynaptic effects?

The ________ route of drug administration has the advantage of bypassing the blood-brain barrier.

Introduction

Structure and Function of Cells of the Nervous System

Structure of the Nervous System

Methods and Strategies of Research

Vision

Audition, the Body Senses, and the Chemical Senses

Control of Movement

Sleep and Biological Rhythms

Reproductive Behavior

Emotion

Ingestive Behavior

Learning and Memory

Human Communication

Neurological Disorders

Schizophrenia and the Affective Disorders

Anxiety Disorders, Autistic Disorder, attention-Deficithyperactivity Disorder, and Stress Disorders

Substance Abuse

Filters

Nicotinic receptors are found in in the periphery and in in the brain.

Activation of dendritic autoreceptors produce ; a drug that is an agonist at these autoreceptors would be classified as an for the synapse.

The drug causes pupil dilation by blocking receptors.