Question 1

T cells emerging from the thymus are:

Accepted Answer

A)  MHC restricted 
B)  self-tolerant 
C)  antigen specific 
D)  all of these 
A)  MHC restricted 
B)  self-tolerant 
C)  antigen specific 
D)  all of these D

Question 2

The cells that primarily function by secreting large amounts of cytokines are:

Accepted Answer

A)  plasma cells 
B)  B cells 
C)  T helper cells 
D)  cytotoxic T cells 
A)  plasma cells 
B)  B cells 
C)  T helper cells 
D)  cytotoxic T cells C

Question 3

T cells travel from the bone marrow to the thymus for maturation.What is the correct order of the maturation sequence for T cells in the thymus?

Accepted Answer

A)  bone marrow to the cortex; after thymic education,released back to peripheral circulation 
B)  storage in either the cortex or medulla; release of T cells into the peripheral circulation 
C)  maturation and selection occur in the cortex,then the medulla; release of mature T cells to secondary lymphoid organs 
D)  activation and selection occur in the medulla; mature T cells stored in the cortex until activated by antigen 
A)  bone marrow to the cortex; after thymic education,released back to peripheral circulation 
B)  storage in either the cortex or medulla; release of T cells into the peripheral circulation 
C)  maturation and selection occur in the cortex,then the medulla; release of mature T cells to secondary lymphoid organs 
D)  activation and selection occur in the medulla; mature T cells stored in the cortex until activated by antigen C

Question 4

The receptor for antigen on a mature naïve B cell is:

Accepted Answer

A)  MHC class I 
B)  IgG 
C)  IgM 
D)  MHC class II 
A)  MHC class I 
B)  IgG 
C)  IgM 
D)  MHC class II

Question 5

Predominant cell types involved in the humoral immune response are:

Accepted Answer

A)  eosinophils 
B)  macrophages 
C)  neutrophils 
D)  B cells 
A)  eosinophils 
B)  macrophages 
C)  neutrophils 
D)  B cells

Question 6

Which marker would be found on pre-B cells?

Accepted Answer

A)  CD3 
B)  ($\mu$) heavy chains 
C)  CD16 
D)  IgD 
A)  CD3 
B)  ($\mu$) heavy chains 
C)  CD16 
D)  IgD

Question 7

Lymphocytes that mature in the thymus are involved in which immune response?

Accepted Answer

A)  cytokine-mediated responses 
B)  antibody production 
C)  phagocytosis 
D)  any of the above 
A)  cytokine-mediated responses 
B)  antibody production 
C)  phagocytosis 
D)  any of the above

Question 8

In antibody-dependent cell-mediated cytotoxicity,target cells are recognized by which of the following?

Accepted Answer

A)  T-cell receptor on the effector cell binding to Fab of IgG bound to the target cell 
B)  C-type lectin inhibitory receptors on effector cell binding to class I on target cell 
C)  CD16 on the effector cell binding to Fc of IgG bound to the target cell 
D)  CD154 on the effector cell binding to CD40 on the target cell 
A)  T-cell receptor on the effector cell binding to Fab of IgG bound to the target cell 
B)  C-type lectin inhibitory receptors on effector cell binding to class I on target cell 
C)  CD16 on the effector cell binding to Fc of IgG bound to the target cell 
D)  CD154 on the effector cell binding to CD40 on the target cell

Question 9

The T-cell receptor for antigen comprises which of the following molecules?

Accepted Answer

A)  alpha and betachains 
B)  two gamma and two delta chains 
C)  epsilon and gamma chains 
D)  alpha chain and beta-2-microglobulin 
A)  alpha and betachains 
B)  two gamma and two delta chains 
C)  epsilon and gamma chains 
D)  alpha chain and beta-2-microglobulin

Question 10

All of the following are characteristic of a lymph node EXCEPT:

Accepted Answer

A)  filters drainage from tissues 
B)  colonized with T and B cells 
C)  between 1 and 25 mm in size 
D)  considered a primary or central lymphoid organ 
A)  filters drainage from tissues 
B)  colonized with T and B cells 
C)  between 1 and 25 mm in size 
D)  considered a primary or central lymphoid organ

Question 11

Which of the following is a cytotoxic T cell membrane-bound factor that is involved in inducing apoptosis in target cells?

Accepted Answer

A)  perforin 
B)  IL-2 
C)  granzyme 
D)  Fas ligand 
A)  perforin 
B)  IL-2 
C)  granzyme 
D)  Fas ligand

Question 12

Which of the following would NOT be found on the surface of a mature,naive B cell?

Accepted Answer

A)  IgA and IgB 
B)  lambda and mu chains 
C)  CD19 
D)  surrogate light chains 
A)  IgA and IgB 
B)  lambda and mu chains 
C)  CD19 
D)  surrogate light chains

Question 13

A lymphocyte exhibits the following markers: CD19,IgM,IgD.What is its likely identity?

Accepted Answer

A)  double-negative T cell 
B)  immature B cell 
C)  double-positive T cell 
D)  mature B cell 
A)  double-negative T cell 
B)  immature B cell 
C)  double-positive T cell 
D)  mature B cell

Question 14

An immature T cell differs from a mature T cell because an immature T cell:

Accepted Answer

A)  expresses beta chains and pre-Ta 
B)  does not express T-cell receptor or CD3 
C)  co-expresses CD4 and CD8 
D)  is normally found in lymph nodes 
A)  expresses beta chains and pre-Ta 
B)  does not express T-cell receptor or CD3 
C)  co-expresses CD4 and CD8 
D)  is normally found in lymph nodes

Question 15

All lymphocytes arise from stem cells made in the:

Accepted Answer

A)  bone marrow 
B)  spleen 
C)  lymph nodes 
D)  liver 
A)  bone marrow 
B)  spleen 
C)  lymph nodes 
D)  liver

Question 16

Perforin and granzymes are used by which cells to kill target cells?

Accepted Answer

A)  CD8 T cells 
B)  CD4 T cells 
C)  natural killer cells 
D)  B cells 
E)  two of these 
A)  CD8 T cells 
B)  CD4 T cells 
C)  natural killer cells 
D)  B cells 
E)  two of these

Question 17

Which of the following represents the best explanation for the action of natural killer (NK)cells?

Accepted Answer

A)  They recognize specific antigen. 
B)  They kill if MHC class I is present. 
C)  They kill by releasing perforins. 
D)  They participate in phagocytosis. 
A)  They recognize specific antigen. 
B)  They kill if MHC class I is present. 
C)  They kill by releasing perforins. 
D)  They participate in phagocytosis.

Question 18

Which cells are responsible for killing virally infected host cells and tumor cells?

Accepted Answer

A)  CD4 T cells 
B)  CD8 T cells 
C)  B cells 
D)  eosinophils 
A)  CD4 T cells 
B)  CD8 T cells 
C)  B cells 
D)  eosinophils

Question 19

The purpose or end result of negative selection of the T cell is to ensure:

Accepted Answer

A)  MHC restriction 
B)  self-tolerance 
C)  T-cell receptor expression 
D)  expression of CD3 
A)  MHC restriction 
B)  self-tolerance 
C)  T-cell receptor expression 
D)  expression of CD3

Question 20

T cells differ from B cells in which of the following ways?

Accepted Answer

A)  T cells express surface immunoglobulin. 
B)  B cells express CD19 but not CD3. 
C)  T cells express CD19,CD3,and CD4. 
D)  B cells express surface immunoglobulin and CD3. 
A)  T cells express surface immunoglobulin. 
B)  B cells express CD19 but not CD3. 
C)  T cells express CD19,CD3,and CD4. 
D)  B cells express surface immunoglobulin and CD3.

Exam 2: Lymphoid System

T cells emerging from the thymus are:

The cells that primarily function by secreting large amounts of cytokines are:

T cells travel from the bone marrow to the thymus for maturation.What is the correct order of the maturation sequence for T cells in the thymus?

The receptor for antigen on a mature naïve B cell is:

Predominant cell types involved in the humoral immune response are:

Which marker would be found on pre-B cells?

Lymphocytes that mature in the thymus are involved in which immune response?

In antibody-dependent cell-mediated cytotoxicity,target cells are recognized by which of the following?

The T-cell receptor for antigen comprises which of the following molecules?

All of the following are characteristic of a lymph node EXCEPT:

Which of the following is a cytotoxic T cell membrane-bound factor that is involved in inducing apoptosis in target cells?

Which of the following would NOT be found on the surface of a mature,naive B cell?

A lymphocyte exhibits the following markers: CD19,IgM,IgD.What is its likely identity?

An immature T cell differs from a mature T cell because an immature T cell:

All lymphocytes arise from stem cells made in the:

Perforin and granzymes are used by which cells to kill target cells?

Which of the following represents the best explanation for the action of natural killer (NK)cells?

Which cells are responsible for killing virally infected host cells and tumor cells?

The purpose or end result of negative selection of the T cell is to ensure:

T cells differ from B cells in which of the following ways?

Introduction and Natural Immunity

Nature of Antigens and Major Histocompatibility Complex

Antibody Structure and Function

Cytokines

Complement System

Safety and Specimen Preparation

Precipitation Reactions

Agglutination

Labeled Immunoassays

Molecular Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Immunoproliferative Diseases

Immunodeficiency Disease

Transplantation Immunology

Tumor Immunology

Serologic and Molecular Detection of Bacterial Infections

Serologic and Molecular Detection of Bacterial Infections

Serology of Parasitic and Fungal Infections

Spirochete Diseases

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