Question 1

What types of amino acids are most responsible for the binding of DNA to histones?

Accepted Answer

A)  Hydrophobic amino acids 
B)  Polar amino acids 
C)  Positively charged amino acids 
D)  Negatively charged amino acids 
A)  Hydrophobic amino acids 
B)  Polar amino acids 
C)  Positively charged amino acids 
D)  Negatively charged amino acids

Question 2

The term genome refers to the complete complement of sequences and genes that an organism
possesses.

Accepted Answer

A) True 
 B)False

Question 3

In a self assembly virus, the viral genome contains instructions for noncapsid proteins that aid in the assembly of the virus.

Accepted Answer

A) True 
 B)False

Question 4

Each radial loop domain may contain between 10 and 100 base pairs of DNA.

Accepted Answer

A) True 
 B)False

Question 5

The DNA of a bacterial cell must be compacted about fold to fit within the confines of the cell.

Accepted Answer

A)  10 
B)  100 
C)  150 
D)  1000 
E)  1,000,000 
A)  10 
B)  100 
C)  150 
D)  1000 
E)  1,000,000

Question 6

The majority of the nonrepetitive genes in an organism are found in which of the following?

Accepted Answer

A)  Unique sequences 
B)  Moderately repetitive sequences 
C)  Highly repetitive sequences 
D)  None of the answers are correct 
A)  Unique sequences 
B)  Moderately repetitive sequences 
C)  Highly repetitive sequences 
D)  None of the answers are correct

Question 7

The zig-zag and solenoid models are associated with the level of DNA organization.

Accepted Answer

A)  histone 
B)  11nm fiber 
C)  beads-on-a-string 
D)  30 nm fiber 
E)  scaffold protein 
A)  histone 
B)  11nm fiber 
C)  beads-on-a-string 
D)  30 nm fiber 
E)  scaffold protein

Question 8

How many origins of replication are there in bacteria?

Accepted Answer

A)  0 
B)  1 
C)  2 
D)  More than two 
A)  0 
B)  1 
C)  2 
D)  More than two

Question 9

Chemicals such as quinolones are anti-bacterial. How does it kill bacteria?

Accepted Answer

A)  It inhibits DNA gyrase 
B)  It inhibits DNA compaction 
C)  It inhibits DNA replication 
D)  All of the answers are correct 
A)  It inhibits DNA gyrase 
B)  It inhibits DNA compaction 
C)  It inhibits DNA replication 
D)  All of the answers are correct

Question 10

The 30 nm fiber is formed from arrays of nucleosomes.

Accepted Answer

A) True 
 B)False

Question 11

The different DNA configurations that are generated by super coiling are called topoisomers of one
another.

Accepted Answer

A) True 
 B)False

Question 12

A nucleosome is a combination of and .

Accepted Answer

A)  histone proteins, scaffold proteins 
B)  RNA, transcription proteins 
C)  DNA, histone proteins 
D)  RNA, histone proteins 
E)  DNA, scaffold proteins 
A)  histone proteins, scaffold proteins 
B)  RNA, transcription proteins 
C)  DNA, histone proteins 
D)  RNA, histone proteins 
E)  DNA, scaffold proteins

Question 13

Which of the following NOT a mechanism used by bacteria to condense their DNA?

Accepted Answer

A)  Super coiling 
B)  Packaging the DNA with histone proteins 
C)  Looping of the DNA 
D)  Increase or decrease the number of turns in the DNA 
E)  Anchoring the DNA loops with DNA-binding proteins 
A)  Super coiling 
B)  Packaging the DNA with histone proteins 
C)  Looping of the DNA 
D)  Increase or decrease the number of turns in the DNA 
E)  Anchoring the DNA loops with DNA-binding proteins

Question 14

The DNA-protein complex in eukaryotic chromosomes is called the genome.

Accepted Answer

A) True 
 B)False

Question 15

Which of the following is correctly matched with its description?

Accepted Answer

A)  Highly repetitive DNA contains transposable elements and genes that expressed in abundance and thus have many copies. 
B)  Moderately repetitive DNA contains unique sequences, such as genes found in one or a few copies. 
C)  Non-repetitive DNA is composed of thousands of copies of many short repeats. 
D)  Moderately repetitive DNA contains retro elements, such as the Alu sequence. 
E)  Moderately repetitive DNA contains transposable elements and genes that expressed in abundance and thus have many copies. 
A)  Highly repetitive DNA contains transposable elements and genes that expressed in abundance and thus have many copies. 
B)  Moderately repetitive DNA contains unique sequences, such as genes found in one or a few copies. 
C)  Non-repetitive DNA is composed of thousands of copies of many short repeats. 
D)  Moderately repetitive DNA contains retro elements, such as the Alu sequence. 
E)  Moderately repetitive DNA contains transposable elements and genes that expressed in abundance and thus have many copies.

Question 16

Digestion with a low concentration of DNAse I would yield fragments of what approximate size?

Accepted Answer

A)  200 
B)  400 
C)  600 
D)  1100 
A)  200 
B)  400 
C)  600 
D)  1100

Question 17

The majority of bacterial DNA is negatively super coiled.

Accepted Answer

A) True 
 B)False

Question 18

Which of the following is found at the end of a eukaryotic chromosome?

Accepted Answer

A)  Telomeres 
B)  Centromeres 
C)  Kinetochores 
D)  Origins of replication 
A)  Telomeres 
B)  Centromeres 
C)  Kinetochores 
D)  Origins of replication

Question 19

DNA topoisomerase I does which of the following?

Accepted Answer

A)  Introduce positive super coils 
B)  Relieve positive super coils 
C)  Introduce negative super coils 
D)  More than one of the above 
A)  Introduce positive super coils 
B)  Relieve positive super coils 
C)  Introduce negative super coils 
D)  More than one of the above

Question 20

A Cot curve can be used to determine .

Accepted Answer

A)  The sequence complexity of a given organism 
B)  The total concentration of DNA in a cell 
C)  The number of origins of replication 
D)  The length of the chromosome in base pairs 
A)  The sequence complexity of a given organism 
B)  The total concentration of DNA in a cell 
C)  The number of origins of replication 
D)  The length of the chromosome in base pairs

Exam 10: Chromosome Organization and Molecular Structure

What types of amino acids are most responsible for the binding of DNA to histones?

The term genome refers to the complete complement of sequences and genes that an organism possesses.

In a self assembly virus, the viral genome contains instructions for noncapsid proteins that aid in the assembly of the virus.

Each radial loop domain may contain between 10 and 100 base pairs of DNA.

The DNA of a bacterial cell must be compacted about fold to fit within the confines of the cell.

The majority of the nonrepetitive genes in an organism are found in which of the following?

The zig-zag and solenoid models are associated with the level of DNA organization.

How many origins of replication are there in bacteria?

Chemicals such as quinolones are anti-bacterial. How does it kill bacteria?

The 30 nm fiber is formed from arrays of nucleosomes.

The different DNA configurations that are generated by super coiling are called topoisomers of one another.

A nucleosome is a combination of and .

Which of the following NOT a mechanism used by bacteria to condense their DNA?

The DNA-protein complex in eukaryotic chromosomes is called the genome.

Which of the following is correctly matched with its description?

Digestion with a low concentration of DNAse I would yield fragments of what approximate size?

The majority of bacterial DNA is negatively super coiled.

Which of the following is found at the end of a eukaryotic chromosome?

DNA topoisomerase I does which of the following?

A Cot curve can be used to determine .

Overview of Genetics

Mendelian Inheritance

Reproduction and Chromosome Transmission

Extensions of Mendelian Inheritance

Non-Mendelian Inheritance

Genetic Linkage and Mapping in Eukaryotes

Genetic Transfer and Mapping in Bacteria and

Variation in Chromosome Structure and Number

Molecular Structure of Dna and Rna

Dna Replication

Gene Transcription and Rna Modification

Translation of Mrna

Gene Regulation in Bacteria and Bacteriophages

Gene Regulation in Eukaryotes

Gene Mutation and Dna Repair

Recombination and Transposition at the Molecular

Recombinant Dna Technology

Biotechnology

Genomics I: Analysis of Dna

Genomics II: Functional Genomics, Proteomics, and

Medical Genetics and Cancer

Developmental Genetics

Population Genetics

Quantitative Genetics

Evolutionary Genetics

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