Question 1

In the conversion of glucose to pyruvate, how many of the actual steps involve electron transfer?

Accepted Answer

A)  none 
B)  1 
C)  2 
D)  3 
E)  4 
A)  none 
B)  1 
C)  2 
D)  3 
E)  4

Question 2

Which of the following enzymes of glycolysis is not involved in regulation of the pathway?

Accepted Answer

A)  Hexokinase 
B)  Phosphofructokinase 
C)  Aldolase 
D)  Pyruvate kinase 
E)  All of these proteins regulate glycolysis. 
A)  Hexokinase 
B)  Phosphofructokinase 
C)  Aldolase 
D)  Pyruvate kinase 
E)  All of these proteins regulate glycolysis.

Question 3

Which of the following is not an end product of glucose metabolism via either aerobic or anaerobic means?

Accepted Answer

A)  ethanol 
B)  carbon dioxide 
C)  lactate 
D)  fructose 
E)  all of these are end products of glucose metabolism 
A)  ethanol 
B)  carbon dioxide 
C)  lactate 
D)  fructose 
E)  all of these are end products of glucose metabolism

Question 4

The fate of pyruvate produced during glycolysis depends primarily on the availability of

Accepted Answer

A)  NAD+ to keep the pathway going. 
B)  molecular oxygen. 
C)  ADP for conversion to ATP. 
D)  coenzyme A for further metabolism of pyruvate. 
E)  phosphoric acid for the synthesis of ATP. 
A)  NAD+ to keep the pathway going. 
B)  molecular oxygen. 
C)  ADP for conversion to ATP. 
D)  coenzyme A for further metabolism of pyruvate. 
E)  phosphoric acid for the synthesis of ATP.

Question 5

During glycolysis, ATP is synthesized from ADP and a phosphate group transferred from an acid anhydride.

Accepted Answer

A) True 
 B)False

Question 6

During anaerobic metabolism in yeast, the carbons of glucose end up in

Accepted Answer

A)  CO2. 
B)  ethanol. 
C)  lactic acid. 
D)  both CO2 and ethanol. 
E)  all of these 
A)  CO2. 
B)  ethanol. 
C)  lactic acid. 
D)  both CO2 and ethanol. 
E)  all of these

Question 7

The fate of NADH from glycolysis depends on whether conditions are anaerobic or aerobic.

Accepted Answer

A) True 
 B)False

Question 8

The binding of glucose to hexokinase

Accepted Answer

A)  is an example of lock-and-key binding of a substrate to the active site of an enzyme. 
B)  is an example of induced-fit binding of a substrate to the active site of an enzyme. 
C)  differs from the binding of substrates to other kinases. 
D)  is not well characterized. 
A)  is an example of lock-and-key binding of a substrate to the active site of an enzyme. 
B)  is an example of induced-fit binding of a substrate to the active site of an enzyme. 
C)  differs from the binding of substrates to other kinases. 
D)  is not well characterized.

Question 9

The percentage of energy captured as ATP during the conversion of glucose to lactate is closest to

Accepted Answer

A)  10%. 
B)  30%. 
C)  50%. 
D)  75%. 
E)  90%. 
A)  10%. 
B)  30%. 
C)  50%. 
D)  75%. 
E)  90%.

Question 10

The ΔG values for glycolytic reactions at physiological conditions may be exergonic, even though the ΔG°' at "standard" conditions, may be endergonic.

Accepted Answer

A) True 
 B)False

Question 11

The nicotinamide-binding region in glyceraldehyde-3-phosphate dehydrogenase is similar to all other NAD binding domains.

Accepted Answer

A) True 
 B)False

Question 12

Which of the following enzymes catalyzes the cleavage of fructose bisphosphate into two 3-carbon units?

Accepted Answer

A)  Aldolase 
B)  Enolase 
C)  An isomerase 
D)  A mutase 
E)  None of these enzymes carries out that reaction. 
A)  Aldolase 
B)  Enolase 
C)  An isomerase 
D)  A mutase 
E)  None of these enzymes carries out that reaction.

Question 13

The equilibrium for isomerization of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate is favored because

Accepted Answer

A)  the standard free energy is negative 
B)  glyceraldehyde-3-phosphate is being continuously drained off for the subsequent reaction in the glycolytic pathway 
C)  the value of the equilibrium constant favors the reaction 
D)  it is driven by the hydrolysis of ATP 
A)  the standard free energy is negative 
B)  glyceraldehyde-3-phosphate is being continuously drained off for the subsequent reaction in the glycolytic pathway 
C)  the value of the equilibrium constant favors the reaction 
D)  it is driven by the hydrolysis of ATP

Question 14

How many steps in glycolysis have ATP as a substrate or product?

Accepted Answer

A)  zero 
B)  1 
C)  2 
D)  4 
E)  6
F) none of these 
A)  zero 
B)  1 
C)  2 
D)  4 
E)  6
F) none of these

Question 15

The step that commits the cell to metabolize glucose is catalyzed by

Accepted Answer

A)  hexokinase. 
B)  phosphoglucomutase. 
C)  aldolase. 
D)  phosphofructokinase. 
A)  hexokinase. 
B)  phosphoglucomutase. 
C)  aldolase. 
D)  phosphofructokinase.

Question 16

Consider the following information: phosphoenolpyruvate → pyruvate
ΔG°' = −61.9 kJ/mol
ADP + Pi → ATP
ΔG°' = +30.5 kJ/mol
How many molecules of ATP might theoretically have been produced when coupled to the conversion of one molecule phosphoenolpyruvate to pyruvate?

Accepted Answer

A)  1 
B)  2 
C)  3 
D)  4 
A)  1 
B)  2 
C)  3 
D)  4

Question 17

How many enzymes of glycolysis are control points for the pathway?

Accepted Answer

A)  1 
B)  2 
C)  3 
D)  4 
E)  All the enzymes serve as control points. 
A)  1 
B)  2 
C)  3 
D)  4 
E)  All the enzymes serve as control points.

Question 18

In the conversion of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate

Accepted Answer

A)  an alcohol group is phosphorylated. 
B)  an alcohol is oxidized to an aldehyde. 
C)  an alcohol is oxidized to a carboxylic acid. 
D)  an aldehyde is oxidized to a carboxylic acid. 
A)  an alcohol group is phosphorylated. 
B)  an alcohol is oxidized to an aldehyde. 
C)  an alcohol is oxidized to a carboxylic acid. 
D)  an aldehyde is oxidized to a carboxylic acid.

Question 19

The phosphorylation of fructose 6-phosphate to fructose-1,6-bisphosphate is the committed step in glycolysis because

Accepted Answer

A)  it is the rate-limiting step. 
B)  it is the most strongly exergonic step in the pathway. 
C)  fructose 1,6-bisphosphate can undergo no other reactions than those of glycolysis. 
D)  two phosphate groups are involved. 
A)  it is the rate-limiting step. 
B)  it is the most strongly exergonic step in the pathway. 
C)  fructose 1,6-bisphosphate can undergo no other reactions than those of glycolysis. 
D)  two phosphate groups are involved.

Question 20

During anaerobic metabolism in red blood cells, the carbons of glucose end up in

Accepted Answer

A)  CO2. 
B)  ethanol. 
C)  lactic acid. 
D)  both CO2 and ethanol. 
E)  all of the above. 
A)  CO2. 
B)  ethanol. 
C)  lactic acid. 
D)  both CO2 and ethanol. 
E)  all of the above.

Exam 17: Glycolysis

In the conversion of glucose to pyruvate, how many of the actual steps involve electron transfer?

Which of the following enzymes of glycolysis is not involved in regulation of the pathway?

Which of the following is not an end product of glucose metabolism via either aerobic or anaerobic means?

The fate of pyruvate produced during glycolysis depends primarily on the availability of

During glycolysis, ATP is synthesized from ADP and a phosphate group transferred from an acid anhydride.

During anaerobic metabolism in yeast, the carbons of glucose end up in

The fate of NADH from glycolysis depends on whether conditions are anaerobic or aerobic.

The binding of glucose to hexokinase

The percentage of energy captured as ATP during the conversion of glucose to lactate is closest to

The ΔG values for glycolytic reactions at physiological conditions may be exergonic, even though the ΔG°' at "standard" conditions, may be endergonic.

The nicotinamide-binding region in glyceraldehyde-3-phosphate dehydrogenase is similar to all other NAD binding domains.

Which of the following enzymes catalyzes the cleavage of fructose bisphosphate into two 3-carbon units?

The equilibrium for isomerization of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate is favored because

How many steps in glycolysis have ATP as a substrate or product?

The step that commits the cell to metabolize glucose is catalyzed by

Consider the following information: phosphoenolpyruvate → pyruvate ΔG°' = −61.9 kJ/mol ADP + Pi → ATP ΔG°' = +30.5 kJ/mol How many molecules of ATP might theoretically have been produced when coupled to the conversion of one molecule phosphoenolpyruvate to pyruvate?

How many enzymes of glycolysis are control points for the pathway?

In the conversion of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate

The phosphorylation of fructose 6-phosphate to fructose-1,6-bisphosphate is the committed step in glycolysis because

During anaerobic metabolism in red blood cells, the carbons of glucose end up in

Biochemistry and the Organization of Cells

Water: the Solvent for Biochemical Reactions

Amino Acids and Peptides

The Three-Dimensional Structure of Proteins

Protein Purification and Characterization Techniques

The Behavior of Proteins: Enzymes

The Behavior of Proteins: Enzymes, Mechanisms, and Control

Lipids and Proteins Are Associated in Biological Membranes

Nucleic Acids: How Structure Conveys Information

Biosynthesis of Nucleic Acids: Replication

Transcription of the Genetic Code: Biosynthesis of RNA

Protein Synthesis: Translation of the Genetic Message

Nucleic Acid Biotechnology Techniques

Viruses, Cancer, and Immunology

The Importance of Energy Changes and Electron Transfer in Metabolism

Carbohydrates

Storage Mechanisms and Control in Carbohydrate Metabolism

The Citric Acid Cycle

Electron Transport and Oxidative Phosphorylation

Lipid Metabolism

Photosynthesis

The Metabolism of Nitrogen

Integration of Metabolism: Cellular Signaling

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Consider the following information: phosphoenolpyruvate → pyruvate ΔG°' = −61.9 kJ/mol ADP + P_i → ATP ΔG°' = +30.5 kJ/mol How many molecules of ATP might theoretically have been produced when coupled to the conversion of one molecule phosphoenolpyruvate to pyruvate?