Question 1

Combining antidepressants from different classes in the treatment of depression

Accepted Answer

A) has been shown to have no value 
B) may be useful in certain patients 
C) should be done in most patients 
D) none of these 
A) has been shown to have no value 
B) may be useful in certain patients 
C) should be done in most patients 
D) none of these

Question 2

Fluoxetine (Prozac) has been shown to

Accepted Answer

A) be significantly better at relieving the symptoms of depression than tricyclic antidepressants 
B) produce less disturbing side effects than those common to tricyclic antidepressants 
C) induce suicidal thoughts in a high percentage of depressed people 
D) all of the above 
A) be significantly better at relieving the symptoms of depression than tricyclic antidepressants 
B) produce less disturbing side effects than those common to tricyclic antidepressants 
C) induce suicidal thoughts in a high percentage of depressed people 
D) all of the above

Question 3

Antipsychotics (both conventional and atypical) are most appropriately used in the treatment of bipolar disorders

Accepted Answer

A) when patients are exhibiting symptoms of severe depression 
B) at the beginning of drug treatment when patients are exhibiting symptoms of mania 
C) after manic symptoms have been reduced with lithium, in order to prevent a subsequent switch into depression 
D) none of the above would be appropriate 
A) when patients are exhibiting symptoms of severe depression 
B) at the beginning of drug treatment when patients are exhibiting symptoms of mania 
C) after manic symptoms have been reduced with lithium, in order to prevent a subsequent switch into depression 
D) none of the above would be appropriate

Question 4

This neurotransmitter has also been implicated in affective disorders.This is supported by the clinical finding that physostigmine may aggravate depression and reduce mania.

Accepted Answer

A) acetylcholine 
B) serotonin 
C) norepinephrine 
D) GABA 
A) acetylcholine 
B) serotonin 
C) norepinephrine 
D) GABA

Question 5

Recent evidence suggests that monoamine oxidase inhibitors have the greatest efficacy in the treatment of

Accepted Answer

A) atypical depressions 
B) schizophrenics 
C) manic patients 
D) bipolar depressives 
A) atypical depressions 
B) schizophrenics 
C) manic patients 
D) bipolar depressives

Question 6

The monoamine reuptake blocking properties of the tricyclic antidepressants occur ________________________ their mood elevating properties are evidenced.

Accepted Answer

A) long before 
B) shortly before 
C) shortly after 
D) at about the same time as 
A) long before 
B) shortly before 
C) shortly after 
D) at about the same time as

Question 7

Support for the hypothesis that deficiencies in monoaminergic neuronal systems result in depression come from observations that

Accepted Answer

A) reserpine, which can reduce monoamine levels in the brain, may induce symptoms of depression. 
B) the time-course of symptom remission in depressed individuals treated with most antidepressants correlates almost perfectly with the time-course of these drugs' pharmacodynamic actions of inhibiting serotonin or norepinephrine reuptake or inhibiting monoamine oxidase activity. 
C) virtually all healthy adults, i.e., those with no history of depression personally or within their family, will exhibit the core symptoms of depression upon being administered treatments that reduce the levels of serotonin or norepinephrine in the brain. 
D) all of these 
A) reserpine, which can reduce monoamine levels in the brain, may induce symptoms of depression. 
B) the time-course of symptom remission in depressed individuals treated with most antidepressants correlates almost perfectly with the time-course of these drugs' pharmacodynamic actions of inhibiting serotonin or norepinephrine reuptake or inhibiting monoamine oxidase activity. 
C) virtually all healthy adults, i.e., those with no history of depression personally or within their family, will exhibit the core symptoms of depression upon being administered treatments that reduce the levels of serotonin or norepinephrine in the brain. 
D) all of these

Question 8

According to the monoamine deficiency hypothesis of depression, a drug that desensitizes monoamine autoreceptors would be predicted to

Accepted Answer

A) depress mood 
B) enhance mood in depressed people 
C) have no effect on mood 
A) depress mood 
B) enhance mood in depressed people 
C) have no effect on mood

Question 9

The use of tricyclic antidepressants for the treatment of depression in the elderly would generally not recommended primarily because of these drugs'

Accepted Answer

A) antiadrenergic-related side effects 
B) antidopaminergic-related side effects 
C) cardiovascular side effects 
D) antiserotonergic-related side effects 
A) antiadrenergic-related side effects 
B) antidopaminergic-related side effects 
C) cardiovascular side effects 
D) antiserotonergic-related side effects

Question 10

The rapid onset of severe hypertension upon ingesting certain foods is most likely to occur when a person is being treated with

Accepted Answer

A) tricyclic antidepressants 
B) buproprion 
C) serotonin uptake inhibitors 
D) monoamine oxidase inhibitors 
A) tricyclic antidepressants 
B) buproprion 
C) serotonin uptake inhibitors 
D) monoamine oxidase inhibitors

Question 11

Depression in unipolar disorder and bipolar disorder may be confused during diagnosis.What potential problems might occur if the decision was made to treat a person with bipolar depression with a standard antidepressant (e.g., tricyclic, SSRI) or to treat a person with unipolar depression with lithium?

Accepted Answer

The likelihood that the drug will be eff

Question 12

Give two pieces of evidence that support the monoamine hypothesis of depression and one piece of evidence that seems to conflict with the hypothesis.

Accepted Answer

The actions and behavioral effects of re

Question 13

The "neurotrophic" theory of antidepressant efficacy proposes that antidepressants work by

Accepted Answer

A) enhancing neurotrophic factors that reverse stress-induced damage to various brain regions 
B) enhancing the neurotransmission between monoamine-releasing neurons and other neurons 
C) reversing the deleterious effects of monoamines on neuronal architecture. 
A) enhancing neurotrophic factors that reverse stress-induced damage to various brain regions 
B) enhancing the neurotransmission between monoamine-releasing neurons and other neurons 
C) reversing the deleterious effects of monoamines on neuronal architecture.

Question 14

Lithium carbonate is used primarily for the treatment of

Accepted Answer

A) depression 
B) bipolar disorder 
C) anxiety 
D) schizophrenia 
A) depression 
B) bipolar disorder 
C) anxiety 
D) schizophrenia

Question 15

What is the relative efficacy of antidepressant drug therapy for adults diagnosed with clinical depression?

Accepted Answer

Individual medications within the catego

Question 16

The FDA has recently required drug companies to provide warnings on the labels of all antidepressants because of evidence that these drugs may induce

Accepted Answer

A) suicidal ideation or behaviors in a small proportion of depressed patients at the beginning of their treatment 
B) parkinsonian-like symptoms in elderly patients 
C) hypertensive crises when combined with certain foods or other drugs 
D) convulsions in certain patients 
A) suicidal ideation or behaviors in a small proportion of depressed patients at the beginning of their treatment 
B) parkinsonian-like symptoms in elderly patients 
C) hypertensive crises when combined with certain foods or other drugs 
D) convulsions in certain patients

Question 17

Which of the following phenomena is supportive of the neurotrophic theory of major depression?

Accepted Answer

A) depressive symptoms are gradually reduced with effective treatments for depression 
B) there is a sudden reoccurrence of depressive symptoms when depletions of serotonin or norepinephrine occur in depressed patients whose symptoms have been successfully treated with antidepressants 
C) the hippocampus and prefrontal cortices of depressed patients are significantly larger than in normal individuals 
A) depressive symptoms are gradually reduced with effective treatments for depression 
B) there is a sudden reoccurrence of depressive symptoms when depletions of serotonin or norepinephrine occur in depressed patients whose symptoms have been successfully treated with antidepressants 
C) the hippocampus and prefrontal cortices of depressed patients are significantly larger than in normal individuals

Question 18

The most significant problem associated with the use of lithium in the treatment of affective disorders is

Accepted Answer

A) its low therapeutic index 
B) its tendency to be toxic to the liver 
C) its expense as a prescription medication 
D) the requirement of maintaining low sodium intake for it to be effective 
A) its low therapeutic index 
B) its tendency to be toxic to the liver 
C) its expense as a prescription medication 
D) the requirement of maintaining low sodium intake for it to be effective

Combining antidepressants from different classes in the treatment of depression

Fluoxetine (Prozac) has been shown to

Antipsychotics (both conventional and atypical) are most appropriately used in the treatment of bipolar disorders

This neurotransmitter has also been implicated in affective disorders.This is supported by the clinical finding that physostigmine may aggravate depression and reduce mania.

Recent evidence suggests that monoamine oxidase inhibitors have the greatest efficacy in the treatment of

The monoamine reuptake blocking properties of the tricyclic antidepressants occur ________________________ their mood elevating properties are evidenced.

Support for the hypothesis that deficiencies in monoaminergic neuronal systems result in depression come from observations that

According to the monoamine deficiency hypothesis of depression, a drug that desensitizes monoamine autoreceptors would be predicted to

The use of tricyclic antidepressants for the treatment of depression in the elderly would generally not recommended primarily because of these drugs'

The rapid onset of severe hypertension upon ingesting certain foods is most likely to occur when a person is being treated with

Give two pieces of evidence that support the monoamine hypothesis of depression and one piece of evidence that seems to conflict with the hypothesis.

The "neurotrophic" theory of antidepressant efficacy proposes that antidepressants work by

Lithium carbonate is used primarily for the treatment of

What is the relative efficacy of antidepressant drug therapy for adults diagnosed with clinical depression?

The FDA has recently required drug companies to provide warnings on the labels of all antidepressants because of evidence that these drugs may induce

Which of the following phenomena is supportive of the neurotrophic theory of major depression?

The most significant problem associated with the use of lithium in the treatment of affective disorders is

Psychopharmacology in Perspective

Drug Classification and Behavioral Assessment

Basic Principles of Pharmacology

Excitability and Chemical Signaling in Nerve Cells

Synaptic Transmission, Drugs, and Chemical Neuroanatomy

Tolerance, Sensitization, Dependence, and Addiction

Psychomotor Stimulants and Antiparkinsonian Drugs

Antipsychotic Drugs and Neurochemical Hypotheses of Schizophrenia

Sedative-Hypnotics, Anxiolytics, and Anticonvulsants

Drug Treatment of Cognitive Dysfunction

Naturally Occurring and Synthetic Opiates and Their Antagonists

Dissociative Anesthetics

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Exam 9: Antidepressants and Mood Stabilizers

Combining antidepressants from different classes in the treatment of depression

Fluoxetine (Prozac) has been shown to

Antipsychotics (both conventional and atypical) are most appropriately used in the treatment of bipolar disorders

This neurotransmitter has also been implicated in affective disorders.This is supported by the clinical finding that physostigmine may aggravate depression and reduce mania.

Recent evidence suggests that monoamine oxidase inhibitors have the greatest efficacy in the treatment of

The monoamine reuptake blocking properties of the tricyclic antidepressants occur ________________________ their mood elevating properties are evidenced.

Support for the hypothesis that deficiencies in monoaminergic neuronal systems result in depression come from observations that

According to the monoamine deficiency hypothesis of depression, a drug that desensitizes monoamine autoreceptors would be predicted to

The use of tricyclic antidepressants for the treatment of depression in the elderly would generally not recommended primarily because of these drugs'

The rapid onset of severe hypertension upon ingesting certain foods is most likely to occur when a person is being treated with

Give two pieces of evidence that support the monoamine hypothesis of depression and one piece of evidence that seems to conflict with the hypothesis.

The "neurotrophic" theory of antidepressant efficacy proposes that antidepressants work by

Lithium carbonate is used primarily for the treatment of

What is the relative efficacy of antidepressant drug therapy for adults diagnosed with clinical depression?

The FDA has recently required drug companies to provide warnings on the labels of all antidepressants because of evidence that these drugs may induce

Which of the following phenomena is supportive of the neurotrophic theory of major depression?

The most significant problem associated with the use of lithium in the treatment of affective disorders is

Psychopharmacology in Perspective

Drug Classification and Behavioral Assessment

Basic Principles of Pharmacology

Excitability and Chemical Signaling in Nerve Cells

Synaptic Transmission, Drugs, and Chemical Neuroanatomy

Tolerance, Sensitization, Dependence, and Addiction

Psychomotor Stimulants and Antiparkinsonian Drugs

Antipsychotic Drugs and Neurochemical Hypotheses of Schizophrenia

Sedative-Hypnotics, Anxiolytics, and Anticonvulsants

Drug Treatment of Cognitive Dysfunction

Naturally Occurring and Synthetic Opiates and Their Antagonists

Dissociative Anesthetics

Filters