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Two Possible Mechanisms, Shown Below, Were Designed to Model the Activity

Question 269

Multiple Choice

Two possible mechanisms, shown below, were designed to model the activity of the enzyme phosphodiesterase (PDE) . Two possible mechanisms, shown below, were designed to model the activity of the enzyme phosphodiesterase (PDE) . Scientists have discovered that both nucleotides and phospholipids are susceptible to cleavage by PDE.  Which statement regarding the mechanism of PDE best explains their finding? A) Phospholipids bind PDE in Path 1, and nucleotides bind in Path 2. B) PDE uses Path 2 and undergoes a change in the active site. C) Breaking of phosphoester bonds in Path 1 and Path 2 releases energy. D) Binding either substrate induces a conformational change in Path 1. Scientists have discovered that both nucleotides and phospholipids are susceptible to cleavage by PDE.  Which statement regarding the mechanism of PDE best explains their finding?


A) Phospholipids bind PDE in Path 1, and nucleotides bind in Path 2.
B) PDE uses Path 2 and undergoes a change in the active site.
C) Breaking of phosphoester bonds in Path 1 and Path 2 releases energy.
D) Binding either substrate induces a conformational change in Path 1.

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