Exam 1: Immunology: Basic Principles and Applications in the Blood Bank

It was observed that an antibody identified in the transfusion service appeared to be reacting stronger following the second exposure to an antigen from a transfusion.The most likely explanation of this is:

Extravascular destruction of blood cells occurs in the:

Select the term that is associated with the B-cell response to antigens.

Select the immunoglobulin class from the list below that best fits the characteristic described.Each class can be used more than once. -Associated with intravascular cell destruction

The major histocompatibility complex is located on chromosome 6 and is important in all the following immune functions except:

Select the immunoglobulin class from the list below that best fits the characteristic described.Each class can be used more than once. -Associated with allergic reactions and mast cell activation

Select the term from the list below that best fits the definitions. -Imparts flexibility to the immunoglobulin molecule

Which of the following will cause an antigen to elicit a greater immune response?

What portion of the antibody molecule binds to receptors on macrophages and assists in the removal of antibody bound to red cells?

Select the term from the list below that best fits the definitions. -Variable region of an immunoglobulin

Which class of HLA antigens would be typed when matching patient and donors for platelet transfusion?

Select the portion of the antibody molecule that imparts the antibody's unique class function.

In the complement cascade,lysis of the target cell is mediated by which of the following components?

Select the immunoglobulin class from the list below that best fits the characteristic described.Each class can be used more than once. -Efficient in activation of the complement cascade

Which of the following is responsible for the activation of the classic pathway of complement?

A patient's record indicated that he had a history of an antibody to HPA-1a.What is the significance of this antibody if this patient requires a platelet transfusion?

In order to enhance the reaction of an antibody in vitro,it may be necessary to adjust which of the following?

Select the term from the list below that best fits the definitions. -Part of the antigen that the immunoglobulin binds to

Select the substance that regulates the activity of other cells by binding to specific receptors.

What immunoglobulin class is capable of crossing the placenta?