Question 1

If you do a Google search for Lipinski's rules,you will observe that this predictor of bioavailability is also referred to as the "Rule of 5." Explain.

Accepted Answer

Each of the rules has a value of 5 or mu

Question 2

A drug's concentration at its target site is affected by its ADME,which is an acronym that stands for _________________________________.

Accepted Answer

absorption

Question 3

Describe how certain bacteria can development resistance to penicillin.

Accepted Answer

Some bacteria are resistant to penicilli

Question 4

What set of "rules" gives a general indication of the bioavailability of a drug?

Accepted Answer

A)  Lipovec 
B)  Lipper 
C)  Lippincott 
D)  Lipinski 
E)  Lipkowicz 
A)  Lipovec 
B)  Lipper 
C)  Lippincott 
D)  Lipinski 
E)  Lipkowicz

Question 5

Give a chemical equation for the general reaction that is catalyzed by cytochrome P450 in the metabolism of a drug.Show the functional group that is added to the molecule.

Accepted Answer

The answer of Give a chemical equation for the general...

Question 6

__________________ is an abundant protein that binds to and transports drugs everywhere the bloodstream flows.

Accepted Answer

Serum albu

Question 7

The current cost of developing a new drug is ____________ .

Accepted Answer

more than

Question 8

Briefly describe the factors that will determine the concentration of a drug at the target site in the body.

Accepted Answer

This answer is related to The drug's eff

Question 9

Which of the following properties affects the effective concentration of a drug at the target site?

Accepted Answer

A)  the rate of absorption of the drug 
B)  the extent of distribution or compartmentalization of the drug 
C)  the efficiency of metabolism of the drug 
D)  the ease of excretion of the drug and/or its metabolites 
E)  All of the answers are correct. 
A)  the rate of absorption of the drug 
B)  the extent of distribution or compartmentalization of the drug 
C)  the efficiency of metabolism of the drug 
D)  the ease of excretion of the drug and/or its metabolites 
E)  All of the answers are correct.

Question 10

Which of the following drugs were developed as a result of information obtained from a mouse model that had the gene that normally produces the α-subunit of the H+,K+ ATPase transport system "knocked out"?

Accepted Answer

A)  Prilosec and Prevacid 
B)  Celebrex and Viox 
C)  Crixivan 
D)  Lipitor and Crestor 
E)  Viagra 
A)  Prilosec and Prevacid 
B)  Celebrex and Viox 
C)  Crixivan 
D)  Lipitor and Crestor 
E)  Viagra

Question 11

What term describes a molecule that binds to a target molecule?

Accepted Answer

A)  substrate 
B)  effector 
C)  ligand 
D)  cosubstrate 
E)  None of the answers is correct. 
A)  substrate 
B)  effector 
C)  ligand 
D)  cosubstrate 
E)  None of the answers is correct.

Question 12

Sketch the binding curve for the titration of a receptor R with a ligand L,and label the point on the plot that corresponds to the Kd for the RL complex.

Accepted Answer

The answer

Question 13

Briefly describe split-pool synthesis

Accepted Answer

Combinatorial chemistry uses split-pool

Question 14

Give the reaction by which a glucuronate group (pH 7)is conjugated to a metabolite,and briefly explain the advantage of this metabolic process.

Accepted Answer

@#IMG-DLM& At pH 7,glucuronate adds a ne

Question 15

Why do some drug treatments become ineffective over time?

Accepted Answer

Infectious diseases and cancer have a co

Question 16

Which of the following is NOT one of the factors that predicts the bioavailability of a drug?

Accepted Answer

A)  The molecular weight is less than 500. 
B)  The number of hydrogen-bond donors is less than 5. 
C)  The number of hydrogen-bond acceptors is less than 10. 
D)  The partition coefficient is less than 5. 
E)  The structure contains at least two aromatic rings. 
A)  The molecular weight is less than 500. 
B)  The number of hydrogen-bond donors is less than 5. 
C)  The number of hydrogen-bond acceptors is less than 10. 
D)  The partition coefficient is less than 5. 
E)  The structure contains at least two aromatic rings.

Question 17

Which of the following is conjugated to drugs to aid excretion?

Accepted Answer

A)  glucuronic acid 
B)  cholic acid 
C)  glutamic acid 
D)  ascorbic acid 
E)  None of the answers is correct. 
A)  glucuronic acid 
B)  cholic acid 
C)  glutamic acid 
D)  ascorbic acid 
E)  None of the answers is correct.

Question 18

Give an example of how a drug was discovered by a chance observation.

Accepted Answer

1.Alexander Fleming observed that coloni

Question 19

Drug candidateIC50(nmol)Log (P)Cmax (µM)BioavailabilityA0.44.67<0.1B0.013.70<0.1C0.33.690.7D0.62.9211Consider the information concerning a related class of potential drugs in the table above.Which one would be the best candidate for further testing?

Accepted Answer

A)  A 
B)  B 
C)  C 
D)  D 
E)  None of the answers are suitable. 
A)  A 
B)  B 
C)  C 
D)  D 
E)  None of the answers are suitable.

Question 20

In which phase of drug development do healthy volunteers take the drug for initial safety studies?

Accepted Answer

A)  phase I trials 
B)  phase II trials 
C)  phase III trials 
D)  pre-clinical trials 
E)  None of the answers is correct. 
A)  phase I trials 
B)  phase II trials 
C)  phase III trials 
D)  pre-clinical trials 
E)  None of the answers is correct.

Exam 36: Drug Development

If you do a Google search for Lipinski's rules,you will observe that this predictor of bioavailability is also referred to as the "Rule of 5." Explain.

A drug's concentration at its target site is affected by its ADME,which is an acronym that stands for _________________________________.

Describe how certain bacteria can development resistance to penicillin.

What set of "rules" gives a general indication of the bioavailability of a drug?

Give a chemical equation for the general reaction that is catalyzed by cytochrome P450 in the metabolism of a drug.Show the functional group that is added to the molecule.

__________________ is an abundant protein that binds to and transports drugs everywhere the bloodstream flows.

The current cost of developing a new drug is ____________ .

Briefly describe the factors that will determine the concentration of a drug at the target site in the body.

Which of the following properties affects the effective concentration of a drug at the target site?

Which of the following drugs were developed as a result of information obtained from a mouse model that had the gene that normally produces the α-subunit of the H+,K+ ATPase transport system "knocked out"?

What term describes a molecule that binds to a target molecule?

Sketch the binding curve for the titration of a receptor R with a ligand L,and label the point on the plot that corresponds to the Kd for the RL complex.

Briefly describe split-pool synthesis

Give the reaction by which a glucuronate group (pH 7)is conjugated to a metabolite,and briefly explain the advantage of this metabolic process.

Why do some drug treatments become ineffective over time?

Which of the following is NOT one of the factors that predicts the bioavailability of a drug?

Which of the following is conjugated to drugs to aid excretion?

Give an example of how a drug was discovered by a chance observation.

Drug candidateIC50(nmol)Log (P)Cmax (µM)BioavailabilityA0.44.67<0.1B0.013.70<0.1C0.33.690.7D0.62.9211Consider the information concerning a related class of potential drugs in the table above.Which one would be the best candidate for further testing?

In which phase of drug development do healthy volunteers take the drug for initial safety studies?

Biochemistry: An Evolving Science

Protein Composition and Structure

Exploring Proteins and Proteomes

DNA, RNA, and the Flow of Genetic Information

Exploring Genes and Genomes

Exploring Evolution and Bioinformatics

Hemoglobin: a Portrait of a Protein in Action

Enzymes: Basic Concepts and Kinetics

Catalytic Strategies

Regulatory Strategies

Carbohydrates

Lipids and Cell Membranes

Membrane Channels and Pumps

Signal-Transduction Pathways

Metabolism: Basic Concepts and Design

Glycolysis and Gluconeogenesis

The Citric Acid Cycle

Oxidative Phosphorylation

The Light Reactions of Photosynthesis

The Calvin Cycle and the Pentose Phosphate Pathway

Glycogen Metabolism

Fatty Acid Metabolism

Protein Turnover and Amino Acid Catabolism

The Biosynthesis of Amino Acids

Nucleotide Biosynthesis

Biosynthesis of Membrane Lipids and Steroids

The Integration of Metabolism

DNA Replication, repair, and Recombination

RNA Synthesis and Processing

Protein Synthesis

The Control of Gene Expression in Prokaryotes

The Control of Gene Expression in Eukaryotes

Sensory Systems

The Immune System

Molecular Motors

Filters

Which of the following drugs were developed as a result of information obtained from a mouse model that had the gene that normally produces the α-subunit of the H⁺,K⁺ ATPase transport system "knocked out"?

Sketch the binding curve for the titration of a receptor R with a ligand L,and label the point on the plot that corresponds to the K_d for the RL complex.

Drug candidateIC₅₀(nmol)Log (P)C_max (µM)BioavailabilityA0.44.67<0.1B0.013.70<0.1C0.33.690.7D0.62.9211Consider the information concerning a related class of potential drugs in the table above.Which one would be the best candidate for further testing?