Question 1

Most trinucleotide repeat expansion repeats involve expansion of which of the following?

Accepted Answer

A)  GAA 
B)  CAG 
C)  ATG 
D)  any codon containing three of the same bases 
A)  GAA 
B)  CAG 
C)  ATG 
D)  any codon containing three of the same bases

Question 2

A mutation in a promoter region that causes the promoter sequence to more closely resemble the consensus sequence is called an up promoter mutation and decreases transcription.

Accepted Answer

A) True 
 B)False

Question 3

Mutagens change the structure of DNA,which may lead to mutations.

Accepted Answer

A) True 
 B)False

Question 4

An individual that is a genetic mosaic would be the result of a germ cell mutation.

Accepted Answer

A) True 
 B)False

Question 5

Silent mutations are possible due to the degenerate nature of the genetic code.

Accepted Answer

A) True 
 B)False

Question 6

Anticipation is associated with which of the following?

Accepted Answer

A)  nonsense mutations 
B)  up-promoter mutations 
C)  intergenic suppressors 
D)  TRNE mutations 
A)  nonsense mutations 
B)  up-promoter mutations 
C)  intergenic suppressors 
D)  TRNE mutations

Question 7

If an organism has a mutation in a gene that causes it to be sterile,a mutation in a second gene that restores fertility is a suppressor mutation.

Accepted Answer

A) True 
 B)False

Question 8

The results of the replica plating experiments by the Lederbergs supported which of the following theories?

Accepted Answer

A)  random mutation theory 
B)  physiological adaptation theory 
C)  both theories 
D)  neither theory 
A)  random mutation theory 
B)  physiological adaptation theory 
C)  both theories 
D)  neither theory

Question 9

The conversion of cytosine to uracil in DNA is an example of ________.

Accepted Answer

A)  depurination 
B)  tautomeric shifts 
C)  deamination 
D)  None of the answers are correct. 
A)  depurination 
B)  tautomeric shifts 
C)  deamination 
D)  None of the answers are correct.

Question 10

Which process is used to replicate DNA that contains distortions due to unrepaired DNA damage?

Accepted Answer

A)  Translesion synthesis 
B)  Homologous recombination repair 
C)  Nonhomologous end joining 
D)  Nucleotide excision repair 
A)  Translesion synthesis 
B)  Homologous recombination repair 
C)  Nonhomologous end joining 
D)  Nucleotide excision repair

Question 11

What process repairs damage from UV radiation?

Accepted Answer

A)  homologous recombination repair 
B)  direct repair 
C)  base excision repair 
D)  mismatch repair 
E)  nucleotide excision repair 
A)  homologous recombination repair 
B)  direct repair 
C)  base excision repair 
D)  mismatch repair 
E)  nucleotide excision repair

Question 12

Which of the following is not an example of a spontaneous mutation?

Accepted Answer

A)  DNA replication errors 
B)  tautomeric shifts 
C)  aberrant recombination 
D)  UV light 
E)  transposable elements 
A)  DNA replication errors 
B)  tautomeric shifts 
C)  aberrant recombination 
D)  UV light 
E)  transposable elements

Question 13

TNRE repeats frequently result in the addition of extra histidine amino acids to the protein.

Accepted Answer

A) True 
 B)False

Question 14

In the following sequence of DNA,the italicized base has been mutated.What type of mutation is this?
5' - G A T C T C C G A A T T - 3' original strand
5' - G A T C T C C C A A T T - 3' mutated strand

Accepted Answer

A)  transition 
B)  transversion 
C)  neither 
A)  transition 
B)  transversion 
C)  neither

Question 15

A heritable change in the genetic material is called a mutation.

Accepted Answer

A) True 
 B)False

Question 16

The most common genotype in a population is called the mutant genotype.

Accepted Answer

A) True 
 B)False

Question 17

Which of the following is correct regarding the rate of mutation?

Accepted Answer

A)  Rates of mutation per cell generation typically range from 10−⁵ to 10−⁹. 
B)  Mutation rates are consistent across species. 
C)  Mutation rates are not influenced by environmental conditions. 
D)  Mutation rates are constant. 
A)  Rates of mutation per cell generation typically range from 10−⁵ to 10−⁹. 
B)  Mutation rates are consistent across species. 
C)  Mutation rates are not influenced by environmental conditions. 
D)  Mutation rates are constant.

Question 18

In the nucleotide excision repair system,which of the following proteins is responsible for recognizing a thymine dimer to be repaired?

Accepted Answer

A)  UvrA/UvrB 
B)  UvrC 
C)  UvrD 
D)  None of the answers are correct. 
A)  UvrA/UvrB 
B)  UvrC 
C)  UvrD 
D)  None of the answers are correct.

Question 19

Translocations and inversions may cause which of the following?

Accepted Answer

A)  TRNE 
B)  anticipation 
C)  position effect 
D)  genome mutations 
A)  TRNE 
B)  anticipation 
C)  position effect 
D)  genome mutations

Question 20

Which of the following are examples of spontaneous mutations?

Accepted Answer

A)  depurination 
B)  deamination 
C)  tautomeric shifts 
D)  nitrogenous base oxidation 
A)  depurination 
B)  deamination 
C)  tautomeric shifts 
D)  nitrogenous base oxidation

Exam 19: Gene Mutation and DNA Repair

Most trinucleotide repeat expansion repeats involve expansion of which of the following?

A mutation in a promoter region that causes the promoter sequence to more closely resemble the consensus sequence is called an up promoter mutation and decreases transcription.

Mutagens change the structure of DNA,which may lead to mutations.

An individual that is a genetic mosaic would be the result of a germ cell mutation.

Silent mutations are possible due to the degenerate nature of the genetic code.

Anticipation is associated with which of the following?

If an organism has a mutation in a gene that causes it to be sterile,a mutation in a second gene that restores fertility is a suppressor mutation.

The results of the replica plating experiments by the Lederbergs supported which of the following theories?

The conversion of cytosine to uracil in DNA is an example of ________.

Which process is used to replicate DNA that contains distortions due to unrepaired DNA damage?

What process repairs damage from UV radiation?

Which of the following is not an example of a spontaneous mutation?

TNRE repeats frequently result in the addition of extra histidine amino acids to the protein.

In the following sequence of DNA,the italicized base has been mutated.What type of mutation is this? 5' - G A T C T C C G A A T T - 3' original strand 5' - G A T C T C C C A A T T - 3' mutated strand

A heritable change in the genetic material is called a mutation.

The most common genotype in a population is called the mutant genotype.

Which of the following is correct regarding the rate of mutation?

In the nucleotide excision repair system,which of the following proteins is responsible for recognizing a thymine dimer to be repaired?

Translocations and inversions may cause which of the following?

Which of the following are examples of spontaneous mutations?

Overview of Genetics

Reproduction and Chromosome Transmission

Mendelian Inheritance

Sex Determination and Sex Chromosomes

Extensions of Mendelian Inheritance

Extranuclear Inheritance, Imprinting, and Maternal Effect

Genetic Linkage and Mapping in Eukaryotes

Variation in Chromosome Structure and Number

Genetics in Bacteria

Genetics of Viruses

Molecular Structure of DNA and RNA

Molecular Structure of Chromosomes and Transposition

Dna Replication and Recombination

Gene Transcription and RNA Modification

Translation of MRNA

Gene Regulation in Bacteria

Gene Regulation in Eukaryotes

Non-Coding Rnas

Molecular Technologies

Genomics

Medical Genetics and Cancer

Population Genetics

Quantitative Genetics

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