Question 1

Immunocompetent individuals maintain EBV as a(n)

Accepted Answer

A) active infection. 
B) chronic latent infection. 
C) asymptomatic carrier. 
D) symptomatic carrier. 
A) active infection. 
B) chronic latent infection. 
C) asymptomatic carrier. 
D) symptomatic carrier. B

Question 2

A blood transfusion from an immune donor to a nonimmune recipient may produce

Accepted Answer

A) no effect. 
B) a primary infection. 
C) a secondary infection. 
D) a reactivated infection. 
A) no effect. 
B) a primary infection. 
C) a secondary infection. 
D) a reactivated infection. B

Question 3

Match each procedure to the appropriate description.
-Davidsohn differential test

Accepted Answer

A) Distinguishes between heterophile antibodies; uses beef erythrocytes, guinea pig kidney cells, and sheep erythrocytes. 
B) Detects heterophile antibodies and uses horse erythrocytes. 
C) Detects heterophile antibodies and uses sheep erythrocytes. 
A) Distinguishes between heterophile antibodies; uses beef erythrocytes, guinea pig kidney cells, and sheep erythrocytes. 
B) Detects heterophile antibodies and uses horse erythrocytes. 
C) Detects heterophile antibodies and uses sheep erythrocytes. A

Question 4

Match each procedure to the appropriate description.
-Paul-Bunnell screening test

Accepted Answer

A) Distinguishes between heterophile antibodies; uses beef erythrocytes, guinea pig kidney cells, and sheep erythrocytes. 
B) Detects heterophile antibodies and uses horse erythrocytes. 
C) Detects heterophile antibodies and uses sheep erythrocytes. 
A) Distinguishes between heterophile antibodies; uses beef erythrocytes, guinea pig kidney cells, and sheep erythrocytes. 
B) Detects heterophile antibodies and uses horse erythrocytes. 
C) Detects heterophile antibodies and uses sheep erythrocytes.

Question 5

Immunoglobulin M (IgM) heterophile antibody is characterized by no absorption by beef erythrocytes.

Accepted Answer

A) True 
 B)False

Question 6

The use of horse erythrocytes in rapid slide tests for infectious mononucleosis increases the

Accepted Answer

A) readability. 
B) sensitivity. 
C) specificity. 
D) All of the above. 
A) readability. 
B) sensitivity. 
C) specificity. 
D) All of the above.

Question 7

Epstein-Barr virus (EBV) is

Accepted Answer

A) a DNA herpesvirus. 
B) harbored by B lymphocytes in latent infections. 
C) the most ubiquitous virus known to humans. 
D) All of the above. 
A) a DNA herpesvirus. 
B) harbored by B lymphocytes in latent infections. 
C) the most ubiquitous virus known to humans. 
D) All of the above.

Question 8

Viral capsid antigen (VCA) is produced by

Accepted Answer

A) phagocytic neutrophils. 
B) infected T lymphocytes. 
C) infected B lymphocytes. 
D) Both B and C. 
A) phagocytic neutrophils. 
B) infected T lymphocytes. 
C) infected B lymphocytes. 
D) Both B and C.

Question 9

Anti-VCA immunoglobulin G (IgG) is usually detectable within

Accepted Answer

A) 24 hours. 
B) 72 hours. 
C) 3 to 5 days. 
D) 4 to 7 days. 
A) 24 hours. 
B) 72 hours. 
C) 3 to 5 days. 
D) 4 to 7 days.

Question 10

All the following statements about Epstein-Barr virus (EBV) are true except that it

Accepted Answer

A) usually causes an acute, benign condition. 
B) usually causes a self-limiting, lymphoproliferative condition. 
C) is the cause of Burkitt's lymphoma. 
D) is not an agent in the development of nasopharyngeal carcinoma. 
A) usually causes an acute, benign condition. 
B) usually causes a self-limiting, lymphoproliferative condition. 
C) is the cause of Burkitt's lymphoma. 
D) is not an agent in the development of nasopharyngeal carcinoma.

Question 11

Immunoglobulin M (IgM) heterophile antibody is characterized by reaction with horse, ox, and sheep erythrocytes.

Accepted Answer

A) True 
 B)False

Question 12

Match each procedure to the appropriate description.
-MonoSlide agglutination test

Accepted Answer

A) Distinguishes between heterophile antibodies; uses beef erythrocytes, guinea pig kidney cells, and sheep erythrocytes. 
B) Detects heterophile antibodies and uses horse erythrocytes. 
C) Detects heterophile antibodies and uses sheep erythrocytes. 
A) Distinguishes between heterophile antibodies; uses beef erythrocytes, guinea pig kidney cells, and sheep erythrocytes. 
B) Detects heterophile antibodies and uses horse erythrocytes. 
C) Detects heterophile antibodies and uses sheep erythrocytes.

Question 13

In rapid MonoSlide testing, a false-positive result can be caused by

Accepted Answer

A) observing agglutination after the observation time. 
B) misinterpreting agglutination. 
C) residual heterophile antibody present after clinical symptoms have subsided. 
D) All of the above. 
A) observing agglutination after the observation time. 
B) misinterpreting agglutination. 
C) residual heterophile antibody present after clinical symptoms have subsided. 
D) All of the above.

Question 14

In infectious mononucleosis, EBV

Accepted Answer

A) infects B lymphocytes. 
B) produces lymphocytes in peripheral blood with T cell characteristics. 
C) induces a cytotoxic response against the EBV-infected circulating B lymphocytes. 
D) All of the above. 
A) infects B lymphocytes. 
B) produces lymphocytes in peripheral blood with T cell characteristics. 
C) induces a cytotoxic response against the EBV-infected circulating B lymphocytes. 
D) All of the above.

Question 15

In the adult population, ________ of individuals with acute infectious mononucleosis do not produce heterophile antibodies.

Accepted Answer

A) 5% to 10% 
B) 10% to 20% 
C) 20% to 50% 
D) 50% to 100% 
A) 5% to 10% 
B) 10% to 20% 
C) 20% to 50% 
D) 50% to 100%

Question 16

Which of the following stages of infectious mononucleosis infection is characterized by antibody to Epstein-Barr nuclear antigen (EBNA)?

Accepted Answer

A) Recent (acute) infection 
B) Past infection (convalescent) period 
C) Reactivation of latent infection 
D) Both B and C. 
A) Recent (acute) infection 
B) Past infection (convalescent) period 
C) Reactivation of latent infection 
D) Both B and C.

Question 17

A more recent methodology used to detect antibodies to EBNA is

Accepted Answer

A) monospot. 
B) monoslide. 
C) ELISA. 
D) immunofluorescence. 
A) monospot. 
B) monoslide. 
C) ELISA. 
D) immunofluorescence.

Question 18

The MonoSlide test is based on the agglutination of

Accepted Answer

A) sheep erythrocytes. 
B) horse erythrocytes. 
C) latex-coated particles. 
D) guinea pig antigen. 
A) sheep erythrocytes. 
B) horse erythrocytes. 
C) latex-coated particles. 
D) guinea pig antigen.

Question 19

EBV is typically manifested by

Accepted Answer

A) young children. 
B) young adults. 
C) middle-aged individuals. 
D) older adults. 
A) young children. 
B) young adults. 
C) middle-aged individuals. 
D) older adults.

Question 20

EBV is transmitted primarily by

Accepted Answer

A) close contact with infectious oropharyngeal secretions. 
B) blood transfusion. 
C) transplacental exposure. 
D) transplanted organs or tissues. 
A) close contact with infectious oropharyngeal secretions. 
B) blood transfusion. 
C) transplacental exposure. 
D) transplanted organs or tissues.

Exam 21: Infectious Mononucleosis

Immunocompetent individuals maintain EBV as a(n)

A blood transfusion from an immune donor to a nonimmune recipient may produce

Match each procedure to the appropriate description. -Davidsohn differential test

Match each procedure to the appropriate description. -Paul-Bunnell screening test

Immunoglobulin M (IgM) heterophile antibody is characterized by no absorption by beef erythrocytes.

The use of horse erythrocytes in rapid slide tests for infectious mononucleosis increases the

Epstein-Barr virus (EBV) is

Viral capsid antigen (VCA) is produced by

Anti-VCA immunoglobulin G (IgG) is usually detectable within

All the following statements about Epstein-Barr virus (EBV) are true except that it

Immunoglobulin M (IgM) heterophile antibody is characterized by reaction with horse, ox, and sheep erythrocytes.

Match each procedure to the appropriate description. -MonoSlide agglutination test

In rapid MonoSlide testing, a false-positive result can be caused by

In infectious mononucleosis, EBV

In the adult population, ________ of individuals with acute infectious mononucleosis do not produce heterophile antibodies.

Which of the following stages of infectious mononucleosis infection is characterized by antibody to Epstein-Barr nuclear antigen (EBNA)?

A more recent methodology used to detect antibodies to EBNA is

The MonoSlide test is based on the agglutination of

EBV is typically manifested by

EBV is transmitted primarily by

An Overview of Immunology

Antigens and Antibodies

Cells and Cellular Activities of the Immune System: Granulocytes and Mononuclear Cells

Cells and Cellular Activities of the Immune System: Lymphocytes and Plasma Cells

Soluble Mediators of the Immune System

Safety in the Immunology-Serology Laboratory

Quality Assurance and Quality Control

Basic Serologic Laboratory Techniques

Rapid Testing

Precipitation and Particle Agglutination Methods

Electrophoresis Techniques

Labeling Techniques in Immunoassay

Flow Cytometry

Molecular Laboratory Techniques

Infectious Diseases: Traditional and Alternate Diagnostic Techniques

Streptococcal Infections

Syphilis

Vector-Borne Diseases

Toxoplasmosis

Cytomegalovirus

Viral Hepatitis

Rubella and Rubeola Infections

Primary and Acquired Immune Deficiency Syndromes

Hypersensitivity Reactions

Immunoproliferative Disorders

Tolerance, Autoimmunity, and Autoimmune Diseases

Systemic Lupus Erythematosus

Rheumatoid Arthritis

Transplantation: Hla, Solid Organ, and Hematopoietic Stem Cells

Tumor Immunology and Up-To-Date Applications of Next-Generation Sequencing

Primer on Vaccines

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