Question 1

Which of the following is a property of the system of triplet codons for amino acids?

Accepted Answer

A)  Multiple codons can specify the same amino acid 
B)  The codons specified by nuclear DNA are the same as those specified by mtDNA 
C)  There is one stop codon 
D)  Each amino acid is specified by one codon 
E)  Each codon pairs to a unique tRNA 
A)  Multiple codons can specify the same amino acid 
B)  The codons specified by nuclear DNA are the same as those specified by mtDNA 
C)  There is one stop codon 
D)  Each amino acid is specified by one codon 
E)  Each codon pairs to a unique tRNA A

Question 2

How many types of RNA are involved in translation?

Accepted Answer

A)  1 
B)  2 
C)  3 
D)  4 
A)  1 
B)  2 
C)  3 
D)  4 C

Question 3

Which of the following are sequences that closely resemble other genes but are not themselves functionally expressed?

Accepted Answer

A)  Introns 
B)  Pseudogenes 
C)  Satellite DNA 
D)  Tandem repeats 
E)  Junk DNA 
A)  Introns 
B)  Pseudogenes 
C)  Satellite DNA 
D)  Tandem repeats 
E)  Junk DNA B

Question 4

In genetic expansions of a repeat encoding which amino acid are known to be pathogenic?

Accepted Answer

A)  Alanine 
B)  Glutamine 
C)  Glycine 
D)  Proline 
E)  Methionine 
A)  Alanine 
B)  Glutamine 
C)  Glycine 
D)  Proline 
E)  Methionine

Question 5

Mutations in genes important for which pathway are often associated with cancer?

Accepted Answer

A)  DNA repair 
B)  Oxidative phosphorylation 
C)  DNA replication 
D)  Protein translation 
E)  All of the above 
A)  DNA repair 
B)  Oxidative phosphorylation 
C)  DNA replication 
D)  Protein translation 
E)  All of the above

Question 6

Which nucleotide base is unique to RNA?

Accepted Answer

A)  Adenine 
B)  Thymine 
C)  Guanine 
D)  Cytosine 
E)  Uracil 
A)  Adenine 
B)  Thymine 
C)  Guanine 
D)  Cytosine 
E)  Uracil

Question 7

Gain of function mutations exhibit which inheritance pattern?

Accepted Answer

A)  Dominant 
B)  Recessive 
C)  Dominant negative 
D)  Any of the above 
A)  Dominant 
B)  Recessive 
C)  Dominant negative 
D)  Any of the above

Question 8

Which of the following distinguishes lagging strand from leading strand synthesis during DNA replication?

Accepted Answer

A)  5' to 3' direction 
B)  Continuous synthesis 
C)  Okazaki fragments 
D)  Requirement for DNA polymerase 
E)  Requirement for DNA helicase 
A)  5' to 3' direction 
B)  Continuous synthesis 
C)  Okazaki fragments 
D)  Requirement for DNA polymerase 
E)  Requirement for DNA helicase

Question 9

Which of the following is an example of repetitive DNA?

Accepted Answer

A)  Microsatellite 
B)  Minisatellite 
C)  Telomere 
D)  SINE 
E)  All of the above 
A)  Microsatellite 
B)  Minisatellite 
C)  Telomere 
D)  SINE 
E)  All of the above

Question 10

Which of the following mutations would not be transmitted to the next generation?

Accepted Answer

A)  Somatic mutation 
B)  Mosaic mutation 
C)  Germline mutation 
D)  Nonsense mutation 
E)  Silent mutation 
A)  Somatic mutation 
B)  Mosaic mutation 
C)  Germline mutation 
D)  Nonsense mutation 
E)  Silent mutation

Question 11

Which of the following describes the orientation of the two strands of DNA?

Accepted Answer

A)  Parallel 
B)  Antiparallel 
C)  Inverse 
D)  Homologous 
A)  Parallel 
B)  Antiparallel 
C)  Inverse 
D)  Homologous

Question 12

Which of the following are cis-acting elements involved in regulation of gene expression?

Accepted Answer

A)  Transcription factors 
B)  Hormone nuclear receptors 
C)  Signal transduction proteins 
D)  miRNAs 
E)  Enhancers 
A)  Transcription factors 
B)  Hormone nuclear receptors 
C)  Signal transduction proteins 
D)  miRNAs 
E)  Enhancers

Question 13

Which of the following are encoded by the mitochondrial genome?

Accepted Answer

A)  All mitochondrial proteins 
B)  Mitochondrial DNA polymerase 
C)  Proteins involved in oxidative phosphorylation 
D)  Mitochondrial transcription factors 
E)  Ribosomal proteins 
A)  All mitochondrial proteins 
B)  Mitochondrial DNA polymerase 
C)  Proteins involved in oxidative phosphorylation 
D)  Mitochondrial transcription factors 
E)  Ribosomal proteins

Question 14

Which of the following are involved in translational regulation?

Accepted Answer

A)  rRNA 
B)  miRNA 
C)  tRNA 
D)  mRNA 
E)  All of the above 
A)  rRNA 
B)  miRNA 
C)  tRNA 
D)  mRNA 
E)  All of the above

Question 15

Which of the following mutations would be least likely to be associated with loss of the encoded protein?

Accepted Answer

A)  Nonsense mutation 
B)  Deletion 
C)  Splice site mutation 
D)  Missense mutation 
E)  Insertion 
A)  Nonsense mutation 
B)  Deletion 
C)  Splice site mutation 
D)  Missense mutation 
E)  Insertion

Question 16

Disease-causing trinucleotide repeat expansions are found in which part of a gene?

Accepted Answer

A)  5' UTR 
B)  Coding region 
C)  Intron 
D)  3' UTR 
E)  All of the above 
A)  5' UTR 
B)  Coding region 
C)  Intron 
D)  3' UTR 
E)  All of the above

Which of the following is a property of the system of triplet codons for amino acids?

How many types of RNA are involved in translation?

Which of the following are sequences that closely resemble other genes but are not themselves functionally expressed?

In genetic expansions of a repeat encoding which amino acid are known to be pathogenic?

Mutations in genes important for which pathway are often associated with cancer?

Which nucleotide base is unique to RNA?

Gain of function mutations exhibit which inheritance pattern?

Which of the following distinguishes lagging strand from leading strand synthesis during DNA replication?

Which of the following is an example of repetitive DNA?

Which of the following mutations would not be transmitted to the next generation?

Which of the following describes the orientation of the two strands of DNA?

Which of the following are cis-acting elements involved in regulation of gene expression?

Which of the following are encoded by the mitochondrial genome?

Which of the following are involved in translational regulation?

Which of the following mutations would be least likely to be associated with loss of the encoded protein?

Disease-causing trinucleotide repeat expansions are found in which part of a gene?

The History and Impact of Genetics in Medicine

Chromosomes and Cell Division

Dna Technology and Applications

Mapping and Identifying Genes for Monogenic Disorders

Developmental Genetics

Patterns of Inheritance

Population and Mathematical Genetics

Polygenic and Multifactorial Inheritance

Hemoglobin and the Hemoglobinopathies

Biochemical Genetics

Pharmacogenetics

Immunogenetics

Cancer Genetics

Genetic Factors in Common Diseases

Congenital Abnormalities and Dysmorphic Syndromes

Genetic Counseling

Chromosome Disorders

Single-Gene Disorders

Screening for Genetic Disease

Prenatal Testing and Reproductive Genetics

Risk Calculation

Treatment of Genetic Disease

Ethical and Legal Issues in Medical Genetics

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Exam 2: The Cellular and Molecular Basis of Inheritance

Which of the following is a property of the system of triplet codons for amino acids?

How many types of RNA are involved in translation?

Which of the following are sequences that closely resemble other genes but are not themselves functionally expressed?

In genetic expansions of a repeat encoding which amino acid are known to be pathogenic?

Mutations in genes important for which pathway are often associated with cancer?

Which nucleotide base is unique to RNA?

Gain of function mutations exhibit which inheritance pattern?

Which of the following distinguishes lagging strand from leading strand synthesis during DNA replication?

Which of the following is an example of repetitive DNA?

Which of the following mutations would not be transmitted to the next generation?

Which of the following describes the orientation of the two strands of DNA?

Which of the following are cis-acting elements involved in regulation of gene expression?

Which of the following are encoded by the mitochondrial genome?

Which of the following are involved in translational regulation?

Which of the following mutations would be least likely to be associated with loss of the encoded protein?

Disease-causing trinucleotide repeat expansions are found in which part of a gene?

The History and Impact of Genetics in Medicine

Chromosomes and Cell Division

Dna Technology and Applications

Mapping and Identifying Genes for Monogenic Disorders

Developmental Genetics

Patterns of Inheritance

Population and Mathematical Genetics

Polygenic and Multifactorial Inheritance

Hemoglobin and the Hemoglobinopathies

Biochemical Genetics

Pharmacogenetics

Immunogenetics

Cancer Genetics

Genetic Factors in Common Diseases

Congenital Abnormalities and Dysmorphic Syndromes

Genetic Counseling

Chromosome Disorders

Single-Gene Disorders

Screening for Genetic Disease

Prenatal Testing and Reproductive Genetics

Risk Calculation

Treatment of Genetic Disease

Ethical and Legal Issues in Medical Genetics

Filters