In a Linkage Analysis,given That You Do Not Know the Distance

In a linkage analysis,given that you do not know the distance between a marker and the disease locus,the calculation is reiterated for many values of θ.How,then,is one LOD score selected from these data?

A) The lowest θ is chosen
B) The highest θ is chosen
C) The θ associated with the lowest LOD is chosen
D) The θ associated with the highest LOD is chosen
E) You must take into account information from surrounding markers

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