Exam 5: Aerobic Respiration and the Mitochondrion

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Which of the following regulate intracellular levels of Ca2+ ions?

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What is the terminal electron acceptor of the electron transport chain?

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Explain why fast-twitch fibers "prefer" to use anaerobic respiration rather than aerobic respiration even though aerobic respiration is about 20 times more efficient in terms of ATP produced per glucose molecule?

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What properties do mitochondria share with peroxisomes?

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A patient who has abnormal mitochondria has the following symptoms: long-term fatigue and muscle weakness,elevated metabolic rate and body temperature.Studies indicate that the mitochondria have been released from their normal respiratory control.How does this explain the elevated temperature? Why are most disorders that have been traced to mitochondrial dysfunction characterized by degeneration of muscle or brain tissue? What are the characteristics of some of the conditions that result from dysfunctional mitochondria?

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Which mitochondrial genes when mutated or experiencing deletions cause the most serious disorders?

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You treat some cells with DNP and discover that ATP production ceases.Upon closer examination,you also note that the number of calcium ions sequestered in the mitochondrion decreases.Please explain.

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What is the basis of adrenoleukodystrophy (ALD)and other similar diseases?

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How many carbons from an original glucose molecule get into the TCA cycle? What happens to the carbons that do not enter the cycle?

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What treatments have been tried to help ALD patients?

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Observations of two different cell types indicate a couple of differences in their mitochondria.Cell type 1 has 2-3 times the mitochondria of Cell Type 2.The mitochondria in Cell Type 1 are also larger,contain more cristae and the cristae extend farther across the mitochondria than in Cell Type 2.Which cell type is likely to have more extensive energy requirements?

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In the early 1980s,a number of young drug addicts showed up in hospitals with the sudden onset of severe muscular tremors that are characteristic of advanced Parkinson's disease (PD)in elderly adults.What caused these PD-like symptoms in such young people? How were the cells of the substantia nigra in PD patients similar to those in the substantia nigra of MPTP patients? What are some possible environmental causes of PD?

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An unusual type of phospholipid is found in the myelin sheath that insulates brain axons;abnormalities in the synthesis of this phospholipid can lead to severe neurological dysfunction.What are these phospholipids called?

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Where are most of the enzymes of the Krebs cycle located?

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What molecule is responsible for conveying 2 carbons from pyruvate to the Krebs cycle?

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What type of electron carrier has a prosthetic group derived from vitamin B2?

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You prepare red blood cell ghosts with a very high internal potassium ion concentration and a very high external sodium ion concentration,higher than normally exists in the body.The red blood cell ghost also contains ADP and inorganic phosphate ions in the interior and the Na+-K+ pump in the membrane.What happens?

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Which lipid is known for playing an important role in facilitating the activity of proteins involved in ATP synthesis?

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The three catalytic sites of ATP synthase ___________.

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Which enzyme of the Krebs (TCA)cycle is different from the others with respect to its location and where is it located?

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