Exam 10: Viral Genomics, Diversity, and Ecology

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Describe the hypothesis of viruses occurring before living cells and how DNA might have evolved. What is the current hypothesis about the evolutionary relationships between RNA, DNA, viruses, and cellular life?

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A drug designed to inhibit reverse transcriptase activity would target

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A bacteriophage that lacks its proteinaceous capsid structure is also called a viroid.

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Unusually shaped viruses, such as lemon-shaped and spindle-shaped, have recently been discovered in

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The family of reoviruses contain dsRNA genomes use a ________ replication process.

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The ________ has been especially useful for genetic engineering because it is capable of triggering a substantial immune response without causing major adverse health effects.

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Among the largest RNA genome viruses are ________ which contain a ________ genome.

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Genomics analysis of recently isolated viruses indicate that some viruses contain larger genomes than some bacterial genomes.

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Bacteriophages that have single-stranded genomes are specialized to minimize energy requirements because just one strand is necessary for replication.

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Due to their indispensible role for copying its genome, an intracellular host protease that attacks the adenoviral protein ends would likely result in halting its replication.

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The hepadnavirus DNA polymerase acts as which of the following?

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Despite viruses require a living hostʹs metabolism to replicate, it remains unclear whether viruses existed before living cells.

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One hypothesis on the origin of DNA points to RNA viruses evolving a modified nucleotide that is insensitive to ribonucleases.

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Many viruses that infect humans may illicit a strong immune response causing additional harmful effects, so the discovery of a virus that can induce an immune response without causing harm made it attractive for vaccine development.

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Why are phylogenetic studies of viruses more challenging than Bacteria? Explain how genes are selected in viruses for phylogeny and the constraints those create.

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Nonfilamentous bacteriophages often can escape its host without lysing, whereas filamentous phages normally induce cell lysis once replicated inside their host.

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The phage Mu

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What will happen if the Mu repressor is NOT synthesized?

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Describe how bacteriophages influence the oceans' bacterial populations and nutrient cycling.

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Due to the genetic diversity of viruses and their lack of ribosomal RNA, nucleotide-based phylogeny studies are not applicable to virology.

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