In Patients with 'CD40 Ligand Deficiency', T Cell-Dependent B Cell $\kappa$

In patients with 'CD40 ligand deficiency', T cell-dependent B cell activation is impaired, leading to poor antibody responses to protein antigens. The signaling pathway missing in these patients' B cells is important for:

A) Inducing integrin activation to promote adhesion
B) Inducing NF $\kappa$ B activation by the noncanonical pathway
C) Inducing WASp activation and actin polymerization
D) Inducing Ca²⁺ influx leading to NFAT activation
E) Inducing Ras activation and Erk Map-kinase signaling

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