Question 1

In older patients, drugs metabolism differs from a middle aged adult due:

Accepted Answer

A)  The increased number of enzymes the older patient has 
B)  The decreased function of the enzymes in the older patient 
C)  Lack of disease processes occurring in the older patient 
D)  The increased number of medications the middle aged patient is taking versus the older patient 
A)  The increased number of enzymes the older patient has 
B)  The decreased function of the enzymes in the older patient 
C)  Lack of disease processes occurring in the older patient 
D)  The increased number of medications the middle aged patient is taking versus the older patient B

Question 2

A pharmacist is teaching pharmacokinetics to the pharmacology class. What statement, made by a student, would show the class understands this term?

Accepted Answer

A)  "Pharmacokinetics is what the body does to a drug." 
B)  "Pharmacokinetics is how drugs activate specific receptors." 
C)  "Pharmacokinetics is what a drug does to the body." 
D)  "Pharmacokinetics is the efficacy of a drug." 
A)  "Pharmacokinetics is what the body does to a drug." 
B)  "Pharmacokinetics is how drugs activate specific receptors." 
C)  "Pharmacokinetics is what a drug does to the body." 
D)  "Pharmacokinetics is the efficacy of a drug." A

Question 3

The dose that is routinely given to maintain the concentration of the drug once the therapeutic level is reached is called:

Accepted Answer

A)  The effective dose 
B)  The maintenance dose 
C)  The loading dose 
D)  The standing order 
A)  The effective dose 
B)  The maintenance dose 
C)  The loading dose 
D)  The standing order B

Question 4

When components of bile are circulated back to the liver from the intestines, this is referred to as

Accepted Answer

A)  Elimination 
B)  Enterohepatic recirculation 
C)  Hepatic portal vein circulation 
D)  First-pass effect 
A)  Elimination 
B)  Enterohepatic recirculation 
C)  Hepatic portal vein circulation 
D)  First-pass effect

Question 5

Thomas Belliveau is taking one drug four times a day and another drug once daily. He has also started showing decreased liver function. Using the principles discussed in this chapter, explain why one drug needs to be taken only once a day and the second one is taken four times a day to obtain the therapeutic effect. What would probably happen to his dosing due to the decreased liver function?

Accepted Answer

The drug Thomas is taking that is taken

Question 6

Drugs such as ramipril, losartan, and codeine are called prodrugs because they:

Accepted Answer

A)  Require the liver to metabolize the drug in order to make it inactive 
B)  Require enterohepatic recirculation in order to be active 
C)  Need other drugs to be taken at the same time to "turn them on" and make them active 
D)  Require metabolism in order to become active in the body 
A)  Require the liver to metabolize the drug in order to make it inactive 
B)  Require enterohepatic recirculation in order to be active 
C)  Need other drugs to be taken at the same time to "turn them on" and make them active 
D)  Require metabolism in order to become active in the body

Question 7

If a drug is taken on an empty stomach, it will be absorbed slower than if taken on a full stomach.

Accepted Answer

A) True 
 B)False

Question 8

A dose higher than normal, such as a double dose, is given in order to reach the therapeutic range faster. This dose is referred to as:

Accepted Answer

A)  The maintenance dose 
B)  The toxic dose 
C)  The effective dose 
D)  The loading dose 
A)  The maintenance dose 
B)  The toxic dose 
C)  The effective dose 
D)  The loading dose

Question 9

Alternative routes of drug delivery, other than oral, may be needed if the drug is subject to the first-pass effect.

Accepted Answer

A) True 
 B)False

Question 10

When drugs are taken together and one drug pushes the other drug below the minimum toxic concentration, side effects typically occur.

Accepted Answer

A) True 
 B)False

Question 11

A prodrug is active as soon as it is absorbed into the body.

Accepted Answer

A) True 
 B)False

Question 12

If a drug is bound to a plasma protein, it is active.

Accepted Answer

A) True 
 B)False

Question 13

Dosing in pediatrics has to be adjusted due to their under developed metabolic enzymes.

Accepted Answer

A) True 
 B)False

Question 14

When a double dose is given on the first day of therapy in order to read the therapeutic concentration of the drug faster, this dose is referred to as the loading dose.

Accepted Answer

A) True 
 B)False

Question 15

Which factor would cause quicker absorption?

Accepted Answer

A)  Solid form versus liquid form 
B)  Able to mix with water 
C)  Product is warm versus cold 
D)  Large particle size 
A)  Solid form versus liquid form 
B)  Able to mix with water 
C)  Product is warm versus cold 
D)  Large particle size

Question 16

Drugs that slow down an enzyme in the CYP450 isoenzyme system would be called:

Accepted Answer

A)  Substrates 
B)  Inducers 
C)  Inhibitors 
D)  Co-enzymes 
A)  Substrates 
B)  Inducers 
C)  Inhibitors 
D)  Co-enzymes

Question 17

For a drug to produce a therapeutic effect, its blood concentration must surpass this level and below it, the drug is not effective.

Accepted Answer

A)  Minimum toxic concentration 
B)  Therapeutic window 
C)  Minimum effective concentration 
D)  Loading dose 
A)  Minimum toxic concentration 
B)  Therapeutic window 
C)  Minimum effective concentration 
D)  Loading dose

Question 18

The plasma membrane consists of a lipid bilayer that is relatively impermeable to which of the following:

Accepted Answer

A)  Small molecules 
B)  Ions 
C)  Non polar molecules 
D)  Water soluble molecules 
A)  Small molecules 
B)  Ions 
C)  Non polar molecules 
D)  Water soluble molecules

Question 19

If a pregnant women takes a drug, it will not affect the fetus because it is blocked by the blood-placenta barrier.

Accepted Answer

A) True 
 B)False

Question 20

Drugs can be excreted from the body via sweat glands, mammary glands, bile, urine, and feces, and by respiration.

Accepted Answer

A) True 
 B)False

Exam 4: Pharmacokinetics

In older patients, drugs metabolism differs from a middle aged adult due:

A pharmacist is teaching pharmacokinetics to the pharmacology class. What statement, made by a student, would show the class understands this term?

The dose that is routinely given to maintain the concentration of the drug once the therapeutic level is reached is called:

When components of bile are circulated back to the liver from the intestines, this is referred to as

Drugs such as ramipril, losartan, and codeine are called prodrugs because they:

If a drug is taken on an empty stomach, it will be absorbed slower than if taken on a full stomach.

A dose higher than normal, such as a double dose, is given in order to reach the therapeutic range faster. This dose is referred to as:

Alternative routes of drug delivery, other than oral, may be needed if the drug is subject to the first-pass effect.

When drugs are taken together and one drug pushes the other drug below the minimum toxic concentration, side effects typically occur.

A prodrug is active as soon as it is absorbed into the body.

If a drug is bound to a plasma protein, it is active.

Dosing in pediatrics has to be adjusted due to their under developed metabolic enzymes.

When a double dose is given on the first day of therapy in order to read the therapeutic concentration of the drug faster, this dose is referred to as the loading dose.

Which factor would cause quicker absorption?

Drugs that slow down an enzyme in the CYP450 isoenzyme system would be called:

For a drug to produce a therapeutic effect, its blood concentration must surpass this level and below it, the drug is not effective.

The plasma membrane consists of a lipid bilayer that is relatively impermeable to which of the following:

If a pregnant women takes a drug, it will not affect the fetus because it is blocked by the blood-placenta barrier.

Drugs can be excreted from the body via sweat glands, mammary glands, bile, urine, and feces, and by respiration.

The Practice of Pharmacy

Drug Classification, Regulation, and Approval

Drug Forms and Routes of Drug Administration

Pharmacodynamics

Substance Abuse

Using Drug References

Drugs for Disorders Associated With the Autonomic Nervous System

Drugs for Anxiety, Daytime Sedation, and Insomnia

Drugs for Emotional, Behavioural, and Mood Disorders

Drugs for Psychoses and Degenerative Diseases

Drugs for Seizures

Drugs for the Control of Pain and Fever

Drugs for Local and General Anaesthesia

Drugs for Coagulation Disorders

Drugs for Hypertension

Drugs for Heart Failure

Drugs for Dysrhythmias

Drugs for Chest Pain, Myocardial Infraction, and Stroke

Drugs for Lipid Disorders

Drugs for Shock and Anaphylaxis

Drugs for Kidney, Acid-Base, and Electrolyte Disorders

Drugs for Bacterial Infections

Drugs for Fungal, Viral, and Parasitic Diseases

Drugs for Neoplasia

Drugs for Respiratory Disorders

Drugs for Immune System Modulation

Drugs for Eye and Ear Disorders

Drugs for Gastrointestinal Disorders

Vitamins, Minerals, and Nutritional Supplments

Drugs for Muscle Spasm and Bone Disorder

Drugs for Skin Disorders

Drugs for Endocrine Disorders

Drugs for Disorders and Conditions of the Reproductive System

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