Question 1

A lod score of is accepted by most geneticists to indicate that two genes are linked.

Accepted Answer

A)  0 
B)  1 
C)  2 
D)  3 
E)  4 
A)  0 
B)  1 
C)  2 
D)  3 
E)  4 D

Question 2

RFLP stands for restriction fragment linked position.

Accepted Answer

A) True 
 B)False  False

Question 3

The method of sequencing genomic fragments cloned straight from the genome is:

Accepted Answer

A)  Cytogenetic mapping 
B)  Whole genome shotgun sequencing 
C)  Hierarchical shotgun sequencing 
D)  Southern blotting 
E)  Dideoxy blotting 
A)  Cytogenetic mapping 
B)  Whole genome shotgun sequencing 
C)  Hierarchical shotgun sequencing 
D)  Southern blotting 
E)  Dideoxy blotting C

Question 4

involves an examination of how the proteins encoded by genes interact to produce cell and tissue types.

Accepted Answer

A)  Proteomics 
B)  Functional genomics 
C)  Structural genomics 
D)  Genomics 
A)  Proteomics 
B)  Functional genomics 
C)  Structural genomics 
D)  Genomics

Question 5

Which of the following procedures best determines the relative order, but not precise location, of a series of genes on a chromosome?

Accepted Answer

A)  Physical mapping 
B)  Cytogenetic mapping 
C)  Linkage mapping 
D)  All of the answers are correct 
A)  Physical mapping 
B)  Cytogenetic mapping 
C)  Linkage mapping 
D)  All of the answers are correct

Question 6

An amplified restriction fragment length polymorphism is a combination of the procedures for
producing RFLP and STS markers.

Accepted Answer

A) True 
 B)False

Question 7

A site that has variation within the members of the population is said to be .

Accepted Answer

A)  Monomorphic 
B)  Polymorphic 
C)  Trimorphic 
D)  None of the answers are correct 
A)  Monomorphic 
B)  Polymorphic 
C)  Trimorphic 
D)  None of the answers are correct

Question 8

A is a combination of a plasmid vector and phage I.

Accepted Answer

A)  contig 
B)  artificial chromosome 
C)  cosmid 
D)  positional clone 
E)  transposable element 
A)  contig 
B)  artificial chromosome 
C)  cosmid 
D)  positional clone 
E)  transposable element

Question 9

A map unit distance always corresponds to 106 base pairs.

Accepted Answer

A) True 
 B)False

Question 10

Which of the following may be used to clone a gene based upon its mapped position along a chromosome?

Accepted Answer

A)  Sub cloning 
B)  Chromosome walking 
C)  Positional cloning 
D)  All of the answers are correct 
A)  Sub cloning 
B)  Chromosome walking 
C)  Positional cloning 
D)  All of the answers are correct

Question 11

Which of the following is not a model organism under study by the Human Genome Project?

Accepted Answer

A)  Drosophila melanogaster 
B)  Homo sapiens 
C)  Escherichia coli 
D)  Arabidopsis thalania 
E)  All of the answers are currently being studied 
A)  Drosophila melanogaster 
B)  Homo sapiens 
C)  Escherichia coli 
D)  Arabidopsis thalania 
E)  All of the answers are currently being studied

Question 12

BAC stands for bacterial artificial chromosome.

Accepted Answer

A) True 
 B)False

Question 13

Which of the following is NOT true regarding YACs?

Accepted Answer

A)  YAC stands for yeast artificial cosmid. 
B)  They are used to clone large sections of eukaryotic chromosomes. 
C)  They contain DNA fragments much larger than conventional vectors. 
D)  They make it easier to construct a contig of a chromosome. 
E)  All of the above are true. 
A)  YAC stands for yeast artificial cosmid. 
B)  They are used to clone large sections of eukaryotic chromosomes. 
C)  They contain DNA fragments much larger than conventional vectors. 
D)  They make it easier to construct a contig of a chromosome. 
E)  All of the above are true.

Question 14

The process of in situ hybridization is used for which of the following ?

Accepted Answer

A)  Cytogenetic mapping 
B)  Physical mapping 
C)  Linkage mapping 
D)  None of the answers are correct 
A)  Cytogenetic mapping 
B)  Physical mapping 
C)  Linkage mapping 
D)  None of the answers are correct

Question 15

Comparative genomics attempts to define evolutionary relationships.

Accepted Answer

A) True 
 B)False

Question 16

Cytogenetic mapping is accurate to within 500,000 base pairs, but not over this value.

Accepted Answer

A) True 
 B)False

Question 17

What does physical mapping provide that the other types of genetic mapping do not?

Accepted Answer

A)  Recombination distances between genes 
B)  Number of nucleotide base-pairs between genes 
C)  Relationship of the gene to specific chromosomal banding patterns 
D)  All of the answers are correct 
A)  Recombination distances between genes 
B)  Number of nucleotide base-pairs between genes 
C)  Relationship of the gene to specific chromosomal banding patterns 
D)  All of the answers are correct

Question 18

An RFLP marker may be used to predict the likelihood that an individual carries a trait for a specific
disease.

Accepted Answer

A) True 
 B)False

Question 19

In a FISH procedure, the probe being used is labeled with a fluorescent tag.

Accepted Answer

A) True 
 B)False

Question 20

The human genome consists of approximately base pairs of DNA.

Accepted Answer

A)  100,000 
B)  1 million 
C)  1 billion 
D)  3 billion 
E)  2 trillion 
A)  100,000 
B)  1 million 
C)  1 billion 
D)  3 billion 
E)  2 trillion

Exam 20: Genomics I: Analysis of Dna

A lod score of is accepted by most geneticists to indicate that two genes are linked.

RFLP stands for restriction fragment linked position.

The method of sequencing genomic fragments cloned straight from the genome is:

involves an examination of how the proteins encoded by genes interact to produce cell and tissue types.

Which of the following procedures best determines the relative order, but not precise location, of a series of genes on a chromosome?

An amplified restriction fragment length polymorphism is a combination of the procedures for producing RFLP and STS markers.

A site that has variation within the members of the population is said to be .

A is a combination of a plasmid vector and phage I.

A map unit distance always corresponds to 106 base pairs.

Which of the following may be used to clone a gene based upon its mapped position along a chromosome?

Which of the following is not a model organism under study by the Human Genome Project?

BAC stands for bacterial artificial chromosome.

Which of the following is NOT true regarding YACs?

The process of in situ hybridization is used for which of the following ?

Comparative genomics attempts to define evolutionary relationships.

Cytogenetic mapping is accurate to within 500,000 base pairs, but not over this value.

What does physical mapping provide that the other types of genetic mapping do not?

An RFLP marker may be used to predict the likelihood that an individual carries a trait for a specific disease.

In a FISH procedure, the probe being used is labeled with a fluorescent tag.

The human genome consists of approximately base pairs of DNA.

Overview of Genetics

Mendelian Inheritance

Reproduction and Chromosome Transmission

Extensions of Mendelian Inheritance

Non-Mendelian Inheritance

Genetic Linkage and Mapping in Eukaryotes

Genetic Transfer and Mapping in Bacteria and

Variation in Chromosome Structure and Number

Molecular Structure of Dna and Rna

Chromosome Organization and Molecular Structure

Dna Replication

Gene Transcription and Rna Modification

Translation of Mrna

Gene Regulation in Bacteria and Bacteriophages

Gene Regulation in Eukaryotes

Gene Mutation and Dna Repair

Recombination and Transposition at the Molecular

Recombinant Dna Technology

Biotechnology

Genomics II: Functional Genomics, Proteomics, and

Medical Genetics and Cancer

Developmental Genetics

Population Genetics

Quantitative Genetics

Evolutionary Genetics

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