Exam 17: The Immune Response

You are studying a weasel and find that its genome contains 7 J_κ and 55 V_κ genes. Assuming that any V sequence can join with any J sequence, how many different kappa chains can this organism make?

Which of the following drugs is often used to help prevent rejection of a tissue transplant?

Which of the following is a true statement regarding an MHC class II molecule? It possesses __________________.

The heavy chains of which class of antibody bind and activate one of the complement system proteins, leading to the lysis of the bacterial cell to which the antibody molecules are bound?

How is the material ingested by dendritic cells fragmented?

All types of immune responses are based upon ___________.

MHC class II proteins are synthesized as _____________.

Nucleotide sequence analysis of the V genes indicate that they are ________ than required to encode the V region of the κ light chain.

What determines the specificity of an antibody?

Where do dendritic cells go once they have processed antigens and what do they do when they get there?

Which cells of the immune system produce an interleukin, which is thought to stimulate epithelial cells to recruit phagocytes and thereby prevent the entry of extracellular bacteria and fungi into the body?

When an antigen binds to the antibody in the membrane of a B cell, the B cell proliferates and forms a population of B lymphocytes that all make the same antibody. The population of B lymphocytes thus formed is called ________.

Which of the following is NOT a protein produced by virus-infected cells and secreted into the extracellular space where they bind to the surface of noninfected cells rendering them resistant to subsequent infection?

What causes inflammation at the site of an infection?

What subfamily of small cytokines acts primarily as chemoattractants that stimulate the migration of lymphocytes into inflamed tissue?

While the hypervariable regions of the light and heavy chains determine an antibody's combining site specificity, the remaining portions of the variable regions perform the function of ____________.

The foreign molecules that stimulate the adaptive immune system to make antibodies are called ________.

Genes encoding antibodies are generated by a process in which DNA segments are _______ combined.

Which antibodies are the first to be secreted by B cells after antigen stimulation, appear in the blood after a lag of a few days, and have a relatively short half-life?

The heavy chains of which class of antibody bind specifically to macrophage and neutrophil surface receptors, inducing these phagocytes to ingest the particle to which the antibodies are bound?