Question 1

An epitope is ________ amino acids long.

Accepted Answer

A)  3-5 
B)  10-15 
C)  50-60 
D)  700 
A)  3-5 
B)  10-15 
C)  50-60 
D)  700

Question 2

More than ________ % of all T cell precursors that enter the thymus do NOT survive the selection process.

Accepted Answer

A)  15 
B)  25 
C)  45 
D)  95 
A)  15 
B)  25 
C)  45 
D)  95

Question 3

Each of the V domains in immunoglobulins has ________ complementarity-determining regions.

Accepted Answer

A)  one 
B)  two 
C)  three 
D)  four 
A)  one 
B)  two 
C)  three 
D)  four

Question 4

In B cell selection and tolerance,if no signal is generated from ________ cells,the B cells remain unresponsive.

Accepted Answer

A)  TC 
B)  TH 
C)  B₇ 
D)  CD₂₈ 
A)  TC 
B)  TH 
C)  B₇ 
D)  CD₂₈

Question 5

The embedded peptides in MHC proteins are normally derived from breakdown products of cell metabolism.

Accepted Answer

A) True 
 B)False

Question 6

Each immunoglobulin or TCR interacts with a single antigen,but MHC proteins can interact with more than one antigen.

Accepted Answer

A) True 
 B)False

Question 7

The human leukocyte antigen spans about 4Mbp on human chromosome 6.

Accepted Answer

A) True 
 B)False

Question 8

Somatic hypermutation occurs only in the ________ regions of rearranged heavy and light chains.

Accepted Answer

A)  D 
B)  HV 
C)  J 
D)  V 
A)  D 
B)  HV 
C)  J 
D)  V

Question 9

When two allelic variants are expressed equally,they are said to be

Accepted Answer

A)  exclusive. 
B)  uncommitted. 
C)  repressed. 
D)  codominant. 
A)  exclusive. 
B)  uncommitted. 
C)  repressed. 
D)  codominant.

Question 10

Class I MHC proteins have grooves with open ends.

Accepted Answer

A) True 
 B)False

Question 11

Signal transduction pathways initiate activation of transcription after specific

Accepted Answer

A)  TH cell death. 
B)  ligand-receptor binding on the cell surface. 
C)  cytokines diffuse across the cytoplasmic membrane. 
D)  antigen-antibody binding. 
A)  TH cell death. 
B)  ligand-receptor binding on the cell surface. 
C)  cytokines diffuse across the cytoplasmic membrane. 
D)  antigen-antibody binding.

Question 12

The main bonds present in the C domain of antigen-binding proteins are

Accepted Answer

A)  hydrogen bonds. 
B)  intrachain disulfide bonds. 
C)  ionic bonds. 
D)  van der Waals forces. 
A)  hydrogen bonds. 
B)  intrachain disulfide bonds. 
C)  ionic bonds. 
D)  van der Waals forces.

Question 13

Which of the following is involved in B cell selection and tolerance?

Accepted Answer

A)  clonal anergy 
B)  clonal deletion 
C)  clonal anergy and deletion 
D)  allelic exclusion 
A)  clonal anergy 
B)  clonal deletion 
C)  clonal anergy and deletion 
D)  allelic exclusion

Question 14

Assuming that each heavy and light chain has an equal chance to be expressed in each cell,approximately how many possible antibodies can be expressed?

Accepted Answer

A)  192 
B)  1,920 
C)  19,200 
D)  1,920,000 
A)  192 
B)  1,920 
C)  19,200 
D)  1,920,000

Question 15

Which of the following biomolecules interact with toll-like receptors (TLRs)?

Accepted Answer

A)  bacterial LPS 
B)  immunoglobulins 
C)  major histocompatibility complex proteins 
D)  none of these 
A)  bacterial LPS 
B)  immunoglobulins 
C)  major histocompatibility complex proteins 
D)  none of these

Question 16

Interaction of a pathogen-associated molecular pattern (PAMP)with a pattern recognition receptor (PRR)results in

Accepted Answer

A)  formation of transmembrane pores that cause cell lysis. 
B)  transmembrane signal transduction that initiates transcription of genes involved in phagocytosis, inflammation, and pathogen killing. 
C)  molecular activation of the adaptive immune system. 
D)  a superantigen reaction that can cause septic shock. 
A)  formation of transmembrane pores that cause cell lysis. 
B)  transmembrane signal transduction that initiates transcription of genes involved in phagocytosis, inflammation, and pathogen killing. 
C)  molecular activation of the adaptive immune system. 
D)  a superantigen reaction that can cause septic shock.

Question 17

The mechanism by which antigen-reactive cells respond to foreign antigens while ignoring self-antigens is called clonal

Accepted Answer

A)  selection. 
B)  deletion. 
C)  anergy. 
D)  expansion. 
A)  selection. 
B)  deletion. 
C)  anergy. 
D)  expansion.

Question 18

The complete second signal for B cell activation requires which of the following interactions?

Accepted Answer

A)  CD40-CK40L interaction 
B)  cytokine-cytokine receptor interaction 
C)  TH-B cell interaction 
D)  All of these are necessary. 
A)  CD40-CK40L interaction 
B)  cytokine-cytokine receptor interaction 
C)  TH-B cell interaction 
D)  All of these are necessary.

Question 19

Which of the following is a likely target for a toll-like receptor (TLR)?

Accepted Answer

A)  tumor necrosis factor 
B)  interleukin IV 
C)  flagellin 
D)  insulin 
A)  tumor necrosis factor 
B)  interleukin IV 
C)  flagellin 
D)  insulin

Question 20

B cells react with antigens through TCR antigen receptors.

Accepted Answer

A) True 
 B)False

Exam 26: Molecular Immunology

An epitope is ________ amino acids long.

More than ________ % of all T cell precursors that enter the thymus do NOT survive the selection process.

Each of the V domains in immunoglobulins has ________ complementarity-determining regions.

In B cell selection and tolerance,if no signal is generated from ________ cells,the B cells remain unresponsive.

The embedded peptides in MHC proteins are normally derived from breakdown products of cell metabolism.

Each immunoglobulin or TCR interacts with a single antigen,but MHC proteins can interact with more than one antigen.

The human leukocyte antigen spans about 4Mbp on human chromosome 6.

Somatic hypermutation occurs only in the ________ regions of rearranged heavy and light chains.

When two allelic variants are expressed equally,they are said to be

Class I MHC proteins have grooves with open ends.

Signal transduction pathways initiate activation of transcription after specific

The main bonds present in the C domain of antigen-binding proteins are

Which of the following is involved in B cell selection and tolerance?

Assuming that each heavy and light chain has an equal chance to be expressed in each cell,approximately how many possible antibodies can be expressed?

Which of the following biomolecules interact with toll-like receptors (TLRs)?

Interaction of a pathogen-associated molecular pattern (PAMP)with a pattern recognition receptor (PRR)results in

The mechanism by which antigen-reactive cells respond to foreign antigens while ignoring self-antigens is called clonal

The complete second signal for B cell activation requires which of the following interactions?

Which of the following is a likely target for a toll-like receptor (TLR)?

B cells react with antigens through TCR antigen receptors.

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