Question 1

The antibody found on B cells that is thought to be involved in B-cell maturation is:

Accepted Answer

A)  IgA. 
B)  IgD. 
C)  IgE. 
D)  IgM. 
A)  IgA. 
B)  IgD. 
C)  IgE. 
D)  IgM.

Question 2

The idiotype of an antibody is located on which region?

Accepted Answer

A)  CH 
B)  CL 
C)  VH + VL 
D)  Fc 
A)  CH 
B)  CL 
C)  VH + VL 
D)  Fc

Question 3

Somatic mutation of immunoglobulin genes accounts for:

Accepted Answer

A)  allelic exclusion. 
B)  class switching from IgM to IgG. 
C)  affinity maturation. 
D)  creation of the isotype. 
A)  allelic exclusion. 
B)  class switching from IgM to IgG. 
C)  affinity maturation. 
D)  creation of the isotype.

Question 4

The receptor for antigen on a mature B cell is:

Accepted Answer

A)  MHC class I. 
B)  IgG. 
C)  IgM. 
D)  MHC class II. 
A)  MHC class I. 
B)  IgG. 
C)  IgM. 
D)  MHC class II.

Question 5

Which immunoglobulin appears first in the primary response?

Accepted Answer

A)  IgG 
B)  IgM 
C)  IgA 
D)  IgE 
A)  IgG 
B)  IgM 
C)  IgA 
D)  IgE

Question 6

Which of the following is a characteristic of IgA?

Accepted Answer

A)  It is found in secretions. 
B)  It fixes complement. 
C)  It is a pentamer in serum. 
D)  It is the primary response antibody. 
A)  It is found in secretions. 
B)  It fixes complement. 
C)  It is a pentamer in serum. 
D)  It is the primary response antibody.

Question 7

IgD is produced by:

Accepted Answer

A)  differential splicing of the RNA transcript. 
B)  differential splicing of the DNA transcript. 
C)  constant gene-region rearrangement. 
D)  immature B cells. 
A)  differential splicing of the RNA transcript. 
B)  differential splicing of the DNA transcript. 
C)  constant gene-region rearrangement. 
D)  immature B cells.

Question 8

A Fab fragment consists of:

Accepted Answer

A)  two heavy chains. 
B)  two light chains. 
C)  one light chain and one-half of a heavy chain. 
D)  one light chain and an entire heavy chain. 
A)  two heavy chains. 
B)  two light chains. 
C)  one light chain and one-half of a heavy chain. 
D)  one light chain and an entire heavy chain.

Question 9

Which of the following best characterizes IgD?

Accepted Answer

A)  Primary response antibody 
B)  Surface receptor for antigen 
C)  Responsible for allergic reactions 
D)  Fixes complement 
A)  Primary response antibody 
B)  Surface receptor for antigen 
C)  Responsible for allergic reactions 
D)  Fixes complement

Question 10

All polymeric but not monomeric immunoglobulins are characterized by:

Accepted Answer

A)  a secretory component. 
B)  an extra H-chain domain. 
C)  a J chain. 
D)  high carbohydrate content. 
A)  a secretory component. 
B)  an extra H-chain domain. 
C)  a J chain. 
D)  high carbohydrate content.

Question 11

The region of an antibody molecule that exhibits the greatest variability from antibody to antibody is known as the:

Accepted Answer

A)  hypervariable region. 
B)  constant region. 
C)  Fc region. 
A)  hypervariable region. 
B)  constant region. 
C)  Fc region.

Question 12

How does IgG differ from IgM?

Accepted Answer

A)  IgM can cross the placenta. 
B)  IgG can bind more antigens than IgM. 
C)  IgG is the main antibody in serum. 
D)  Only IgM has kappa light chains. 
A)  IgM can cross the placenta. 
B)  IgG can bind more antigens than IgM. 
C)  IgG is the main antibody in serum. 
D)  Only IgM has kappa light chains.

Question 13

Which of the following statements about coding for antibody molecules is true?

Accepted Answer

A)  Heavy chains are coded for on chromosome 2. 
B)  V, D, and J code for heavy chain variable regions. 
C)  DNA molecules coding for light chains are rearranged first. 
D)  V and D code for light chain variable regions. 
A)  Heavy chains are coded for on chromosome 2. 
B)  V, D, and J code for heavy chain variable regions. 
C)  DNA molecules coding for light chains are rearranged first. 
D)  V and D code for light chain variable regions.

The antibody found on B cells that is thought to be involved in B-cell maturation is:

The idiotype of an antibody is located on which region?

Somatic mutation of immunoglobulin genes accounts for:

The receptor for antigen on a mature B cell is:

Which immunoglobulin appears first in the primary response?

Which of the following is a characteristic of IgA?

IgD is produced by:

A Fab fragment consists of:

Which of the following best characterizes IgD?

All polymeric but not monomeric immunoglobulins are characterized by:

The region of an antibody molecule that exhibits the greatest variability from antibody to antibody is known as the:

How does IgG differ from IgM?

Which of the following statements about coding for antibody molecules is true?

Introduction to Immunity and the Immune System

Nature of Antigens and the Major Histocompatibility Complex

Innate Immunity

Adaptive Immunity

Cytokines

Complement System

Safety and Quality Management

Principles of Serological Testing

Precipitation and Agglutination Reactions

Labeled Immunoassays

Molecular Diagnostic Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Transplantation Immunology

Tumor Immunology

Immunoproliferative Diseases

Immunodeficiency Diseases

Serological and Molecular Detection of Bacterial Infections

Spirochete Diseases

Serological and Molecular Diagnosis of Parasitic and Fungal Infections

Serology and Molecular Detection of Viral Infections

Laboratory Diagnosis of HIV Infection

Immunization and Vaccines

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Exam 5: Antibody Structure and Function

The antibody found on B cells that is thought to be involved in B-cell maturation is:

The idiotype of an antibody is located on which region?

Somatic mutation of immunoglobulin genes accounts for:

The receptor for antigen on a mature B cell is:

Which immunoglobulin appears first in the primary response?

Which of the following is a characteristic of IgA?

IgD is produced by:

A Fab fragment consists of:

Which of the following best characterizes IgD?

All polymeric but not monomeric immunoglobulins are characterized by:

The region of an antibody molecule that exhibits the greatest variability from antibody to antibody is known as the:

How does IgG differ from IgM?

Which of the following statements about coding for antibody molecules is true?

Introduction to Immunity and the Immune System

Nature of Antigens and the Major Histocompatibility Complex

Innate Immunity

Adaptive Immunity

Cytokines

Complement System

Safety and Quality Management

Principles of Serological Testing

Precipitation and Agglutination Reactions

Labeled Immunoassays

Molecular Diagnostic Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Transplantation Immunology

Tumor Immunology

Immunoproliferative Diseases

Immunodeficiency Diseases

Serological and Molecular Detection of Bacterial Infections

Spirochete Diseases

Serological and Molecular Diagnosis of Parasitic and Fungal Infections

Serology and Molecular Detection of Viral Infections

Laboratory Diagnosis of HIV Infection

Immunization and Vaccines

Filters