Question 1

Which of the following distinguishes mature B cells from B cells at other stages of development?

Accepted Answer

A)  co-expression of IgM and IgD 
B)  expression of surrogate light chains 
C)  lack of surface immunoglobulin 
D)  only stage to express IgA and IgB 
A)  co-expression of IgM and IgD 
B)  expression of surrogate light chains 
C)  lack of surface immunoglobulin 
D)  only stage to express IgA and IgB

Question 2

Which of the following contain B cells that are actively responding to antigen?

Accepted Answer

A)  peripheral blood 
B)  primary follicles 
C)  germinal centers 
D)  bone marrow 
A)  peripheral blood 
B)  primary follicles 
C)  germinal centers 
D)  bone marrow

Question 3

B cells that express low-affinity IgM,respond to bacterial polysaccharides,and express CD5 are known as:

Accepted Answer

A)  B-2 cells 
B)  plasma cells 
C)  B-1 cells 
D)  memory B cells 
A)  B-2 cells 
B)  plasma cells 
C)  B-1 cells 
D)  memory B cells

Question 4

The stage in B-cell development in which TdT and RAG enzymes appear is called:

Accepted Answer

A)  thymocyte 
B)  pro-B 
C)  pre-B 
D)  plasma cells 
A)  thymocyte 
B)  pro-B 
C)  pre-B 
D)  plasma cells

Question 5

When IgM on the surface of an immature B cell binds to a self-antigen,which of the following processes can occur?

Accepted Answer

A)  class switch 
B)  affinity maturation 
C)  apoptosis 
D)  differentiation 
A)  class switch 
B)  affinity maturation 
C)  apoptosis 
D)  differentiation

Question 6

Which of the following binds to CD16 on the surface of natural killer cells?

Accepted Answer

A)  class I 
B)  Fc of IgG 
C)  T-cell receptor 
D)  peptide 
A)  class I 
B)  Fc of IgG 
C)  T-cell receptor 
D)  peptide

Question 7

Lymphocytes that have IgM,IgD,and MHC class II antigens on their surface,and they mature in the bone marrow itself,are:

Accepted Answer

A)  B cells 
B)  T cells 
C)  NK cells 
D)  eosinophils 
A)  B cells 
B)  T cells 
C)  NK cells 
D)  eosinophils

Question 8

The primary site of antigen trapping and presentation to immune cells is the:

Accepted Answer

A)  spleen 
B)  thymus 
C)  bone marrow 
D)  brain 
A)  spleen 
B)  thymus 
C)  bone marrow 
D)  brain

Question 9

Immunoglobulin and T-cell receptors are similar in which of the following properties?

Accepted Answer

A)  multiple gene segments encoding the variable region 
B)  antigen-binding site that recognizes conformational epitopes 
C)  requirement for antigen presentation 
D)  antigen-dependent somatic mutation 
A)  multiple gene segments encoding the variable region 
B)  antigen-binding site that recognizes conformational epitopes 
C)  requirement for antigen presentation 
D)  antigen-dependent somatic mutation

Question 10

Which of the following surface markers are found on mature T cells?

Accepted Answer

A)  IgM and IgD 
B)  IgG and IgA 
C)  CD19 
D)  CD3 
A)  IgM and IgD 
B)  IgG and IgA 
C)  CD19 
D)  CD3

Question 11

Helper T cells function directly in:

Accepted Answer

A)  presenting antigen with class I MHC 
B)  delayed-type hypersensitivity 
C)  performing VDJ rearrangement in B cells 
D)  target cells with perforin 
A)  presenting antigen with class I MHC 
B)  delayed-type hypersensitivity 
C)  performing VDJ rearrangement in B cells 
D)  target cells with perforin

Question 12

Sheep red blood cells forming rosettes around T cells is due to the presence of which of the following on T cells?

Accepted Answer

A)  CD2 
B)  CD8 
C)  CD16 
D)  CD56 
A)  CD2 
B)  CD8 
C)  CD16 
D)  CD56

Question 13

Which of the following surface markers are found on mature B cells?

Accepted Answer

A)  IgM and IgD 
B)  IgG and IgA 
C)  CD4 
D)  CD3 
A)  IgM and IgD 
B)  IgG and IgA 
C)  CD4 
D)  CD3

Question 14

Which cell is capable of producing antibody?

Accepted Answer

A)  plasma cell 
B)  CD4+ T cell 
C)  macrophage 
D)  neutrophil 
A)  plasma cell 
B)  CD4+ T cell 
C)  macrophage 
D)  neutrophil

Question 15

Which best describes the specific antigen receptor that is a part of CD3 found on T cells?

Accepted Answer

A)  It appears in the double-negative stage. 
B)  Alpha and beta chains bind antigen. 
C)  It is found only on T helper cells. 
D)  All eight chains are specific for antigen. 
A)  It appears in the double-negative stage. 
B)  Alpha and beta chains bind antigen. 
C)  It is found only on T helper cells. 
D)  All eight chains are specific for antigen.

Question 16

How are cytotoxic T cells and natural killer cells similar?

Accepted Answer

A)  Both require antibody to be bound to the target cell. 
B)  Both induce apoptosis in the target cell. 
C)  Both recognize peptide plus HLA class I. 
D)  Both kill target cells lacking HLA class I. 
A)  Both require antibody to be bound to the target cell. 
B)  Both induce apoptosis in the target cell. 
C)  Both recognize peptide plus HLA class I. 
D)  Both kill target cells lacking HLA class I.

Question 17

Where does contact with antigen and activation of B cells normally occur?

Accepted Answer

A)  in the peripheral blood 
B)  in connective tissue 
C)  in the thymus 
D)  in lymph nodes 
A)  in the peripheral blood 
B)  in connective tissue 
C)  in the thymus 
D)  in lymph nodes

Question 18

A cell that can recall previous contact with a particular antigen so that subsequent exposure leads to a more rapid and more effective immune response than the first encounter is by definition which type of cell?

Accepted Answer

A)  memory lymphocyte 
B)  effector lymphocyte 
C)  plasma cell 
D)  stem cell 
A)  memory lymphocyte 
B)  effector lymphocyte 
C)  plasma cell 
D)  stem cell

Question 19

T helper cells recognize which of the following?

Accepted Answer

A)  exogenous peptide bound to class II 
B)  native extracellular viral proteins 
C)  endogenous peptides bound to class I 
D)  microbe-specific structures 
A)  exogenous peptide bound to class II 
B)  native extracellular viral proteins 
C)  endogenous peptides bound to class I 
D)  microbe-specific structures

Question 20

Which marker is found on the group of T cells that assist B cells in making antibody?

Accepted Answer

A)  CD2 
B)  CD19 
C)  CD4 
D)  CD5 
A)  CD2 
B)  CD19 
C)  CD4 
D)  CD5

Exam 2: Lymphoid System

Which of the following distinguishes mature B cells from B cells at other stages of development?

Which of the following contain B cells that are actively responding to antigen?

B cells that express low-affinity IgM,respond to bacterial polysaccharides,and express CD5 are known as:

The stage in B-cell development in which TdT and RAG enzymes appear is called:

When IgM on the surface of an immature B cell binds to a self-antigen,which of the following processes can occur?

Which of the following binds to CD16 on the surface of natural killer cells?

Lymphocytes that have IgM,IgD,and MHC class II antigens on their surface,and they mature in the bone marrow itself,are:

The primary site of antigen trapping and presentation to immune cells is the:

Immunoglobulin and T-cell receptors are similar in which of the following properties?

Which of the following surface markers are found on mature T cells?

Helper T cells function directly in:

Sheep red blood cells forming rosettes around T cells is due to the presence of which of the following on T cells?

Which of the following surface markers are found on mature B cells?

Which cell is capable of producing antibody?

Which best describes the specific antigen receptor that is a part of CD3 found on T cells?

How are cytotoxic T cells and natural killer cells similar?

Where does contact with antigen and activation of B cells normally occur?

A cell that can recall previous contact with a particular antigen so that subsequent exposure leads to a more rapid and more effective immune response than the first encounter is by definition which type of cell?

T helper cells recognize which of the following?

Which marker is found on the group of T cells that assist B cells in making antibody?

Introduction and Natural Immunity

Nature of Antigens and Major Histocompatibility Complex

Antibody Structure and Function

Cytokines

Complement System

Safety and Specimen Preparation

Precipitation Reactions

Agglutination

Labeled Immunoassays

Molecular Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Immunoproliferative Diseases

Immunodeficiency Disease

Transplantation Immunology

Tumor Immunology

Serologic and Molecular Detection of Bacterial Infections

Serologic and Molecular Detection of Bacterial Infections

Serology of Parasitic and Fungal Infections

Spirochete Diseases

Filters