Question 1

The earliest catecholamine hypothesis of affective disorders suggested that depression results from

Accepted Answer

A) an excessive amount of norepinephrine activity 
B) an excessive amount of dopamine activity 
C) a deficiency of norepinephrine and/or dopamine in the brain 
D) none of these 
A) an excessive amount of norepinephrine activity 
B) an excessive amount of dopamine activity 
C) a deficiency of norepinephrine and/or dopamine in the brain 
D) none of these

Question 2

One side effect of tricyclic antidepressants which is least likely to occur is

Accepted Answer

A) psychological dependence 
B) death resulting from overdose 
C) disorientation and mental sedation 
D) cardiovascular dysfunction 
A) psychological dependence 
B) death resulting from overdose 
C) disorientation and mental sedation 
D) cardiovascular dysfunction

Question 3

The primary benefits of the newer antidepressants developed in the past 15 years over the older tricyclic and monoamine oxidase inhibitor classes of antidepressants is in the area of

Accepted Answer

A) increased percentage of patients experiencing relief from depression 
B) reduced lethal toxicity and side effects 
C) both of these 
D) none of the above 
A) increased percentage of patients experiencing relief from depression 
B) reduced lethal toxicity and side effects 
C) both of these 
D) none of the above

Question 4

Tricyclic antidepressants typically

Accepted Answer

A) reduce catecholamine reuptake 
B) enhance catecholamine synthesis 
C) enhance catecholamine reuptake 
D) enhance catecholamine release 
A) reduce catecholamine reuptake 
B) enhance catecholamine synthesis 
C) enhance catecholamine reuptake 
D) enhance catecholamine release

Question 5

Venlafaxine (Effexor) and duloxetine (Cymbalta) are two of the newest antidepressants to be approved for use in the treatment of depression.These drugs were developed because of their ability to

Accepted Answer

A) more selectively inhibit monoamine oxidase 
B) more selectively enhance monoamine reuptake 
C) selectively inhibit the reuptake of both serotonin and norepinephrine 
D) selectively inhibit the reuptake of dopamine 
A) more selectively inhibit monoamine oxidase 
B) more selectively enhance monoamine reuptake 
C) selectively inhibit the reuptake of both serotonin and norepinephrine 
D) selectively inhibit the reuptake of dopamine

Question 6

Lithium's primary mechanism of action with respect to its beneficial effects

Accepted Answer

A) is unknown 
B) involves enhancing catecholamine release from axons 
C) involves activation of catecholamine receptors 
D) involves synthesis of endogenous opioid peptides 
A) is unknown 
B) involves enhancing catecholamine release from axons 
C) involves activation of catecholamine receptors 
D) involves synthesis of endogenous opioid peptides

Question 7

The so-called "serotonin syndrome" is most likely going to occur when SSRIs are combined with

Accepted Answer

A) tricyclic antidepressants 
B) St.John's wort 
C) monoamine oxidase inhibitors 
D) all of these 
A) tricyclic antidepressants 
B) St.John's wort 
C) monoamine oxidase inhibitors 
D) all of these

Question 8

Which of the following pharmacodynamic properties do drugs effective in the treatment of depression have?

Accepted Answer

A) selective inhibition of serotonin reuptake 
B) noradrenergic reuptake inhibition 
C) inhibition of monoamine oxidase 
D) all of these 
A) selective inhibition of serotonin reuptake 
B) noradrenergic reuptake inhibition 
C) inhibition of monoamine oxidase 
D) all of these

Question 9

The newest FDA-approved class of antidepressant drugs that don't typically induce sedation or anticholinergic side effects

Accepted Answer

A) are selective serotonin reuptake inhibitors 
B) have been shown to increase the symptoms of obsessive-compulsive disorders 
C) have a higher abuse potential than earlier antidepressants 
D) all of the above 
A) are selective serotonin reuptake inhibitors 
B) have been shown to increase the symptoms of obsessive-compulsive disorders 
C) have a higher abuse potential than earlier antidepressants 
D) all of the above

Question 10

At the present time in the U.S., the most widely prescribed group of antidepressants consist of the

Accepted Answer

A) tricyclics 
B) monoamine oxidase inhibitors 
C) lithium and its derivatives 
D) selective serotonin reuptake inhibitors 
A) tricyclics 
B) monoamine oxidase inhibitors 
C) lithium and its derivatives 
D) selective serotonin reuptake inhibitors

Question 11

With respect to tolerance and dependence, most of the evidence suggests that with chronic use of tricyclic antidepressants

Accepted Answer

A) tolerance to their antidepressant properties does not develop 
B) abrupt drug cessation may precipitate malaise, chills, muscle aches, and hypercholinergic-type effects 
C) abrupt cessation of their use does not induce depression 
D) all of the above 
A) tolerance to their antidepressant properties does not develop 
B) abrupt drug cessation may precipitate malaise, chills, muscle aches, and hypercholinergic-type effects 
C) abrupt cessation of their use does not induce depression 
D) all of the above

Question 12

Which of the following is an appropriate statement regarding clinical treatment of depression with monoamine oxidase inhibitors (MAOIs)?

Accepted Answer

A) MAOIs should generally be tried before tricyclics are used 
B) MAOIs should generally be tried before selective serotonin reuptake inhibitors are used 
C) MAOIs should generally be tried before employing lithium in the treatment of bipolar depression 
D) none of the above are true 
A) MAOIs should generally be tried before tricyclics are used 
B) MAOIs should generally be tried before selective serotonin reuptake inhibitors are used 
C) MAOIs should generally be tried before employing lithium in the treatment of bipolar depression 
D) none of the above are true

Question 13

In the 1950s, the first effective drugs that specifically reduced the symptoms of depression were developed or discovered.One of these belonged to the class of antidepressants categorized as

Accepted Answer

A) monoamine oxidase inhibitors 
B) tricyclics 
C) amphetamines 
D) both a and b 
A) monoamine oxidase inhibitors 
B) tricyclics 
C) amphetamines 
D) both a and b

Question 14

The potency of effective antidepressants differ considerably in terms of their

Accepted Answer

A) ability to block norepinephrine uptake 
B) ability to block serotonin uptake 
C) anticholinergic properties 
D) all of these 
A) ability to block norepinephrine uptake 
B) ability to block serotonin uptake 
C) anticholinergic properties 
D) all of these

Question 15

Which of the following is NOT one of the three major classifications of antidepressants?

Accepted Answer

A) monoamine oxidase inhibitors 
B) dopamine receptor blockers 
C) selective serotonin reuptake inhibitors 
D) tricyclics 
A) monoamine oxidase inhibitors 
B) dopamine receptor blockers 
C) selective serotonin reuptake inhibitors 
D) tricyclics

Question 16

An alternative to lithium in the treatment of manic-depression is/are

Accepted Answer

A) antipsychotics 
B) carbamazepine (Tegretol) 
C) antiseizure drugs 
D) all of these 
A) antipsychotics 
B) carbamazepine (Tegretol) 
C) antiseizure drugs 
D) all of these

Question 17

Although effective in the treatment of depression, these drugs are also one of the most effective treatments for the symptoms of obsessive-compulsive disorder.

Accepted Answer

A) psychostimulants 
B) dopamine receptor antagonists like Haldol 
C) selective serotonin reuptake inhibitors 
D) all of these 
A) psychostimulants 
B) dopamine receptor antagonists like Haldol 
C) selective serotonin reuptake inhibitors 
D) all of these

Question 18

How are the primary mechanisms of most antidepressant drugs potentially related to the "neurotrophic" theory of mood disorders?

Accepted Answer

Since serotonin and norepinephrine play

Question 19

Briefly describe the "neurotrophic" theory of mood disorders.

Accepted Answer

The general premise of this model is tha

Question 20

Monoamine oxidase inhibitors are likely to increase intraneuronal levels of

Accepted Answer

A) norepinephrine 
B) dopamine 
C) serotonin 
D) all of these 
A) norepinephrine 
B) dopamine 
C) serotonin 
D) all of these

The earliest catecholamine hypothesis of affective disorders suggested that depression results from

One side effect of tricyclic antidepressants which is least likely to occur is

The primary benefits of the newer antidepressants developed in the past 15 years over the older tricyclic and monoamine oxidase inhibitor classes of antidepressants is in the area of

Tricyclic antidepressants typically

Venlafaxine (Effexor) and duloxetine (Cymbalta) are two of the newest antidepressants to be approved for use in the treatment of depression.These drugs were developed because of their ability to

Lithium's primary mechanism of action with respect to its beneficial effects

The so-called "serotonin syndrome" is most likely going to occur when SSRIs are combined with

Which of the following pharmacodynamic properties do drugs effective in the treatment of depression have?

The newest FDA-approved class of antidepressant drugs that don't typically induce sedation or anticholinergic side effects

At the present time in the U.S., the most widely prescribed group of antidepressants consist of the

With respect to tolerance and dependence, most of the evidence suggests that with chronic use of tricyclic antidepressants

Which of the following is an appropriate statement regarding clinical treatment of depression with monoamine oxidase inhibitors (MAOIs)?

In the 1950s, the first effective drugs that specifically reduced the symptoms of depression were developed or discovered.One of these belonged to the class of antidepressants categorized as

The potency of effective antidepressants differ considerably in terms of their

Which of the following is NOT one of the three major classifications of antidepressants?

An alternative to lithium in the treatment of manic-depression is/are

Although effective in the treatment of depression, these drugs are also one of the most effective treatments for the symptoms of obsessive-compulsive disorder.

How are the primary mechanisms of most antidepressant drugs potentially related to the "neurotrophic" theory of mood disorders?

Briefly describe the "neurotrophic" theory of mood disorders.

Monoamine oxidase inhibitors are likely to increase intraneuronal levels of

Psychopharmacology in Perspective

Drug Classification and Behavioral Assessment

Basic Principles of Pharmacology

Excitability and Chemical Signaling in Nerve Cells

Synaptic Transmission, Drugs, and Chemical Neuroanatomy

Tolerance, Sensitization, Dependence, and Addiction

Psychomotor Stimulants and Antiparkinsonian Drugs

Antipsychotic Drugs and Neurochemical Hypotheses of Schizophrenia

Sedative-Hypnotics, Anxiolytics, and Anticonvulsants

Drug Treatment of Cognitive Dysfunction

Naturally Occurring and Synthetic Opiates and Their Antagonists

Dissociative Anesthetics

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Exam 9: Antidepressants and Mood Stabilizers

The earliest catecholamine hypothesis of affective disorders suggested that depression results from

One side effect of tricyclic antidepressants which is least likely to occur is

The primary benefits of the newer antidepressants developed in the past 15 years over the older tricyclic and monoamine oxidase inhibitor classes of antidepressants is in the area of

Tricyclic antidepressants typically

Venlafaxine (Effexor) and duloxetine (Cymbalta) are two of the newest antidepressants to be approved for use in the treatment of depression.These drugs were developed because of their ability to

Lithium's primary mechanism of action with respect to its beneficial effects

The so-called "serotonin syndrome" is most likely going to occur when SSRIs are combined with

Which of the following pharmacodynamic properties do drugs effective in the treatment of depression have?

The newest FDA-approved class of antidepressant drugs that don't typically induce sedation or anticholinergic side effects

At the present time in the U.S., the most widely prescribed group of antidepressants consist of the

With respect to tolerance and dependence, most of the evidence suggests that with chronic use of tricyclic antidepressants

Which of the following is an appropriate statement regarding clinical treatment of depression with monoamine oxidase inhibitors (MAOIs)?

In the 1950s, the first effective drugs that specifically reduced the symptoms of depression were developed or discovered.One of these belonged to the class of antidepressants categorized as

The potency of effective antidepressants differ considerably in terms of their

Which of the following is NOT one of the three major classifications of antidepressants?

An alternative to lithium in the treatment of manic-depression is/are

Although effective in the treatment of depression, these drugs are also one of the most effective treatments for the symptoms of obsessive-compulsive disorder.

How are the primary mechanisms of most antidepressant drugs potentially related to the "neurotrophic" theory of mood disorders?

Briefly describe the "neurotrophic" theory of mood disorders.

Monoamine oxidase inhibitors are likely to increase intraneuronal levels of

Psychopharmacology in Perspective

Drug Classification and Behavioral Assessment

Basic Principles of Pharmacology

Excitability and Chemical Signaling in Nerve Cells

Synaptic Transmission, Drugs, and Chemical Neuroanatomy

Tolerance, Sensitization, Dependence, and Addiction

Psychomotor Stimulants and Antiparkinsonian Drugs

Antipsychotic Drugs and Neurochemical Hypotheses of Schizophrenia

Sedative-Hypnotics, Anxiolytics, and Anticonvulsants

Drug Treatment of Cognitive Dysfunction

Naturally Occurring and Synthetic Opiates and Their Antagonists

Dissociative Anesthetics

Filters