Lymphocyte Activation Leads to Robust Proliferation and Effector Cell Differentiation

Lymphocyte activation leads to robust proliferation and effector cell differentiation. The metabolic demands of these processes are met, in part, by up-regulation of glycolytic enzymes and nutrient transporters on the activated cell membrane. A key intermediate in the signaling pathway leading to enhanced glucose metabolism following antigen receptor stimulation is:

A) The lipid mediator diacyl-glycerol (DAG)
B) The phosphoinositide, PIP₃
C) Increases in cytoplasmic Ca²⁺
D) Cleavage of the membrane phospholipid, PIP₂
E) The mitochondrial protein, Bcl-2

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