Question 1

In antigen binding,MHC protein binds to the T cell epitope,whereas the TCR binds the MHC motif.

Accepted Answer

A) True 
 B)False

Question 2

Why is the secondary immune response stronger in regard to antibodies?

Accepted Answer

Somatic hypermutation creates B cells be

Question 3

The ________ and ________ domains of the class II MHC protein interact to form a peptide-binding site.

Accepted Answer

A)  B / T 
B)  light / heavy 
C)  C / V 
D)  α1 / β1 
A)  B / T 
B)  light / heavy 
C)  C / V 
D)  α1 / β1

Question 4

Immunoglobins associate with the adapter molecules Igα and Igβ.

Accepted Answer

A) True 
 B)False

Question 5

In clonal selection,cells that have not interacted with antigen do not proliferate.

Accepted Answer

A) True 
 B)False

Question 6

Clonal anergy is a state of

Accepted Answer

A)  antibody production. 
B)  high energy. 
C)  unresponsiveness. 
D)  high energy and antibody production. 
A)  antibody production. 
B)  high energy. 
C)  unresponsiveness. 
D)  high energy and antibody production.

Question 7

Affinity maturation is one of the factors responsible for a stronger secondary immune response.

Accepted Answer

A) True 
 B)False

Question 8

Given that T cell receptors (TCRs)are randomly generated during the maturation process,how are new T cells selected that can recognize self-antigens and other immune cells appropriately?

Accepted Answer

Positive selection selects for T cells t

Question 9

Predict the consequence for an individual of a deleterious genetic mutation in the gene for TLR-4.

Accepted Answer

A mutation that changes TLR-4 would hamp

Question 10

Interaction of a PAMP with a TLR triggers transmembrane signal transduction and subsequent

Accepted Answer

A)  clonal expansion. 
B)  antibody production. 
C)  complement protein activation. 
D)  phagocytosis and inflammation. 
A)  clonal expansion. 
B)  antibody production. 
C)  complement protein activation. 
D)  phagocytosis and inflammation.

Question 11

The antigen-binding site of an antibody accommodates a small portion of the antigen called a(n)

Accepted Answer

A)  lipopolysaccharide. 
B)  epitope. 
C)  peptide motif. 
D)  pathogen associated molecular pattern (PAMP). 
A)  lipopolysaccharide. 
B)  epitope. 
C)  peptide motif. 
D)  pathogen associated molecular pattern (PAMP).

Question 12

Chemokines produced by activated macrophages include

Accepted Answer

A)  CXL8. 
B)  CCL2. 
C)  MCP-1. 
D)  CXL8, CCL2, and MCP-1. 
A)  CXL8. 
B)  CCL2. 
C)  MCP-1. 
D)  CXL8, CCL2, and MCP-1.

Question 13

TCRs are found exclusively on T cells.

Accepted Answer

A) True 
 B)False

Question 14

Some immature B cells are reactive to self-antigens but do not become activated even when exposed to high concentrations of self-antigens.

Accepted Answer

A) True 
 B)False

Question 15

All TLR can react with only one specific PAMP.

Accepted Answer

A) True 
 B)False

Question 16

Adapter molecules associate covalently with their respective antigen receptors in the membrane.

Accepted Answer

A) True 
 B)False

Question 17

________ ensures that each B cell produces only one immunoglobulin.

Accepted Answer

A)  Self-activation 
B)  Allelic exclusion 
C)  MHC interaction 
D)  Clonal deletion 
A)  Self-activation 
B)  Allelic exclusion 
C)  MHC interaction 
D)  Clonal deletion

Question 18

Immunoglobulins and TCRs associate with adaptor molecules that have

Accepted Answer

A)  a C domain. 
B)  immune-based tyrosine-activation motifs (ITAMs). 
C)  pathogen recognition receptors. 
D)  toll-like receptors. 
A)  a C domain. 
B)  immune-based tyrosine-activation motifs (ITAMs). 
C)  pathogen recognition receptors. 
D)  toll-like receptors.

Question 19

Mannose on mammalian cells is inaccessible to mannose-binding lectin.

Accepted Answer

A) True 
 B)False

Question 20

The two-stage thymic selection process for selecting self-tolerant,antigen-reactive T cells results in

Accepted Answer

A)  allelic exclusion. 
B)  clonal deletion. 
C)  complementarity-determining regions. 
D)  somatic hypermutation. 
A)  allelic exclusion. 
B)  clonal deletion. 
C)  complementarity-determining regions. 
D)  somatic hypermutation.

Exam 26: Molecular Immunology

In antigen binding,MHC protein binds to the T cell epitope,whereas the TCR binds the MHC motif.

Why is the secondary immune response stronger in regard to antibodies?

The ________ and ________ domains of the class II MHC protein interact to form a peptide-binding site.

Immunoglobins associate with the adapter molecules Igα and Igβ.

In clonal selection,cells that have not interacted with antigen do not proliferate.

Clonal anergy is a state of

Affinity maturation is one of the factors responsible for a stronger secondary immune response.

Given that T cell receptors (TCRs)are randomly generated during the maturation process,how are new T cells selected that can recognize self-antigens and other immune cells appropriately?

Predict the consequence for an individual of a deleterious genetic mutation in the gene for TLR-4.

Interaction of a PAMP with a TLR triggers transmembrane signal transduction and subsequent

The antigen-binding site of an antibody accommodates a small portion of the antigen called a(n)

Chemokines produced by activated macrophages include

TCRs are found exclusively on T cells.

Some immature B cells are reactive to self-antigens but do not become activated even when exposed to high concentrations of self-antigens.

All TLR can react with only one specific PAMP.

Adapter molecules associate covalently with their respective antigen receptors in the membrane.

________ ensures that each B cell produces only one immunoglobulin.

Immunoglobulins and TCRs associate with adaptor molecules that have

Mannose on mammalian cells is inaccessible to mannose-binding lectin.

The two-stage thymic selection process for selecting self-tolerant,antigen-reactive T cells results in

Microorganisms and Microbiology

Microbial Cell Structure and Function

Microbial Metabolism

Molecular Biology

Microbial Growth and Control

Microbial Genomics

Metabolic Regulation

Viruses and Virology

Viral Genomes and Diversity

Genetics of Bacteria and Archaea

Genetic Engineering and Biotechnology

Microbial Evolution and Systematics

Metabolic Diversity of Microorganisms

Functional Diversity of Bacteria

Diversity of Bacteria

Diversity of Archaea

Diversity of Eukaryotic Microorganisms

Methods in Microbial Ecology

Microbial Ecosystems

Nutrient Cycles

Microbiology of the Built Environment

Microbial Symbioses

Microbial Interactions With Humans

Immunity and Host Defense

Immune Mechanisms

Diagnostic Microbiology

Epidemiology

Person-To-Person Bacterial and Viral Diseases

Vectorborne and Soilborne Bacterial and Viral Diseases

Water and Food As Vehicles of Bacterial Diseases

Eukaryotic Pathogens: Fungal and Parasitic Diseases

Filters

The and domains of the class II MHC protein interact to form a peptide-binding site.