Question 1

Select the most common antibody specificity associated with hemolytic disease of the fetus and newborn.

Accepted Answer

A) Anti-A,B 
B) Anti-C 
C) Anti-D 
D) Anti-K 
A) Anti-A,B 
B) Anti-C 
C) Anti-D 
D) Anti-K

Question 2

To prevent graft-versus-host disease,red blood cells prepared for intrauterine transfusions should be:

Accepted Answer

A) frozen and deglycerolized. 
B) saline washed. 
C) ABO and D-compatible with the mother. 
D) irradiated. 
A) frozen and deglycerolized. 
B) saline washed. 
C) ABO and D-compatible with the mother. 
D) irradiated.

Question 3

Why is reverse grouping omitted in the neonatal period for ABO testing?

Accepted Answer

A) The maternal antibody is identical to that of the newborn. 
B) Newborns do not produce their own antibody until about 4 months. 
C) The newborn's antibody is the same as the paternal antibody. 
D) None of the above is correct. 
A) The maternal antibody is identical to that of the newborn. 
B) Newborns do not produce their own antibody until about 4 months. 
C) The newborn's antibody is the same as the paternal antibody. 
D) None of the above is correct.

Question 4

Amniotic fluid analysis showed a marked increase into zone III of the Liley graph.Lecithin-sphingomyelin ratios indicated that the fetal lungs were not mature.Select the most appropriate decision regarding medical intervention.

Accepted Answer

A) No immediate need for intervention 
B) An intrauterine transfusion 
C) Delivery by cesarean section 
D) None of the above 
A) No immediate need for intervention 
B) An intrauterine transfusion 
C) Delivery by cesarean section 
D) None of the above

Question 5

During a first-trimester prenatal examination,it was determined that a pregnant woman was group A,D-negative with an anti-D titer of 8.What is the most likely course of action?

Accepted Answer

A) The anti-D is probably from prenatal Rh immune globulin and should be given another dose at birth. 
B) Repeat the titer in 4 weeks to determine if significant if a rise in titer is detected. 
C) The pregnancy is considered high risk,and the mother should be followed up immediately with amniocentesis or percutaneous umbilical cord testing. 
D) None of the above are correct. 
A) The anti-D is probably from prenatal Rh immune globulin and should be given another dose at birth. 
B) Repeat the titer in 4 weeks to determine if significant if a rise in titer is detected. 
C) The pregnancy is considered high risk,and the mother should be followed up immediately with amniocentesis or percutaneous umbilical cord testing. 
D) None of the above are correct.

Question 6

A .3% fetomaternal bleed was determined by a Kleihauer Betke stain of postpartum blood.What is the estimated volume of the fetomaternal bleed expressed as whole blood?

Accepted Answer

A) 10 mL 
B) 15 mL 
C) 20 mL 
D) 25 mL 
A) 10 mL 
B) 15 mL 
C) 20 mL 
D) 25 mL

Question 7

In which type of hemolytic disease of the fetus and newborn is the first-born affected?

Accepted Answer

A) ABO 
B) D 
C) E 
D) M 
A) ABO 
B) D 
C) E 
D) M

Question 8

Which elution method is ideal in the investigation of ABO hemolytic disease of the fetus and newborn?

Accepted Answer

A) Glycine-acid 
B) Freeze-thaw 
C) Xylene 
D) Chloroform 
A) Glycine-acid 
B) Freeze-thaw 
C) Xylene 
D) Chloroform

Question 9

The Kleihauer Betke test was performed using a 1-hour postdelivery maternal blood sample.Results: 10 fetal cells/1000 cells counted It is the policy to add 1 vial of Rh immune globulin to the calculated dose when the estimated volume of the hemorrhage exceeds 20 mL of whole blood.Calculate the number of vials of Rh immune globulin that would be indicated under these circumstances.

Accepted Answer

A) 2 
B) 3 
C) 4 
D) 5 
A) 2 
B) 3 
C) 4 
D) 5

Question 10

Which of the following best describes the principle of the Kleihauer-Betke test?

Accepted Answer

A) Fetal hemoglobin is resistant to acid elution and remains in the cell to stain pink,whereas adult cells appear as ghost cells. 
B) Adult hemoglobin is resistant to acid elution and remains in the cell to stain pink,whereas fetal cells appear as ghost cells. 
C) D-positive cells from the fetus form rosettes around the IgG-coated mother's cells. 
D) Indicator cells form rosettes around the fetal D-positive cells. 
A) Fetal hemoglobin is resistant to acid elution and remains in the cell to stain pink,whereas adult cells appear as ghost cells. 
B) Adult hemoglobin is resistant to acid elution and remains in the cell to stain pink,whereas fetal cells appear as ghost cells. 
C) D-positive cells from the fetus form rosettes around the IgG-coated mother's cells. 
D) Indicator cells form rosettes around the fetal D-positive cells.

Select the most common antibody specificity associated with hemolytic disease of the fetus and newborn.

To prevent graft-versus-host disease,red blood cells prepared for intrauterine transfusions should be:

Why is reverse grouping omitted in the neonatal period for ABO testing?

Amniotic fluid analysis showed a marked increase into zone III of the Liley graph.Lecithin-sphingomyelin ratios indicated that the fetal lungs were not mature.Select the most appropriate decision regarding medical intervention.

During a first-trimester prenatal examination,it was determined that a pregnant woman was group A,D-negative with an anti-D titer of 8.What is the most likely course of action?

A .3% fetomaternal bleed was determined by a Kleihauer Betke stain of postpartum blood.What is the estimated volume of the fetomaternal bleed expressed as whole blood?

In which type of hemolytic disease of the fetus and newborn is the first-born affected?

Which elution method is ideal in the investigation of ABO hemolytic disease of the fetus and newborn?

Which of the following best describes the principle of the Kleihauer-Betke test?

Immunology: Basic Principles and Applications in the Blood Bank

Blood Banking Reagents: Overview and Applications

Genetic Principles in Blood Banking

Abo and H Blood Group Systems and Secretor Status

Rh Blood Group System

Other Blood Group Systems

Antibody Detection and Identification

Compatibility Testing

Blood Bank Automation for Transfusion Services

Adverse Complications of Transfusions

Donor Selection and Phlebotomy

Testing of Donor Blood

Blood Component Preparation and Therapy

Transfusion Therapy in Selected Patients

Quality Assurance and Regulation of the Blood Industry and Safety Issues in the Blood Bank

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Exam 11: Hemolytic Disease of the Fetus and Newborn

Select the most common antibody specificity associated with hemolytic disease of the fetus and newborn.

To prevent graft-versus-host disease,red blood cells prepared for intrauterine transfusions should be:

Why is reverse grouping omitted in the neonatal period for ABO testing?

Amniotic fluid analysis showed a marked increase into zone III of the Liley graph.Lecithin-sphingomyelin ratios indicated that the fetal lungs were not mature.Select the most appropriate decision regarding medical intervention.

During a first-trimester prenatal examination,it was determined that a pregnant woman was group A,D-negative with an anti-D titer of 8.What is the most likely course of action?

A .3% fetomaternal bleed was determined by a Kleihauer Betke stain of postpartum blood.What is the estimated volume of the fetomaternal bleed expressed as whole blood?

In which type of hemolytic disease of the fetus and newborn is the first-born affected?

Which elution method is ideal in the investigation of ABO hemolytic disease of the fetus and newborn?

Which of the following best describes the principle of the Kleihauer-Betke test?

Immunology: Basic Principles and Applications in the Blood Bank

Blood Banking Reagents: Overview and Applications

Genetic Principles in Blood Banking

Abo and H Blood Group Systems and Secretor Status

Rh Blood Group System

Other Blood Group Systems

Antibody Detection and Identification

Compatibility Testing

Blood Bank Automation for Transfusion Services

Adverse Complications of Transfusions

Donor Selection and Phlebotomy

Testing of Donor Blood

Blood Component Preparation and Therapy

Transfusion Therapy in Selected Patients

Quality Assurance and Regulation of the Blood Industry and Safety Issues in the Blood Bank

Filters