Question 1

Which of the following is NOT commonly conjugated to a xenobiotic?

Accepted Answer

A)  glucuronic acid 
B)  sulfate group 
C)  glutathione 
D)  salicylic acid 
E)  None of the answers is correct. 
A)  glucuronic acid 
B)  sulfate group 
C)  glutathione 
D)  salicylic acid 
E)  None of the answers is correct.

Question 2

Who is credited with the discovery of penicillin?

Accepted Answer

A)  Louis Pasteur 
B)  Alexander Fleming 
C)  Selman Waksman 
D)  Paul Ehrlich 
E)  Gerhard Domagk 
A)  Louis Pasteur 
B)  Alexander Fleming 
C)  Selman Waksman 
D)  Paul Ehrlich 
E)  Gerhard Domagk

Question 3

Which of the following is correct concerning the dissociation constant,Kd,of a drug X?

Accepted Answer

A)  A larger Kd implies tighter target to drug binding. 
B)  The Kd corresponds to the concentration of drug that binds to 90% of the target. 
C)  The Kd can be determined from the simple saturation curve of a binding reaction. 
D)  The apparent Kd increases as the KM of the true substrate increases. 
E)  None of the answers is correct. 
A)  A larger Kd implies tighter target to drug binding. 
B)  The Kd corresponds to the concentration of drug that binds to 90% of the target. 
C)  The Kd can be determined from the simple saturation curve of a binding reaction. 
D)  The apparent Kd increases as the KM of the true substrate increases. 
E)  None of the answers is correct.

Question 4

The most notable structural feature of penicillin is a four-membered ring referred to as a ______________ ring.

Accepted Answer

The answer of The most notable structural feature of penicillin...

Question 5

What concentration of a drug gives 90% of the maximum response?

Accepted Answer

A)  DC90 
B)  EC90 
C)  LC90 
D)  MC90 
E)  RC90 
A)  DC90 
B)  EC90 
C)  LC90 
D)  MC90 
E)  RC90

Question 6

Penicillin inhibits the action of the ____________________ (type of enzyme)that catalyzes the formation of cross-links in bacterial cell walls.

Accepted Answer

The answer of Penicillin inhibits the action of the ____________________...

Question 7

What method,employed in combinatorial chemistry,begins by dividing the starting scaffold into a number of sets?

Accepted Answer

A)  rational drug design 
B)  solid phase synthesis 
C)  split pool synthesis 
D)  high-throughput screening 
E)  None of the answers is correct. 
A)  rational drug design 
B)  solid phase synthesis 
C)  split pool synthesis 
D)  high-throughput screening 
E)  None of the answers is correct.

Question 8

Cyclooxygenase 2 is expressed primarily as part of the inflammatory response,whereas cyclooxygenase 1 is expressed more generally.Celecoxib (Celebrex)was designed to target COX2 and is used to reduce inflammation due to arthritis.What structural feature of Celecoxib (Celebrex)makes this drug more selective for COX2 instead of COX1?

Accepted Answer

X-ray crystallography of COX2 revealed a

Exam 36: Drug Development

Which of the following is NOT commonly conjugated to a xenobiotic?

Who is credited with the discovery of penicillin?

Which of the following is correct concerning the dissociation constant,Kd,of a drug X?

The most notable structural feature of penicillin is a four-membered ring referred to as a ______________ ring.

What concentration of a drug gives 90% of the maximum response?

Penicillin inhibits the action of the ____________________ (type of enzyme)that catalyzes the formation of cross-links in bacterial cell walls.

What method,employed in combinatorial chemistry,begins by dividing the starting scaffold into a number of sets?

Biochemistry: An Evolving Science

Protein Composition and Structure

Exploring Proteins and Proteomes

DNA, RNA, and the Flow of Genetic Information

Exploring Genes and Genomes

Exploring Evolution and Bioinformatics

Hemoglobin: a Portrait of a Protein in Action

Enzymes: Basic Concepts and Kinetics

Catalytic Strategies

Regulatory Strategies

Carbohydrates

Lipids and Cell Membranes

Membrane Channels and Pumps

Signal-Transduction Pathways

Metabolism: Basic Concepts and Design

Glycolysis and Gluconeogenesis

The Citric Acid Cycle

Oxidative Phosphorylation

The Light Reactions of Photosynthesis

The Calvin Cycle and the Pentose Phosphate Pathway

Glycogen Metabolism

Fatty Acid Metabolism

Protein Turnover and Amino Acid Catabolism

The Biosynthesis of Amino Acids

Nucleotide Biosynthesis

Biosynthesis of Membrane Lipids and Steroids

The Integration of Metabolism

DNA Replication, repair, and Recombination

RNA Synthesis and Processing

Protein Synthesis

The Control of Gene Expression in Prokaryotes

The Control of Gene Expression in Eukaryotes

Sensory Systems

The Immune System

Molecular Motors

Filters

Which of the following is correct concerning the dissociation constant,K_d,of a drug X?