Question 1

Which is a primary lymphoid organ?

Accepted Answer

A)  the spleen 
B)  tonsils 
C)  thymus 
D)  lymph nodes 
A)  the spleen 
B)  tonsils 
C)  thymus 
D)  lymph nodes

Question 2

Which of the following exhibits allelic exclusion in its expression?

Accepted Answer

A)  T-cell receptor 
B)  class I 
C)  class II 
D)  killer inhibitory receptor 
A)  T-cell receptor 
B)  class I 
C)  class II 
D)  killer inhibitory receptor

Question 3

T lymphocytes undergo antigen-independent maturation in the:

Accepted Answer

A)  thymus 
B)  bone marrow 
C)  lymph node 
D)  spleen 
A)  thymus 
B)  bone marrow 
C)  lymph node 
D)  spleen

Question 4

The difference in kinetics between a primary and secondary immune response is due to the presence of:

Accepted Answer

A)  memory cells in the secondary response 
B)  suppressor cells in the primary response 
C)  macrophages in the secondary response 
D)  T cells in the primary response 
A)  memory cells in the secondary response 
B)  suppressor cells in the primary response 
C)  macrophages in the secondary response 
D)  T cells in the primary response

Question 5

The function of T cells with CD4 antigen is which of the following?

Accepted Answer

A)  to help B cells make antibody 
B)  to kill virally infected cells 
C)  phagocytosis 
D)  production of opsonins 
A)  to help B cells make antibody 
B)  to kill virally infected cells 
C)  phagocytosis 
D)  production of opsonins

Question 6

The germinal center of a lymph node is made up primarily of which type of cell?

Accepted Answer

A)  B cells 
B)  T cells 
C)  dendritic 
D)  macrophages 
A)  B cells 
B)  T cells 
C)  dendritic 
D)  macrophages

Question 7

B cells that respond against self-antigens will undergo:

Accepted Answer

A)  receptor editing 
B)  anergy 
C)  apoptosis 
D)  all of these 
E)  two of these 
A)  receptor editing 
B)  anergy 
C)  apoptosis 
D)  all of these 
E)  two of these

Question 8

Neutrophils and other cells have receptors on their surface that bind to the Fc region of IgG,which is known as:

Accepted Answer

A)  CD3 
B)  CD4 
C)  CD8 
D)  CD16 
A)  CD3 
B)  CD4 
C)  CD8 
D)  CD16

Question 9

Cytotoxic T cells are the primary immune response against which pathogen?

Accepted Answer

A)  viruses 
B)  intracellular parasites 
C)  extracellular bacteria 
D)  intracellular bacteria 
A)  viruses 
B)  intracellular parasites 
C)  extracellular bacteria 
D)  intracellular bacteria

Question 10

Tissues that function by trapping and concentrating antigens for presentation to cells of the immune system are known as:

Accepted Answer

A)  peripheral or secondary lymphoid organs 
B)  primary or generative lymphoid organs 
C)  either of the above 
D)  neither of the above 
A)  peripheral or secondary lymphoid organs 
B)  primary or generative lymphoid organs 
C)  either of the above 
D)  neither of the above

Question 11

Antigen-independent differentiation of B cells occurs in the:

Accepted Answer

A)  bone marrow 
B)  spleen 
C)  lymph node 
D)  Peyer's patches 
A)  bone marrow 
B)  spleen 
C)  lymph node 
D)  Peyer's patches

Question 12

A plasma cell differs from a B cell in which way?

Accepted Answer

A)  Plasma cells are only found in peripheral blood. 
B)  Only plasma cells secrete circulating antibody. 
C)  Plasma cells secrete cytokines. 
D)  Plasma cells are an immature form in B-cell development. 
A)  Plasma cells are only found in peripheral blood. 
B)  Only plasma cells secrete circulating antibody. 
C)  Plasma cells secrete cytokines. 
D)  Plasma cells are an immature form in B-cell development.

Question 13

D-J rearrangements only have occurred in which stage of B cell development?

Accepted Answer

A)  pro-B cell 
B)  pre-B cell 
C)  immature B cell 
D)  mature B cell 
A)  pro-B cell 
B)  pre-B cell 
C)  immature B cell 
D)  mature B cell

Question 14

The only cells in the body capable of specifically recognizing and distinguishing different antigenic determinants are:

Accepted Answer

A)  macrophages 
B)  dendritic cells 
C)  lymphocytes 
D)  neutrophils 
A)  macrophages 
B)  dendritic cells 
C)  lymphocytes 
D)  neutrophils

Question 15

The purpose of negative selection of B cells is to:

Accepted Answer

A)  Eliminate B cells that don't express mu. 
B)  Prevent activation of B cells in the bone marrow. 
C)  Direct more B cells to become T cells. 
D)  Identify B cells that are specific for self-antigens. 
A)  Eliminate B cells that don't express mu. 
B)  Prevent activation of B cells in the bone marrow. 
C)  Direct more B cells to become T cells. 
D)  Identify B cells that are specific for self-antigens.

Question 16

Which of the following cells that participate in cell-mediated immunity are antigen specific and directly cytotoxic for target cells?

Accepted Answer

A)  macrophages 
B)  TH1 cells 
C)  cytotoxic T cells 
D)  natural killer cells 
A)  macrophages 
B)  TH1 cells 
C)  cytotoxic T cells 
D)  natural killer cells

Question 17

Which of the following would be found on the surface of a pre-B cell?

Accepted Answer

A)  delta and kappa chains 
B)  gamma and lambda chains 
C)  epsilon and kappa chains 
D)  mu and surrogate light chains 
A)  delta and kappa chains 
B)  gamma and lambda chains 
C)  epsilon and kappa chains 
D)  mu and surrogate light chains

Question 18

A T cell that is rarely found in secondary lymphoid organs and recognizes a limited number of native epitopes is known as a(n):

Accepted Answer

A)  helper T cell 
B)  gamma-delta T cell 
C)  cytotoxic T cell 
D)  alpha-beta T cell 
A)  helper T cell 
B)  gamma-delta T cell 
C)  cytotoxic T cell 
D)  alpha-beta T cell

Question 19

Granzymes activate which of the following in a target cell?

Accepted Answer

A)  phagocytosis 
B)  apoptosis 
C)  cytokine secretion 
D)  complement activation 
A)  phagocytosis 
B)  apoptosis 
C)  cytokine secretion 
D)  complement activation

Question 20

Which of the following would be considered a primary lymphoid organ?

Accepted Answer

A)  spleen 
B)  lymph nodes 
C)  tonsils 
D)  bone marrow 
A)  spleen 
B)  lymph nodes 
C)  tonsils 
D)  bone marrow

Exam 2: Lymphoid System

Which is a primary lymphoid organ?

Which of the following exhibits allelic exclusion in its expression?

T lymphocytes undergo antigen-independent maturation in the:

The difference in kinetics between a primary and secondary immune response is due to the presence of:

The function of T cells with CD4 antigen is which of the following?

The germinal center of a lymph node is made up primarily of which type of cell?

B cells that respond against self-antigens will undergo:

Neutrophils and other cells have receptors on their surface that bind to the Fc region of IgG,which is known as:

Cytotoxic T cells are the primary immune response against which pathogen?

Tissues that function by trapping and concentrating antigens for presentation to cells of the immune system are known as:

Antigen-independent differentiation of B cells occurs in the:

A plasma cell differs from a B cell in which way?

D-J rearrangements only have occurred in which stage of B cell development?

The only cells in the body capable of specifically recognizing and distinguishing different antigenic determinants are:

The purpose of negative selection of B cells is to:

Which of the following cells that participate in cell-mediated immunity are antigen specific and directly cytotoxic for target cells?

Which of the following would be found on the surface of a pre-B cell?

A T cell that is rarely found in secondary lymphoid organs and recognizes a limited number of native epitopes is known as a(n):

Granzymes activate which of the following in a target cell?

Which of the following would be considered a primary lymphoid organ?

Introduction and Natural Immunity

Nature of Antigens and Major Histocompatibility Complex

Antibody Structure and Function

Cytokines

Complement System

Safety and Specimen Preparation

Precipitation Reactions

Agglutination

Labeled Immunoassays

Molecular Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Immunoproliferative Diseases

Immunodeficiency Disease

Transplantation Immunology

Tumor Immunology

Serologic and Molecular Detection of Bacterial Infections

Serologic and Molecular Detection of Bacterial Infections

Serology of Parasitic and Fungal Infections

Spirochete Diseases

Filters