Question 1

DNA damage is sensed by E2F at the G1 and G2 checkpoints.

Accepted Answer

A) True 
 B)False  False

Question 2

After genetic testing, a person is identified with an inherited mutation associated with a specific class of cancer. Which of the following is incorrect?

Accepted Answer

A)  The person will definitely develop the cancer in their lifetimes 
B)  The person is predisposed to the development of the cancer 
C)  The mutation is probably in a tumor-suppressing gene 
D)  The person may pass the trait on to their offspring 
A)  The person will definitely develop the cancer in their lifetimes 
B)  The person is predisposed to the development of the cancer 
C)  The mutation is probably in a tumor-suppressing gene 
D)  The person may pass the trait on to their offspring A

Question 3

Which of the following prior conformations may result in a prion-related infection?

Accepted Answer

A)  PrPSc 
B)  PrPC 
C)  Both can cause disease 
A)  PrPSc 
B)  PrPC 
C)  Both can cause disease A

Question 4

A oncogene may promote cancer by keeping the cell growth pathway in the off position.

Accepted Answer

A) True 
 B)False

Question 5

Burkitt's lymphoma is an example of a proto-oncogene activation by .

Accepted Answer

A)  Action of a virus 
B)  Missense mutation 
C)  A translocation 
D)  Gene amplification 
E)  None of the answers are correct 
A)  Action of a virus 
B)  Missense mutation 
C)  A translocation 
D)  Gene amplification 
E)  None of the answers are correct

Question 6

Cancer is considered clonal because daughter cells from a cancer cell have the same genetic makeup
as the parent cell.

Accepted Answer

A) True 
 B)False

Question 7

A mutation in which of the following genes would enhance the chances of cancer?

Accepted Answer

A)  p53 
B)  ras 
C)  myc 
D)  Rb 
E)  All of the answers are correct 
A)  p53 
B)  ras 
C)  myc 
D)  Rb 
E)  All of the answers are correct

Question 8

The majority of human cancers are caused by .

Accepted Answer

A)  Viral infections 
B)  Inherited mutations 
C)  Spontaneous mutations 
D)  Carcinogens 
A)  Viral infections 
B)  Inherited mutations 
C)  Spontaneous mutations 
D)  Carcinogens

Question 9

Which of the following would indicate that a disease has a genetic, rather than environmental, cause?

Accepted Answer

A)  The disease has a specific age of onset 
B)  A high level of concordance among monozygotic twins 
C)  The disease does not occur in individuals that are exposed to a similar environment 
D)  The disease is similar to a known genetic disease in an animal such as a mouse 
E)  All of the answers are correct 
A)  The disease has a specific age of onset 
B)  A high level of concordance among monozygotic twins 
C)  The disease does not occur in individuals that are exposed to a similar environment 
D)  The disease is similar to a known genetic disease in an animal such as a mouse 
E)  All of the answers are correct

Question 10

An oncogene form of Ras would have which of the following characteristics?

Accepted Answer

A)  Decreased GTPase activity 
B)  An increased number of copies in the cell 
C)  Increased susceptibility to growth factors 
D)  None of the answers are correct 
A)  Decreased GTPase activity 
B)  An increased number of copies in the cell 
C)  Increased susceptibility to growth factors 
D)  None of the answers are correct

Question 11

A disease that can be caused by mutations in different genes is said to have homogeneity.

Accepted Answer

A) True 
 B)False

Question 12

An infectious agent that is comprised entirely of proteins is called a prion.

Accepted Answer

A) True 
 B)False

Question 13

Dizygotic twins share of their genetic information.

Accepted Answer

A)  25% 
B)  50% 
C)  75% 
D)  100% 
A)  25% 
B)  50% 
C)  75% 
D)  100%

Question 14

The process of removes amniotic fluid from a pregnant mother to examine fetal cells for genetic problems.

Accepted Answer

A)  aminocentesis 
B)  chorionic villus sampling 
C)  preimplantation genetic diagnosis 
D)  in vitro fertilization 
A)  aminocentesis 
B)  chorionic villus sampling 
C)  preimplantation genetic diagnosis 
D)  in vitro fertilization

Question 15

A disease that is lethal in the homozygous condition is most likely which of the following?

Accepted Answer

A)  Autosomal recessive 
B)  Autosomal dominant 
C)  X-linked 
D)  None of the answers are correct 
A)  Autosomal recessive 
B)  Autosomal dominant 
C)  X-linked 
D)  None of the answers are correct

Question 16

In a disease that has a single gene, the concordance among monozygotic twins should be .

Accepted Answer

A)  0% 
B)  25% 
C)  50% 
D)  75% 
E)  100% 
A)  0% 
B)  25% 
C)  50% 
D)  75% 
E)  100%

Question 17

An environmental agent that causes cancer is called a .

Accepted Answer

A)  carcinogen 
B)  malignant agent 
C)  invasive agent 
D)  metastatic agent 
A)  carcinogen 
B)  malignant agent 
C)  invasive agent 
D)  metastatic agent

Question 18

Which of the following is not associated with an autosomal dominant pattern of inheritance?

Accepted Answer

A)  An affected offspring has one or more affected parents 
B)  An affected individual with one affected parent will have 50% of its offspring affected 
C)  Two affected heterozygous individuals will have 25% of their offspring unaffected 
D)  An affected offspring has two unaffected parents 
A)  An affected offspring has one or more affected parents 
B)  An affected individual with one affected parent will have 50% of its offspring affected 
C)  Two affected heterozygous individuals will have 25% of their offspring unaffected 
D)  An affected offspring has two unaffected parents

Question 19

In a disease that is associated with a single recessive allele, the concordance among dizygotic twins should be .

Accepted Answer

A)  0% 
B)  25% 
C)  50% 
D)  75% 
E)  100% 
A)  0% 
B)  25% 
C)  50% 
D)  75% 
E)  100%

Question 20

A pedigree analysis is the study of family trees to establish patterns of inheritance.

Accepted Answer

A) True 
 B)False

Exam 22: Medical Genetics and Cancer

DNA damage is sensed by E2F at the G1 and G2 checkpoints.

After genetic testing, a person is identified with an inherited mutation associated with a specific class of cancer. Which of the following is incorrect?

Which of the following prior conformations may result in a prion-related infection?

A oncogene may promote cancer by keeping the cell growth pathway in the off position.

Burkitt's lymphoma is an example of a proto-oncogene activation by .

Cancer is considered clonal because daughter cells from a cancer cell have the same genetic makeup as the parent cell.

A mutation in which of the following genes would enhance the chances of cancer?

The majority of human cancers are caused by .

Which of the following would indicate that a disease has a genetic, rather than environmental, cause?

An oncogene form of Ras would have which of the following characteristics?

A disease that can be caused by mutations in different genes is said to have homogeneity.

An infectious agent that is comprised entirely of proteins is called a prion.

Dizygotic twins share of their genetic information.

The process of removes amniotic fluid from a pregnant mother to examine fetal cells for genetic problems.

A disease that is lethal in the homozygous condition is most likely which of the following?

In a disease that has a single gene, the concordance among monozygotic twins should be .

An environmental agent that causes cancer is called a .

Which of the following is not associated with an autosomal dominant pattern of inheritance?

In a disease that is associated with a single recessive allele, the concordance among dizygotic twins should be .

A pedigree analysis is the study of family trees to establish patterns of inheritance.

Overview of Genetics

Mendelian Inheritance

Reproduction and Chromosome Transmission

Extensions of Mendelian Inheritance

Non-Mendelian Inheritance

Genetic Linkage and Mapping in Eukaryotes

Genetic Transfer and Mapping in Bacteria and

Variation in Chromosome Structure and Number

Molecular Structure of Dna and Rna

Chromosome Organization and Molecular Structure

Dna Replication

Gene Transcription and Rna Modification

Translation of Mrna

Gene Regulation in Bacteria and Bacteriophages

Gene Regulation in Eukaryotes

Gene Mutation and Dna Repair

Recombination and Transposition at the Molecular

Recombinant Dna Technology

Biotechnology

Genomics I: Analysis of Dna

Genomics II: Functional Genomics, Proteomics, and

Developmental Genetics

Population Genetics

Quantitative Genetics

Evolutionary Genetics

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