Question 1

What is the explanation for the relatively high frequency of rare autosomal recessive disorders in the Old Order Amish population?

Accepted Answer

A)  Assortative mating 
B)  Positive selection 
C)  Negative selection 
D)  Founder effect 
E)  Heterozygote advantage 
A)  Assortative mating 
B)  Positive selection 
C)  Negative selection 
D)  Founder effect 
E)  Heterozygote advantage D

Question 2

What is θ a measure of?

Accepted Answer

A)  Distance between genetic loci 
B)  Natural selection 
C)  Genetic drift 
D)  Migration 
E)  Genetic contribution to a trait 
A)  Distance between genetic loci 
B)  Natural selection 
C)  Genetic drift 
D)  Migration 
E)  Genetic contribution to a trait A

Question 3

The strategy behind association analyses is to look in affected populations for allele sharing in which of the following?

Accepted Answer

A)  The disease gene 
B)  The disease chromosome 
C)  The founder haplotype 
D)  Regions of homozygosity 
E)  Regions of similarity 
A)  The disease gene 
B)  The disease chromosome 
C)  The founder haplotype 
D)  Regions of homozygosity 
E)  Regions of similarity C

Question 4

To search for loci involved in autosomal recessive diseases,which alternative approach to a traditional linkage analysis can be used?

Accepted Answer

A)  Look for shared alleles between affected families 
B)  Look for shared regions of deletion between affected families 
C)  Look for regions of homozygosity in affected families 
D)  Look for uniparental heterodisomy 
E)  Look for uniparental homodisomy 
A)  Look for shared alleles between affected families 
B)  Look for shared regions of deletion between affected families 
C)  Look for regions of homozygosity in affected families 
D)  Look for uniparental heterodisomy 
E)  Look for uniparental homodisomy

Question 5

Which of the following can disturb Hardy-Weinberg equilibrium?

Accepted Answer

A)  Assortative mating 
B)  Natural selection 
C)  Population bottleneck 
D)  A small population size 
E)  All of the above 
A)  Assortative mating 
B)  Natural selection 
C)  Population bottleneck 
D)  A small population size 
E)  All of the above

Question 6

Which of the following is a type of association analysis that is designed to avoid issues with population stratification?

Accepted Answer

A)  Case-control study 
B)  Transmission disequilibrium test 
C)  Autozygosity mapping 
D)  Affected sib pair method 
E)  NPL analysis 
A)  Case-control study 
B)  Transmission disequilibrium test 
C)  Autozygosity mapping 
D)  Affected sib pair method 
E)  NPL analysis

Question 7

The incidence of cystic fibrosis in the Caucasian population is approximately 1 in 4000-what is the carrier frequency?

Accepted Answer

A)  1/16 
B)  1/32 
C)  1/64 
D)  1/128 
E)  1/1000 
A)  1/16 
B)  1/32 
C)  1/64 
D)  1/128 
E)  1/1000

Question 8

How are the LOD scores from multiple affected families combined?

Accepted Answer

A)  Added 
B)  Subtracted 
C)  Averaged 
D)  Multiplied 
E)  They cannot be combined 
A)  Added 
B)  Subtracted 
C)  Averaged 
D)  Multiplied 
E)  They cannot be combined

Question 9

What has led to the rise in frequency of the alleles for the sickle cell trait?

Accepted Answer

A)  Genetic drift 
B)  Population bottleneck 
C)  Heterozygote advantage 
D)  Negative selection 
E)  Assortative mating 
A)  Genetic drift 
B)  Population bottleneck 
C)  Heterozygote advantage 
D)  Negative selection 
E)  Assortative mating

Question 10

How is artificial selection against a genetic disorder predicted to affect the disease incidence in the autosomal dominant and autosomal recessive cases,respectively?

Accepted Answer

A)  Decrease rapidly, decrease rapidly 
B)  Decrease rapidly, decrease slowly 
C)  Decrease slowly, decrease rapidly 
D)  Stay the same, decrease slowly 
E)  Decrease slowly, stay the same 
A)  Decrease rapidly, decrease rapidly 
B)  Decrease rapidly, decrease slowly 
C)  Decrease slowly, decrease rapidly 
D)  Stay the same, decrease slowly 
E)  Decrease slowly, stay the same

Question 11

Which of the following describes the relative genotype frequencies in a randomly mating population?

Accepted Answer

A)  Law of random segregation 
B)  Law of natural selection 
C)  Hardy-Weinberg principle 
D)  Law of independent assortment 
E)  Darwin's principle 
A)  Law of random segregation 
B)  Law of natural selection 
C)  Hardy-Weinberg principle 
D)  Law of independent assortment 
E)  Darwin's principle

Question 12

In a linkage analysis,given that you do not know the distance between a marker and the disease locus,the calculation is reiterated for many values of θ.How,then,is one LOD score selected from these data?

Accepted Answer

A)  The lowest θ is chosen 
B)  The highest θ is chosen 
C)  The θ associated with the lowest LOD is chosen 
D)  The θ associated with the highest LOD is chosen 
E)  You must take into account information from surrounding markers 
A)  The lowest θ is chosen 
B)  The highest θ is chosen 
C)  The θ associated with the lowest LOD is chosen 
D)  The θ associated with the highest LOD is chosen 
E)  You must take into account information from surrounding markers

Question 13

What selective agent has resulted in heterozygote advantage for thalassemia mutation carriers?

Accepted Answer

A)  Influenza 
B)  Plague 
C)  Tuberculosis 
D)  AIDS 
E)  Falciparum malaria 
A)  Influenza 
B)  Plague 
C)  Tuberculosis 
D)  AIDS 
E)  Falciparum malaria

What is the explanation for the relatively high frequency of rare autosomal recessive disorders in the Old Order Amish population?

What is θ a measure of?

The strategy behind association analyses is to look in affected populations for allele sharing in which of the following?

To search for loci involved in autosomal recessive diseases,which alternative approach to a traditional linkage analysis can be used?

Which of the following can disturb Hardy-Weinberg equilibrium?

Which of the following is a type of association analysis that is designed to avoid issues with population stratification?

The incidence of cystic fibrosis in the Caucasian population is approximately 1 in 4000-what is the carrier frequency?

How are the LOD scores from multiple affected families combined?

What has led to the rise in frequency of the alleles for the sickle cell trait?

How is artificial selection against a genetic disorder predicted to affect the disease incidence in the autosomal dominant and autosomal recessive cases,respectively?

Which of the following describes the relative genotype frequencies in a randomly mating population?

In a linkage analysis,given that you do not know the distance between a marker and the disease locus,the calculation is reiterated for many values of θ.How,then,is one LOD score selected from these data?

What selective agent has resulted in heterozygote advantage for thalassemia mutation carriers?

The History and Impact of Genetics in Medicine

The Cellular and Molecular Basis of Inheritance

Chromosomes and Cell Division

Dna Technology and Applications

Mapping and Identifying Genes for Monogenic Disorders

Developmental Genetics

Patterns of Inheritance

Polygenic and Multifactorial Inheritance

Hemoglobin and the Hemoglobinopathies

Biochemical Genetics

Pharmacogenetics

Immunogenetics

Cancer Genetics

Genetic Factors in Common Diseases

Congenital Abnormalities and Dysmorphic Syndromes

Genetic Counseling

Chromosome Disorders

Single-Gene Disorders

Screening for Genetic Disease

Prenatal Testing and Reproductive Genetics

Risk Calculation

Treatment of Genetic Disease

Ethical and Legal Issues in Medical Genetics

Filters

Exam 8: Population and Mathematical Genetics

What is the explanation for the relatively high frequency of rare autosomal recessive disorders in the Old Order Amish population?

What is θ a measure of?

The strategy behind association analyses is to look in affected populations for allele sharing in which of the following?

To search for loci involved in autosomal recessive diseases,which alternative approach to a traditional linkage analysis can be used?

Which of the following can disturb Hardy-Weinberg equilibrium?

Which of the following is a type of association analysis that is designed to avoid issues with population stratification?

The incidence of cystic fibrosis in the Caucasian population is approximately 1 in 4000-what is the carrier frequency?

How are the LOD scores from multiple affected families combined?

What has led to the rise in frequency of the alleles for the sickle cell trait?

How is artificial selection against a genetic disorder predicted to affect the disease incidence in the autosomal dominant and autosomal recessive cases,respectively?

Which of the following describes the relative genotype frequencies in a randomly mating population?

In a linkage analysis,given that you do not know the distance between a marker and the disease locus,the calculation is reiterated for many values of θ.How,then,is one LOD score selected from these data?

What selective agent has resulted in heterozygote advantage for thalassemia mutation carriers?

The History and Impact of Genetics in Medicine

The Cellular and Molecular Basis of Inheritance

Chromosomes and Cell Division

Dna Technology and Applications

Mapping and Identifying Genes for Monogenic Disorders

Developmental Genetics

Patterns of Inheritance

Polygenic and Multifactorial Inheritance

Hemoglobin and the Hemoglobinopathies

Biochemical Genetics

Pharmacogenetics

Immunogenetics

Cancer Genetics

Genetic Factors in Common Diseases

Congenital Abnormalities and Dysmorphic Syndromes

Genetic Counseling

Chromosome Disorders

Single-Gene Disorders

Screening for Genetic Disease

Prenatal Testing and Reproductive Genetics

Risk Calculation

Treatment of Genetic Disease

Ethical and Legal Issues in Medical Genetics

Filters