Several Tests Have Been Developed to Measure the Serologic Markers

Several tests have been developed to measure the serologic markers of breast cancer.  These tests have different specificities and sensitivities for the early stage of breast cancer.  If positive, which of the following tests will have the highest positive predictive value for the disease, assuming a prevalence of 10%?

A) Sensitivity - 65%, specificity - 97%
B) Sensitivity - 70%, specificity - 94%
C) Sensitivity - 75%, specificity - 92%
D) Sensitivity - 80%, specificity - 90%
E) Sensitivity - 85%, specificity - 90%

Correct Answer:

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