Question 1

Autoimmune activity may be unleashed as a result of infection due to

Accepted Answer

A)  molecular mimicry 
B)  unmasking of cryptic self-antigen 
C)  activation of co-stimulatory signaling 
D)  all of the above 
A)  molecular mimicry 
B)  unmasking of cryptic self-antigen 
C)  activation of co-stimulatory signaling 
D)  all of the above D

Question 2

Autoimmune attack may be initiated by a failure

Accepted Answer

A)  to delete autoreactive B and T cells 
B)  to clear immune complexes 
C)  of complement fixation to antibody-bound antigen 
D)  all of the above 
A)  to delete autoreactive B and T cells 
B)  to clear immune complexes 
C)  of complement fixation to antibody-bound antigen 
D)  all of the above D

Question 3

Which of the following is true about the impact of psychosocial factors on cancer

Accepted Answer

A)  psychosocial factors are irrelevant 
B)  animal studies support the relevance of psychosocial factors 
C)  research on cervical cancer has not provided any evidence of impact 
D)  only cancers without viral etiology can be affected 
A)  psychosocial factors are irrelevant 
B)  animal studies support the relevance of psychosocial factors 
C)  research on cervical cancer has not provided any evidence of impact 
D)  only cancers without viral etiology can be affected B

Question 4

Which of the following is false in the case of SLE

Accepted Answer

A)  it afflicts females most of all during the child bearing years 
B)  its incidence is identical across racial/ethnic groups 
C)  genetic predictors of risk include HLA class II molecules 
D)  several distinct single neuclotide polymorphisms are associated with SLE risk 
A)  it afflicts females most of all during the child bearing years 
B)  its incidence is identical across racial/ethnic groups 
C)  genetic predictors of risk include HLA class II molecules 
D)  several distinct single neuclotide polymorphisms are associated with SLE risk

Question 5

The effect of psychosocial stress on cancer

Accepted Answer

A)  has been amply demonstrated 
B)  remains the major focus of the research 
C)  has been difficult to establish due to the heterogeneity of cancers 
D)  appears secondary to access to care 
A)  has been amply demonstrated 
B)  remains the major focus of the research 
C)  has been difficult to establish due to the heterogeneity of cancers 
D)  appears secondary to access to care

Question 6

Research on immune activity and cancer survival

Accepted Answer

A)  has been focused mostly on NK activity 
B)  has found support for higher NK activity being beneficial 
C)  has found support for lower NK activity being beneficial 
D)  all of the above 
A)  has been focused mostly on NK activity 
B)  has found support for higher NK activity being beneficial 
C)  has found support for lower NK activity being beneficial 
D)  all of the above

Question 7

Which of the following is true in the case of rheumatoid arthritis

Accepted Answer

A)  onset is always gradual 
B)  psychosocial stress has not been found to have an impact 
C)  monozygotic twins show concordances in excess of 70% 
D)  prevalence is affected by socioeconomic status 
A)  onset is always gradual 
B)  psychosocial stress has not been found to have an impact 
C)  monozygotic twins show concordances in excess of 70% 
D)  prevalence is affected by socioeconomic status

Question 8

Extraversion, a personality characteristic associated with positive affeect

Accepted Answer

A)  protects against cancer 
B)  has a paradoxic effect on cancer risk 
C)  increases the risk of melanoma 
D)  has no predictive value with respect to cncer risk 
A)  protects against cancer 
B)  has a paradoxic effect on cancer risk 
C)  increases the risk of melanoma 
D)  has no predictive value with respect to cncer risk

Question 9

Primary defense against cancer appear to be

Accepted Answer

A)  immune attack 
B)  DNA repair 
C)  activation of cell-death mechanisms 
D)  both b and c 
A)  immune attack 
B)  DNA repair 
C)  activation of cell-death mechanisms 
D)  both b and c

Question 10

Adverse psychosocial experiences in early life

Accepted Answer

A)  are not predictive with respect to autoimmune disorders in general 
B)  appear to be protective against autoimmune disorders 
C)  increase likelihood of hospitalization in adulthood for autoimmune disorders 
D)  decrease the risk of autoimmune disorders in males only 
A)  are not predictive with respect to autoimmune disorders in general 
B)  appear to be protective against autoimmune disorders 
C)  increase likelihood of hospitalization in adulthood for autoimmune disorders 
D)  decrease the risk of autoimmune disorders in males only

Question 11

Psychosocial stress has been found to be less clearly associated with

Accepted Answer

A)  multiple sclerosis 
B)  insulin-dependemt diabetes 
C)  inflammatory bowel disease 
D)  systemic lupus erythematosus 
A)  multiple sclerosis 
B)  insulin-dependemt diabetes 
C)  inflammatory bowel disease 
D)  systemic lupus erythematosus

Question 12

The observation that a self-antigen present in multiple organs may be the target of autoimmunity in only one organ

Accepted Answer

A)  has been called autophagy 
B)  is prove that single genetic loci are involved 
C)  underscores the importance of microenvironmental triggers 
D)  proves that risk-associated loci must be linked to cytokine genes 
A)  has been called autophagy 
B)  is prove that single genetic loci are involved 
C)  underscores the importance of microenvironmental triggers 
D)  proves that risk-associated loci must be linked to cytokine genes

Question 13

Multiple sclerosis is affected by non-genetic factors including place of birth. Risk of MS associated with birth place

Accepted Answer

A)  remains constant after relocation 
B)  changes to that typical of a new setting after relocation at any age 
C)  changes to that typical of a new setting after relocation at an early age 
D)  changes to that typical of a new setting only if relocation is sudden 
A)  remains constant after relocation 
B)  changes to that typical of a new setting after relocation at any age 
C)  changes to that typical of a new setting after relocation at an early age 
D)  changes to that typical of a new setting only if relocation is sudden

Question 14

The rate of new cancer cases per year is lowest in

Accepted Answer

A)  the United States 
B)  Western Europe 
C)  Eastern Africa 
D)  the Phillipines 
A)  the United States 
B)  Western Europe 
C)  Eastern Africa 
D)  the Phillipines

Question 15

Which of the following is true about cancer

Accepted Answer

A)  it is a dsease of modern society 
B)  it was described in ancient Chinese medical texts 
C)  it was attributed to lack of black bile 
D)  it is more prevalent in underdeveloped societies 
A)  it is a dsease of modern society 
B)  it was described in ancient Chinese medical texts 
C)  it was attributed to lack of black bile 
D)  it is more prevalent in underdeveloped societies

Question 16

HLA B27 is found in nearly 90% of individuals diagnosed with

Accepted Answer

A)  paraneoplastic syndromes 
B)  ankylosing spondylitis 
C)  rheumatoid arthritis 
D)  none of the above 
A)  paraneoplastic syndromes 
B)  ankylosing spondylitis 
C)  rheumatoid arthritis 
D)  none of the above

Question 17

The concept of cancer immunoediting refers to the fact that cancer cells

Accepted Answer

A)  evolve to counteract immune attack 
B)  are eliminated by well orchestrated immune attack 
C)  are capable of metastsis 
D)  none of the above 
A)  evolve to counteract immune attack 
B)  are eliminated by well orchestrated immune attack 
C)  are capable of metastsis 
D)  none of the above

Question 18

A recessive cancer gene also known as the guardian of the genome is

Accepted Answer

A)  p53 
B)  BRAF 
C)  JAK2 
D)  GATA3 
A)  p53 
B)  BRAF 
C)  JAK2 
D)  GATA3

Question 19

Rheumatoid arthritis has historically been linked to

Accepted Answer

A)  over expression of aggression 
B)  failure to acknowledge anger 
C)  excessive independence 
D)  both b and c 
A)  over expression of aggression 
B)  failure to acknowledge anger 
C)  excessive independence 
D)  both b and c

Question 20

Psychiatric disorders such as depression and schizophrenia

Accepted Answer

A)  are both known to decrese the risk of cancer 
B)  clearly have no effect on cancer risk 
C)  have been thought to have opposite effects on cancer risk 
D)  generally increase the risk of cancer due to stress 
A)  are both known to decrese the risk of cancer 
B)  clearly have no effect on cancer risk 
C)  have been thought to have opposite effects on cancer risk 
D)  generally increase the risk of cancer due to stress

Autoimmune activity may be unleashed as a result of infection due to

Autoimmune attack may be initiated by a failure

Which of the following is true about the impact of psychosocial factors on cancer

Which of the following is false in the case of SLE

The effect of psychosocial stress on cancer

Research on immune activity and cancer survival

Which of the following is true in the case of rheumatoid arthritis

Extraversion, a personality characteristic associated with positive affeect

Primary defense against cancer appear to be

Adverse psychosocial experiences in early life

Psychosocial stress has been found to be less clearly associated with

The observation that a self-antigen present in multiple organs may be the target of autoimmunity in only one organ

Multiple sclerosis is affected by non-genetic factors including place of birth. Risk of MS associated with birth place

The rate of new cancer cases per year is lowest in

Which of the following is true about cancer

HLA B27 is found in nearly 90% of individuals diagnosed with

The concept of cancer immunoediting refers to the fact that cancer cells

A recessive cancer gene also known as the guardian of the genome is

Rheumatoid arthritis has historically been linked to

Psychiatric disorders such as depression and schizophrenia

Introduction

Historical Antecedents

Immune System Basics

Endocrine-Immune Modulation

Neuroimmune Modulation

Stress, Contextual Change, and Disease

Psychosocial Stress

Infection, Allergy, and Psychosocial Stress

Immune Activity and Psychopathology

Immune Function Enhancement

Integration and Implications

Filters

Exam 9: Cancer, Autoimmunity, and Psychosocial Stress

Autoimmune activity may be unleashed as a result of infection due to

Autoimmune attack may be initiated by a failure

Which of the following is true about the impact of psychosocial factors on cancer

Which of the following is false in the case of SLE

The effect of psychosocial stress on cancer

Research on immune activity and cancer survival

Which of the following is true in the case of rheumatoid arthritis

Extraversion, a personality characteristic associated with positive affeect

Primary defense against cancer appear to be

Adverse psychosocial experiences in early life

Psychosocial stress has been found to be less clearly associated with

The observation that a self-antigen present in multiple organs may be the target of autoimmunity in only one organ

Multiple sclerosis is affected by non-genetic factors including place of birth. Risk of MS associated with birth place

The rate of new cancer cases per year is lowest in

Which of the following is true about cancer

HLA B27 is found in nearly 90% of individuals diagnosed with

The concept of cancer immunoediting refers to the fact that cancer cells

A recessive cancer gene also known as the guardian of the genome is

Rheumatoid arthritis has historically been linked to

Psychiatric disorders such as depression and schizophrenia

Introduction

Historical Antecedents

Immune System Basics

Endocrine-Immune Modulation

Neuroimmune Modulation

Stress, Contextual Change, and Disease

Psychosocial Stress

Infection, Allergy, and Psychosocial Stress

Immune Activity and Psychopathology

Immune Function Enhancement

Integration and Implications

Filters