Question 1

A patient phenotypes as D+C+E-c-e+.Predict the most likely genotype.

Accepted Answer

A)  R₁r 
B)  R₁R₁ 
C)  R₁r' 
D)  R₁R₀ 
A)  R₁r 
B)  R₁R₁ 
C)  R₁r' 
D)  R₁R₀ B

Question 2

The frequency of the D-negative phenotype in the population is:

Accepted Answer

A)  15%. 
B)  85%. 
C)  50%. 
D)  35%. 
A)  15%. 
B)  85%. 
C)  50%. 
D)  35%. A

Question 3

All of the following can cause the D antigen expression to be weaker except:

Accepted Answer

A)  inheriting the G gene. 
B)  inheriting the C antigen in trans to the D antigen. 
C)  an RHD gene that is genetically weaker. 
D)  partial D expression. 
A)  inheriting the G gene. 
B)  inheriting the C antigen in trans to the D antigen. 
C)  an RHD gene that is genetically weaker. 
D)  partial D expression. A

Question 4

MATCHING
Match the following phenotypes with the most probable genotype in the Weiner nomenclature.
-DCe

Accepted Answer

A) R₁r 
B) R₁R₁ 
C) R₂R₂ 
D) rr 
A) R₁r 
B) R₁R₁ 
C) R₂R₂ 
D) rr

Question 5

Current theory regarding the genetics of the Rh system suggests that:

Accepted Answer

A)  each Rh system antigen is coded by its own gene locus. 
B)  Rh system antigens are coded by two closely linked genes. 
C)  one gene locus with multiple alleles codes for the protein antigens. 
D)  the Rh system genes are a haplotype that codes for three sets of alleles. 
A)  each Rh system antigen is coded by its own gene locus. 
B)  Rh system antigens are coded by two closely linked genes. 
C)  one gene locus with multiple alleles codes for the protein antigens. 
D)  the Rh system genes are a haplotype that codes for three sets of alleles.

Question 6

Which of the following phenotypes will react with anti-f?

Accepted Answer

A)  rr 
B)  R₁R₁ 
C)  R₂R₂ 
D)  R₁R₂ 
A)  rr 
B)  R₁R₁ 
C)  R₂R₂ 
D)  R₁R₂

Question 7

Anti-D reagent and the D control were tested with patient's red cells.Both tests were 2+ agglutination reactions.What is the interpretation of the results?

Accepted Answer

A)  D-positive 
B)  D-negative 
C)  Unable to interpret without further testing 
D)  D-positive if the sample is from a patient 
A)  D-positive 
B)  D-negative 
C)  Unable to interpret without further testing 
D)  D-positive if the sample is from a patient

Question 8

If a D-positive person appears to have anti-D in their serum,what is the most likely explanation?

Accepted Answer

A)  D-deletion phenotype 
B)  Compound antigen 
C)  Partial D antigen 
D)  Transposition effect 
A)  D-deletion phenotype 
B)  Compound antigen 
C)  Partial D antigen 
D)  Transposition effect

Question 9

MATCHING
Match the following phenotypes with the most probable genotype in the Weiner nomenclature.
-DcE

Accepted Answer

A) R₁r 
B) R₁R₁ 
C) R₂R₂ 
D) rr 
A) R₁r 
B) R₁R₁ 
C) R₂R₂ 
D) rr

Question 10

An anti-E was identified in a patient who recently received a transfusion.What other Rh system antibody should be investigated?

Accepted Answer

A)  Anti-G 
B)  Anti-f 
C)  Anti-D 
D)  Anti-c 
A)  Anti-G 
B)  Anti-f 
C)  Anti-D 
D)  Anti-c

Question 11

An individual's red cells gave the following reactions with antisera:
$\begin{array}{|l|l|l|l|l|l|}
\hline \text { Anti-D } & \text { Anti-C } & \text { Anti-E } & \text { Anti-c } & \text { Anti-e } & \text { Rh control } \
\hline 4+ & 3+ & 0 & 3+ & 3+ & 0
\end{array}$

The most probable genotype is:

Accepted Answer

A)  R₁R₂. 
B)  R2r. 
C)  R₀r. 
D)  R₁r. 
A)  R₁R₂. 
B)  R2r. 
C)  R₀r. 
D)  R₁r.

Question 12

The weak D test detects:

Accepted Answer

A)  the Du antigen. 
B)  the missing D mosaic. 
C)  a weak D antibody. 
D)  a weak D antigen. 
A)  the Du antigen. 
B)  the missing D mosaic. 
C)  a weak D antibody. 
D)  a weak D antigen.

Question 13

The LW antigen expression is typically stronger on _____________ red cells.

Accepted Answer

A)  D-positive 
B)  D-negative 
C)  Rh null 
D)  D-variant 
A)  D-positive 
B)  D-negative 
C)  Rh null 
D)  D-variant

Question 14

The inheritance of the Rh antigens are:

Accepted Answer

A)  X-linked recessive. 
B)  X-linked dominant. 
C)  autosomal recessive. 
D)  codominant. 
A)  X-linked recessive. 
B)  X-linked dominant. 
C)  autosomal recessive. 
D)  codominant.

Question 15

Which of the following is associated with the Rhnᵤll phenotype?

Accepted Answer

A)  Membrane abnormalities 
B)  Immunized Rhnull individuals may produce anti-Rh29 
C)  Mutation of the RhAG regulator gene 
D)  All of the above 
A)  Membrane abnormalities 
B)  Immunized Rhnull individuals may produce anti-Rh29 
C)  Mutation of the RhAG regulator gene 
D)  All of the above

Question 16

Match the Fisher-Race notation with the correct Weiner notation for the following:
-r'

Accepted Answer

A) Ce 
B) CE 
C) DCE 
D) Dce 
A) Ce 
B) CE 
C) DCE 
D) Dce

Question 17

The numeric Rh4 nomenclature refers to which antigen in the Rosenfield notation?

Accepted Answer

A)  C 
B)  c 
C)  e 
D)  E 
A)  C 
B)  c 
C)  e 
D)  E

Question 18

How would you label a donor who tested negative with anti-D reagent upon immediate-spin and positive in antihuman globulin test?

Accepted Answer

A)  D-positive 
B)  D-negative 
C)  Cannot label; more testing needed 
A)  D-positive 
B)  D-negative 
C)  Cannot label; more testing needed

Question 19

How is it genetically possible for a child to phenotype as D-negative?

Accepted Answer

A)  Both parents are heterozygous D-positive. 
B)  Both parents are homozygous D-positive. 
C)  Mom is homozygous D-positive, and Dad is heterozygous D-positive. 
D)  The sibling is D-positive. 
A)  Both parents are heterozygous D-positive. 
B)  Both parents are homozygous D-positive. 
C)  Mom is homozygous D-positive, and Dad is heterozygous D-positive. 
D)  The sibling is D-positive.

Question 20

MATCHING
Match the following phenotypes with the most probable genotype in the Weiner nomenclature.
-DCce

Accepted Answer

A) R₁r 
B) R₁R₁ 
C) R₂R₂ 
D) rr 
A) R₁r 
B) R₁R₁ 
C) R₂R₂ 
D) rr

A patient phenotypes as D+C+E-c-e+.Predict the most likely genotype.

The frequency of the D-negative phenotype in the population is:

All of the following can cause the D antigen expression to be weaker except:

MATCHING Match the following phenotypes with the most probable genotype in the Weiner nomenclature. -DCe

Current theory regarding the genetics of the Rh system suggests that:

Which of the following phenotypes will react with anti-f?

Anti-D reagent and the D control were tested with patient's red cells.Both tests were 2+ agglutination reactions.What is the interpretation of the results?

If a D-positive person appears to have anti-D in their serum,what is the most likely explanation?

MATCHING Match the following phenotypes with the most probable genotype in the Weiner nomenclature. -DcE

An anti-E was identified in a patient who recently received a transfusion.What other Rh system antibody should be investigated?

An individual's red cells gave the following reactions with antisera: Anti-D Anti-C Anti-E Anti-c Anti-e Rh control 4+ 3+ 0 3+ 3+ 0 The most probable genotype is:

The weak D test detects:

The LW antigen expression is typically stronger on _____________ red cells.

The inheritance of the Rh antigens are:

Which of the following is associated with the Rhnᵤll phenotype?

Match the Fisher-Race notation with the correct Weiner notation for the following: -r'

The numeric Rh4 nomenclature refers to which antigen in the Rosenfield notation?

How would you label a donor who tested negative with anti-D reagent upon immediate-spin and positive in antihuman globulin test?

How is it genetically possible for a child to phenotype as D-negative?

MATCHING Match the following phenotypes with the most probable genotype in the Weiner nomenclature. -DCce

Quality Assurance and Regulation of the Blood Industry and Safety Issues in the Blood Bank

Immunology: Basic Principles and Applications in the Blood Bank

Blood Banking Reagents: Overview and Applications

Genetic Principles in Blood Banking

ABO and H Blood Group Systems and Secretor Status

Other Red Cell Blood Group Systems, Human Leukocyte Antigens, and Platelet Antigens

Antibody Detection and Identification

Compatibility Testing

Blood Bank Automation for Transfusion Services

Adverse Complications of Transfusions

Hemolytic Disease of the Fetus and Newborn

Donor Selection and Phlebotomy

Testing of Donor Blood

Blood Component Preparation and Therapy

Transfusion Therapy in Selected Patients

Filters

Exam 6: Rh Blood Group System

A patient phenotypes as D+C+E-c-e+.Predict the most likely genotype.

The frequency of the D-negative phenotype in the population is:

All of the following can cause the D antigen expression to be weaker except:

MATCHING Match the following phenotypes with the most probable genotype in the Weiner nomenclature. -DCe

Current theory regarding the genetics of the Rh system suggests that:

Which of the following phenotypes will react with anti-f?

Anti-D reagent and the D control were tested with patient's red cells.Both tests were 2+ agglutination reactions.What is the interpretation of the results?

If a D-positive person appears to have anti-D in their serum,what is the most likely explanation?

MATCHING Match the following phenotypes with the most probable genotype in the Weiner nomenclature. -DcE

An anti-E was identified in a patient who recently received a transfusion.What other Rh system antibody should be investigated?

An individual's red cells gave the following reactions with antisera: Anti-D Anti-C Anti-E Anti-c Anti-e Rh control 4+ 3+ 0 3+ 3+ 0 The most probable genotype is:

The weak D test detects:

The LW antigen expression is typically stronger on _____________ red cells.

The inheritance of the Rh antigens are:

Which of the following is associated with the Rhnᵤll phenotype?

Match the Fisher-Race notation with the correct Weiner notation for the following: -r'

The numeric Rh4 nomenclature refers to which antigen in the Rosenfield notation?

How would you label a donor who tested negative with anti-D reagent upon immediate-spin and positive in antihuman globulin test?

How is it genetically possible for a child to phenotype as D-negative?

MATCHING Match the following phenotypes with the most probable genotype in the Weiner nomenclature. -DCce

Quality Assurance and Regulation of the Blood Industry and Safety Issues in the Blood Bank

Immunology: Basic Principles and Applications in the Blood Bank

Blood Banking Reagents: Overview and Applications

Genetic Principles in Blood Banking

ABO and H Blood Group Systems and Secretor Status

Other Red Cell Blood Group Systems, Human Leukocyte Antigens, and Platelet Antigens

Antibody Detection and Identification

Compatibility Testing

Blood Bank Automation for Transfusion Services

Adverse Complications of Transfusions

Hemolytic Disease of the Fetus and Newborn

Donor Selection and Phlebotomy

Testing of Donor Blood

Blood Component Preparation and Therapy

Transfusion Therapy in Selected Patients

Filters