Question 1

Traditional treatment of rheumatoid arthritis (RA) includes the ______________ class of drugs.

Accepted Answer

A) nonsteroidal antiinflammatory 
B) corticosteroid 
C) disease-modifying antirheumatic 
D) All of the above. 
A) nonsteroidal antiinflammatory 
B) corticosteroid 
C) disease-modifying antirheumatic 
D) All of the above. D

Question 2

Which of the following immunoglobulins or molecular components is used in rheumatoid factor (RF) rapid slide assays?

Accepted Answer

A) Fc portion of IgM 
B) Fc portion of IgG 
C) IgM 
D) IgG 
A) Fc portion of IgM 
B) Fc portion of IgG 
C) IgM 
D) IgG B

Question 3

Immunologic features of rheumatoid arthritis include antinuclear antibodies (ANAs).

Accepted Answer

A) True 
 B)False  True

Question 4

A biologic false-positive rheumatoid factor (RF) assay can be manifested by patients with

Accepted Answer

A) systemic lupus erythematosus (SL
E) . 
B) hepatitis. 
C) syphilis. 
D) All of the above. 
A) systemic lupus erythematosus (SL
E) . 
B) hepatitis. 
C) syphilis. 
D) All of the above.

Question 5

Being rheumatoid factor (RF)-positive correlates with the severity of the disease (in general).

Accepted Answer

A) True 
 B)False

Question 6

The RA agglutination test is based on the reaction between patient antibodies in the serum, known as the rheumatoid factor, and an antigen derived from

Accepted Answer

A) human gamma globulin (IgM). 
B) rabbit gamma globulin (IgM). 
C) human gamma globulin (IgG). 
D) rabbit gamma globulin (IgG). 
A) human gamma globulin (IgM). 
B) rabbit gamma globulin (IgM). 
C) human gamma globulin (IgG). 
D) rabbit gamma globulin (IgG).

Question 7

Prognostic markers that may help identify patients with more severe RA who are still in the early stages of the disease include persistently high numbers of swollen joints.

Accepted Answer

A) True 
 B)False

Question 8

Being rheumatoid factor (RF)-positive correlates with other organ system involvement (e.g., vasculitis, Felty's syndrome, Sjögren's syndrome).

Accepted Answer

A) True 
 B)False

Question 9

Immunologic features of rheumatoid arthritis include immune complexes.

Accepted Answer

A) True 
 B)False

Question 10

The immunoglobulin classes most often associated with rheumatoid factors (RFs) are

Accepted Answer

A) IgM and IgG. 
B) IgG and IgA. 
C) IgM and IgA. 
D) IgA and IgD. 
A) IgM and IgG. 
B) IgG and IgA. 
C) IgM and IgA. 
D) IgA and IgD.

Question 11

Prognostic markers that may help identify patients with more severe RA who are still in the early stages of the disease include low serum levels of acute-phase reactants of immunoglobulin M (IgM) rheumatoid factor.

Accepted Answer

A) True 
 B)False

Question 12

Immunologic features of rheumatoid arthritis include anti-cyclic citrullinated peptide (anti-CCP).

Accepted Answer

A) True 
 B)False

Question 13

Being rheumatoid factor (RF)-positive correlates with the absence of nodules.

Accepted Answer

A) True 
 B)False

Question 14

Rheumatoid arthritis (RA) is characterized by

Accepted Answer

A) joint pain and tenderness. 
B) the presence of rheumatoid factor in the blood. 
C) association with HLA-DR genes. 
D) All of the above. 
A) joint pain and tenderness. 
B) the presence of rheumatoid factor in the blood. 
C) association with HLA-DR genes. 
D) All of the above.

Question 15

Pathogenic mechanisms hypothesized for rheumatoid arthritis include

Accepted Answer

A) an infective agent or other stimulus binds to receptors on dendritic cells (DCs). 
B) activated T lymphocytes proliferate and migrate into the joint. 
C) complement activation. 
D) Both A and B. 
A) an infective agent or other stimulus binds to receptors on dendritic cells (DCs). 
B) activated T lymphocytes proliferate and migrate into the joint. 
C) complement activation. 
D) Both A and B.

Question 16

The female-to-male ratio in patients with rheumatoid arthritis (RA) is

Accepted Answer

A) 0.5:1. 
B) 1:1. 
C) 2.5:1. 
D) 2:3. 
A) 0.5:1. 
B) 1:1. 
C) 2.5:1. 
D) 2:3.

Question 17

The laboratory serum agglutination assay for rheumatoid factor (RF)

Accepted Answer

A) detects IgG rheumatoid factors. 
B) detects IgM rheumatoid factors. 
C) does not generate many false-positive results. 
D) is sensitive to changes in RF titer. 
A) detects IgG rheumatoid factors. 
B) detects IgM rheumatoid factors. 
C) does not generate many false-positive results. 
D) is sensitive to changes in RF titer.

Question 18

Prognostic markers that may help identify patients with more severe RA who are still in the early stages of the disease include the presence of certain HLA class I alleles.

Accepted Answer

A) True 
 B)False

Question 19

In RA, stimulated macrophages and fibroblasts release cytokines. One that is particularly important is

Accepted Answer

A) TNF-$\alpha$. 
B) complement. 
C) IL-30. 
D) IL-15. 
A) TNF-$\alpha$. 
B) complement. 
C) IL-30. 
D) IL-15.

Exam 29: Rheumatoid Arthritis

Traditional treatment of rheumatoid arthritis (RA) includes the ______________ class of drugs.

Which of the following immunoglobulins or molecular components is used in rheumatoid factor (RF) rapid slide assays?

Immunologic features of rheumatoid arthritis include antinuclear antibodies (ANAs).

A biologic false-positive rheumatoid factor (RF) assay can be manifested by patients with

Being rheumatoid factor (RF)-positive correlates with the severity of the disease (in general).

The RA agglutination test is based on the reaction between patient antibodies in the serum, known as the rheumatoid factor, and an antigen derived from

Prognostic markers that may help identify patients with more severe RA who are still in the early stages of the disease include persistently high numbers of swollen joints.

Being rheumatoid factor (RF)-positive correlates with other organ system involvement (e.g., vasculitis, Felty's syndrome, Sjögren's syndrome).

Immunologic features of rheumatoid arthritis include immune complexes.

The immunoglobulin classes most often associated with rheumatoid factors (RFs) are

Prognostic markers that may help identify patients with more severe RA who are still in the early stages of the disease include low serum levels of acute-phase reactants of immunoglobulin M (IgM) rheumatoid factor.

Immunologic features of rheumatoid arthritis include anti-cyclic citrullinated peptide (anti-CCP).

Being rheumatoid factor (RF)-positive correlates with the absence of nodules.

Rheumatoid arthritis (RA) is characterized by

Pathogenic mechanisms hypothesized for rheumatoid arthritis include

The female-to-male ratio in patients with rheumatoid arthritis (RA) is

The laboratory serum agglutination assay for rheumatoid factor (RF)

Prognostic markers that may help identify patients with more severe RA who are still in the early stages of the disease include the presence of certain HLA class I alleles.

In RA, stimulated macrophages and fibroblasts release cytokines. One that is particularly important is

An Overview of Immunology

Antigens and Antibodies

Cells and Cellular Activities of the Immune System: Granulocytes and Mononuclear Cells

Cells and Cellular Activities of the Immune System: Lymphocytes and Plasma Cells

Soluble Mediators of the Immune System

Safety in the Immunology-Serology Laboratory

Quality Assurance and Quality Control

Basic Serologic Laboratory Techniques

Rapid Testing

Precipitation and Particle Agglutination Methods

Electrophoresis Techniques

Labeling Techniques in Immunoassay

Flow Cytometry

Molecular Laboratory Techniques

Infectious Diseases: Traditional and Alternate Diagnostic Techniques

Streptococcal Infections

Syphilis

Vector-Borne Diseases

Toxoplasmosis

Cytomegalovirus

Infectious Mononucleosis

Viral Hepatitis

Rubella and Rubeola Infections

Primary and Acquired Immune Deficiency Syndromes

Hypersensitivity Reactions

Immunoproliferative Disorders

Tolerance, Autoimmunity, and Autoimmune Diseases

Systemic Lupus Erythematosus

Transplantation: Hla, Solid Organ, and Hematopoietic Stem Cells

Tumor Immunology and Up-To-Date Applications of Next-Generation Sequencing

Primer on Vaccines

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