Question 1

Which immunoglobulin appears in the highest titer in the secondary response?

Accepted Answer

A)  IgG 
B)  IgA 
C)  IgM 
D)  IgD 
A)  IgG 
B)  IgA 
C)  IgM 
D)  IgD

Question 2

Which immunoglobulin activates the classical complement pathway?

Accepted Answer

A)  IgD 
B)  IgM 
C)  IgA 
D)  IgE 
A)  IgD 
B)  IgM 
C)  IgA 
D)  IgE

Question 3

Of all IgG subclasses,IgG3 has the largest hinge region,making it:

Accepted Answer

A)  the only subclass capable of crossing the placenta. 
B)  the subclass with the highest number of antigen binding sites. 
C)  the most efficient subclass for activating complement. 
D)  incapable of opsonization. 
A)  the only subclass capable of crossing the placenta. 
B)  the subclass with the highest number of antigen binding sites. 
C)  the most efficient subclass for activating complement. 
D)  incapable of opsonization.

Question 4

Immunoglobulins are grouped into classes on the basis of similarities in:

Accepted Answer

A)  light chains. 
B)  heavy chains. 
C)  antigen binding sites. 
D)  disulfide bonds. 
A)  light chains. 
B)  heavy chains. 
C)  antigen binding sites. 
D)  disulfide bonds.

Question 5

Identify the correct pairing of an immunoglobulin and its property.

Accepted Answer

A)  IgA: crosses the placenta 
B)  IgG: most abundant in serum 
C)  IgM: immunoglobulin produced by a T cell 
D)  IgE: major immunoglobulin of secondary response 
A)  IgA: crosses the placenta 
B)  IgG: most abundant in serum 
C)  IgM: immunoglobulin produced by a T cell 
D)  IgE: major immunoglobulin of secondary response

Question 6

What products are the result of papain being used to cleave antibody molecules?

Accepted Answer

A)  Two Fab fragments and one Fc portion 
B)  Two L chains and two H chains 
C)  VL, CL, VH, and CH 
D)  One F(ab)2 and Fc' portions 
A)  Two Fab fragments and one Fc portion 
B)  Two L chains and two H chains 
C)  VL, CL, VH, and CH 
D)  One F(ab)2 and Fc' portions

Question 7

Select the statement about secondary response to an antigen that is true.

Accepted Answer

A)  Equal amounts of IgM and IgG are made. 
B)  IgG is increased 100-fold to 1,000-fold. 
C)  IgM is increased 100-fold. 
D)  The lag time is the same as the primary response. 
A)  Equal amounts of IgM and IgG are made. 
B)  IgG is increased 100-fold to 1,000-fold. 
C)  IgM is increased 100-fold. 
D)  The lag time is the same as the primary response.

Question 8

Immunoglobulins IgG,IgM,IgA,and IgD represent:

Accepted Answer

A)  isotypes. 
B)  allotypes. 
C)  idiotypes. 
D)  heterotypes. 
A)  isotypes. 
B)  allotypes. 
C)  idiotypes. 
D)  heterotypes.

Question 9

The ability of an antibody to opsonize is located in which region?

Accepted Answer

A)  F(ab)2 
B)  Fc 
C)  VL + VC 
D)  Hypervariable 
A)  F(ab)2 
B)  Fc 
C)  VL + VC 
D)  Hypervariable

Question 10

Variations in immunoglobulin structure that occur because of the use of different constant region domains are known as:

Accepted Answer

A)  allotypes. 
B)  idiotypes. 
C)  isotypes. 
D)  autotypes. 
A)  allotypes. 
B)  idiotypes. 
C)  isotypes. 
D)  autotypes.

Question 11

Identify the characteristic that best describes IgE.

Accepted Answer

A)  Fixes complement 
B)  Binds to mast cells 
C)  Found on mucosal surfaces 
D)  Participates in agglutination reactions 
A)  Fixes complement 
B)  Binds to mast cells 
C)  Found on mucosal surfaces 
D)  Participates in agglutination reactions

Question 12

The primary response is characterized by:

Accepted Answer

A)  the recognition of antigens by naïve B cells. 
B)  the recognition of antigens by memory B cells. 
C)  the production of large amounts of IgG. 
D)  a very short lag period. 
E)  a long duration of high titer. 
A)  the recognition of antigens by naïve B cells. 
B)  the recognition of antigens by memory B cells. 
C)  the production of large amounts of IgG. 
D)  a very short lag period. 
E)  a long duration of high titer.

Question 13

Which region of the immunoglobulin molecule can bind antigen?

Accepted Answer

A)  Fab 
B)  CL 
C)  CH 
D)  Hinge region 
A)  Fab 
B)  CL 
C)  CH 
D)  Hinge region

Question 14

Which immunoglobulin causes allergic reactions as a result of release of histamine from mast cells?

Accepted Answer

A)  IgA 
B)  IgE 
C)  IgD 
D)  IgM 
A)  IgA 
B)  IgE 
C)  IgD 
D)  IgM

Question 15

Which antibody is found mainly as a dimer in mucosal secretions?

Accepted Answer

A)  IgA 
B)  IgD 
C)  IgE 
D)  IgG 
A)  IgA 
B)  IgD 
C)  IgE 
D)  IgG

Question 16

IgG subclasses differ from one another in the number and position of:

Accepted Answer

A)  heavy chain domains. 
B)  antigen binding sites. 
C)  light chains. 
D)  disulfide bonds. 
A)  heavy chain domains. 
B)  antigen binding sites. 
C)  light chains. 
D)  disulfide bonds.

Question 17

IgA in secretions has a valence of:

Accepted Answer

A)  1. 
B)  2. 
C)  4. 
D)  10. 
A)  1. 
B)  2. 
C)  4. 
D)  10.

Question 18

Identify the true statement about the anamnestic response versus the primary response.

Accepted Answer

A)  The primary response has a long lag phase; the anamnestic response has a short lag phase. 
B)  The primary response has a short lag phase; the anamnestic response has a long lag phase. 
C)  the primary response involves a rapid increase in antibody titer, whereas the anamnestic response involves a rapid decrease in antibody titer. 
D)  The primary response involves predominantly an increase in IgG antibodies, whereas the anamnestic response involves predominantly an increase in IgM antibodies. 
A)  The primary response has a long lag phase; the anamnestic response has a short lag phase. 
B)  The primary response has a short lag phase; the anamnestic response has a long lag phase. 
C)  the primary response involves a rapid increase in antibody titer, whereas the anamnestic response involves a rapid decrease in antibody titer. 
D)  The primary response involves predominantly an increase in IgG antibodies, whereas the anamnestic response involves predominantly an increase in IgM antibodies.

Question 19

Which is characteristic of IgG?

Accepted Answer

A)  First class of antibody to appear 
B)  Found mainly in secretions 
C)  The least abundant antibody in serum 
D)  Provides immunity for the newborn 
A)  First class of antibody to appear 
B)  Found mainly in secretions 
C)  The least abundant antibody in serum 
D)  Provides immunity for the newborn

Question 20

Bence-Jones proteins are identical to:

Accepted Answer

A)  secretory IgA. 
B)  heavy chains. 
C)  light chains. 
D)  IgG molecules. 
A)  secretory IgA. 
B)  heavy chains. 
C)  light chains. 
D)  IgG molecules.

Exam 5: Antibody Structure and Function

Which immunoglobulin appears in the highest titer in the secondary response?

Which immunoglobulin activates the classical complement pathway?

Of all IgG subclasses,IgG3 has the largest hinge region,making it:

Immunoglobulins are grouped into classes on the basis of similarities in:

Identify the correct pairing of an immunoglobulin and its property.

What products are the result of papain being used to cleave antibody molecules?

Select the statement about secondary response to an antigen that is true.

Immunoglobulins IgG,IgM,IgA,and IgD represent:

The ability of an antibody to opsonize is located in which region?

Variations in immunoglobulin structure that occur because of the use of different constant region domains are known as:

Identify the characteristic that best describes IgE.

The primary response is characterized by:

Which region of the immunoglobulin molecule can bind antigen?

Which immunoglobulin causes allergic reactions as a result of release of histamine from mast cells?

Which antibody is found mainly as a dimer in mucosal secretions?

IgG subclasses differ from one another in the number and position of:

IgA in secretions has a valence of:

Identify the true statement about the anamnestic response versus the primary response.

Which is characteristic of IgG?

Bence-Jones proteins are identical to:

Introduction to Immunity and the Immune System

Nature of Antigens and the Major Histocompatibility Complex

Innate Immunity

Adaptive Immunity

Cytokines

Complement System

Safety and Quality Management

Principles of Serological Testing

Precipitation and Agglutination Reactions

Labeled Immunoassays

Molecular Diagnostic Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Transplantation Immunology

Tumor Immunology

Immunoproliferative Diseases

Immunodeficiency Diseases

Serological and Molecular Detection of Bacterial Infections

Spirochete Diseases

Serological and Molecular Diagnosis of Parasitic and Fungal Infections

Serology and Molecular Detection of Viral Infections

Laboratory Diagnosis of HIV Infection

Immunization and Vaccines

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