A 27-Year-Old Woman Visits the Office for a Routine Health

A 27-year-old woman visits the office for a routine health checkup. Neither the patient nor his or her family have a history of cancer. She has engaged in multiple sexual relationships and uses oral contraceptives to prevent pregnancy. The vital indicators are typical. It is typical to get a physical examination, including a pelvic exam. A squamous intraepithelial lesion that has tested positive for the human papillomavirus is discovered during a Pap test. A cervical biopsy is performed and reveals low-grade dysplasia.  Which of the following features distinguishes this patient's lesion from cervical malignancy?

A) Abundant mitoses
B) Disordered maturation
C) Loss of cell polarity
D) Nuclear abnormalities
E) Pleomorphism
F) Reversibility of changes

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