Question 1

The human genome project's first draft took approximately ________ years.

Accepted Answer

A)  5 
B)  13 
C)  3 
D)  50 
A)  5 
B)  13 
C)  3 
D)  50

Question 2

Gene knockouts in mice can be useful because

Accepted Answer

A)  they can be used to develop models of human disease. 
B)  they identify DNA binding proteins. 
C)  they limit mRNA production both from the knockout as well as the normal allele in diploids. 
D)  only genes that are actively transcribed in the embryo are susceptible to being knocked out. 
A)  they can be used to develop models of human disease. 
B)  they identify DNA binding proteins. 
C)  they limit mRNA production both from the knockout as well as the normal allele in diploids. 
D)  only genes that are actively transcribed in the embryo are susceptible to being knocked out.

Question 3

Select all advantages of RNA-Seq as compared to DNA microarrays.

Accepted Answer

A)  Better detection of transcripts present at low levels 
B)  Identifies boundaries of introns and exons to determine splice variants 
C)  More accurately quantifies the amount of each transcript 
D)  Does not require isolation of RNA from the cell 
E)  Does not require cDNA synthesis 
A)  Better detection of transcripts present at low levels 
B)  Identifies boundaries of introns and exons to determine splice variants 
C)  More accurately quantifies the amount of each transcript 
D)  Does not require isolation of RNA from the cell 
E)  Does not require cDNA synthesis

Question 4

The term gene knockout refers to a gene alteration that inhibits the genes that are adjacent to it.

Accepted Answer

A) True 
 B)False

Question 5

If all members of a population have the identical DNA segment,it is said to be ________.

Accepted Answer

A)  monomorphic 
B)  polymorphic 
C)  trimorphic 
D)  neomorphic 
A)  monomorphic 
B)  polymorphic 
C)  trimorphic 
D)  neomorphic

Question 6

Shotgun sequencing is precise enough to achieve a complete genomic sequence without the need for other mapping methods.

Accepted Answer

A) True 
 B)False

Question 7

Which of the following procedures best determines the relative order,but not precise location,of a series of genes on a chromosome?

Accepted Answer

A)  physical mapping 
B)  cytogenetic mapping 
C)  linkage mapping 
D)  shotgun sequencing 
A)  physical mapping 
B)  cytogenetic mapping 
C)  linkage mapping 
D)  shotgun sequencing

Question 8

In shotgun sequencing,how is a complete sequence of a genome reconstructed?

Accepted Answer

A)  The entire genome is directly sequenced chromosome by chromosome. 
B)  The genome is fragmented and sequences of each fragment are arranged so that overlapping regions are identified. 
C)  The sequences of a large number of individuals is obtained and "averaged" to obtain the complete sequence. 
D)  The position of each marker and gene are first mapped relative to regions for which the genomic sequence is not known. 
A)  The entire genome is directly sequenced chromosome by chromosome. 
B)  The genome is fragmented and sequences of each fragment are arranged so that overlapping regions are identified. 
C)  The sequences of a large number of individuals is obtained and "averaged" to obtain the complete sequence. 
D)  The position of each marker and gene are first mapped relative to regions for which the genomic sequence is not known.

Question 9

The experimental process of determining the relative location of genes or other segments of DNA along individual chromosomes is called

Accepted Answer

A)  mapping. 
B)  metagenomics. 
C)  DNA sequencing. 
D)  proteomics. 
A)  mapping. 
B)  metagenomics. 
C)  DNA sequencing. 
D)  proteomics.

Question 10

What is in situ hybridization used for?

Accepted Answer

A)  cytogenetic mapping 
B)  physical mapping 
C)  linkage mapping 
D)  sequencing 
A)  cytogenetic mapping 
B)  physical mapping 
C)  linkage mapping 
D)  sequencing

Question 11

In the screening of a DNA microarray,detection of a fluorescent signal from one of the genes indicates which of the following?

Accepted Answer

A)  The labeled cDNA hybridized to that particular gene. 
B)  The labeled cDNA did not hybridize to that particular gene. 
C)  The experiment was not conducted correctly. 
D)  None of these choices are correct. 
A)  The labeled cDNA hybridized to that particular gene. 
B)  The labeled cDNA did not hybridize to that particular gene. 
C)  The experiment was not conducted correctly. 
D)  None of these choices are correct.

Question 12

The method of sequencing genomic fragments cloned straight from the genome is

Accepted Answer

A)  cytogenetic mapping. 
B)  shotgun sequencing. 
C)  southern blotting. 
D)  dideoxy blotting. 
A)  cytogenetic mapping. 
B)  shotgun sequencing. 
C)  southern blotting. 
D)  dideoxy blotting.

Question 13

A small glass chip that contains thousands of microscopic pieces of DNA is called a DNA microarray.

Accepted Answer

A) True 
 B)False

Question 14

Which researcher(s)are using a metagenomic approach?

Accepted Answer

A)  A medical researcher studies the DNA of mixed bacterial populations from the intestines of patients with different diseases. 
B)  A plant biologist sequences the genomes of broccoli, cauliflower, and other Brassica species to determine which genes are responsible for their different features. 
C)  A developmental geneticist clones the mutated gene from a Drosophila strain with disrupted wing development. 
D)  An environmental researcher sequences DNA from collections of microbes living in polluted coastal waters, which cannot be cultured in the lab. 
E)  A pharmaceutical developer screens through DNA found in soil samples for novel antibiotics. 
A)  A medical researcher studies the DNA of mixed bacterial populations from the intestines of patients with different diseases. 
B)  A plant biologist sequences the genomes of broccoli, cauliflower, and other Brassica species to determine which genes are responsible for their different features. 
C)  A developmental geneticist clones the mutated gene from a Drosophila strain with disrupted wing development. 
D)  An environmental researcher sequences DNA from collections of microbes living in polluted coastal waters, which cannot be cultured in the lab. 
E)  A pharmaceutical developer screens through DNA found in soil samples for novel antibiotics.

Question 15

A complex collection of genes from a specific environmental sample is a ________.

Accepted Answer

A)  microgenome 
B)  metagenome 
C)  linkage map 
D)  microarray 
A)  microgenome 
B)  metagenome 
C)  linkage map 
D)  microarray

The human genome project's first draft took approximately ________ years.

Gene knockouts in mice can be useful because

Select all advantages of RNA-Seq as compared to DNA microarrays.

The term gene knockout refers to a gene alteration that inhibits the genes that are adjacent to it.

If all members of a population have the identical DNA segment,it is said to be ________.

Shotgun sequencing is precise enough to achieve a complete genomic sequence without the need for other mapping methods.

Which of the following procedures best determines the relative order,but not precise location,of a series of genes on a chromosome?

In shotgun sequencing,how is a complete sequence of a genome reconstructed?

The experimental process of determining the relative location of genes or other segments of DNA along individual chromosomes is called

What is in situ hybridization used for?

In the screening of a DNA microarray,detection of a fluorescent signal from one of the genes indicates which of the following?

The method of sequencing genomic fragments cloned straight from the genome is

A small glass chip that contains thousands of microscopic pieces of DNA is called a DNA microarray.

Which researcher(s)are using a metagenomic approach?

A complex collection of genes from a specific environmental sample is a ________.

Overview of Genetics

Reproduction and Chromosome Transmission

Mendelian Inheritance

Sex Determination and Sex Chromosomes

Extensions of Mendelian Inheritance

Extranuclear Inheritance, Imprinting, and Maternal Effect

Genetic Linkage and Mapping in Eukaryotes

Variation in Chromosome Structure and Number

Genetics in Bacteria

Genetics of Viruses

Molecular Structure of DNA and RNA

Molecular Structure of Chromosomes and Transposition

Dna Replication and Recombination

Gene Transcription and RNA Modification

Translation of MRNA

Gene Regulation in Bacteria

Gene Regulation in Eukaryotes

Non-Coding Rnas

Gene Mutation and DNA Repair

Molecular Technologies

Medical Genetics and Cancer

Population Genetics

Quantitative Genetics

Filters

Exam 21: Genomics

The human genome project's first draft took approximately ________ years.

Gene knockouts in mice can be useful because

Select all advantages of RNA-Seq as compared to DNA microarrays.

The term gene knockout refers to a gene alteration that inhibits the genes that are adjacent to it.

If all members of a population have the identical DNA segment,it is said to be ________.

Shotgun sequencing is precise enough to achieve a complete genomic sequence without the need for other mapping methods.

Which of the following procedures best determines the relative order,but not precise location,of a series of genes on a chromosome?

In shotgun sequencing,how is a complete sequence of a genome reconstructed?

The experimental process of determining the relative location of genes or other segments of DNA along individual chromosomes is called

What is in situ hybridization used for?

In the screening of a DNA microarray,detection of a fluorescent signal from one of the genes indicates which of the following?

The method of sequencing genomic fragments cloned straight from the genome is

A small glass chip that contains thousands of microscopic pieces of DNA is called a DNA microarray.

Which researcher(s)are using a metagenomic approach?

A complex collection of genes from a specific environmental sample is a ________.

Overview of Genetics

Reproduction and Chromosome Transmission

Mendelian Inheritance

Sex Determination and Sex Chromosomes

Extensions of Mendelian Inheritance

Extranuclear Inheritance, Imprinting, and Maternal Effect

Genetic Linkage and Mapping in Eukaryotes

Variation in Chromosome Structure and Number

Genetics in Bacteria

Genetics of Viruses

Molecular Structure of DNA and RNA

Molecular Structure of Chromosomes and Transposition

Dna Replication and Recombination

Gene Transcription and RNA Modification

Translation of MRNA

Gene Regulation in Bacteria

Gene Regulation in Eukaryotes

Non-Coding Rnas

Gene Mutation and DNA Repair

Molecular Technologies

Medical Genetics and Cancer

Population Genetics

Quantitative Genetics

Filters