Researchers Are Observing How Coronary Blood Flow Changes in Response

Researchers are observing how coronary blood flow changes in response to progressive increases in the mean arterial blood pressure (see graph below) . The mostly horizontal portion of the slope indicates a region where coronary blood flow is relatively insensitive to blood pressure changes.  Within this zone of autoregulation, the metabolic demands of the myocardium are the main determinant of coronary blood flow.  Which of the following endogenous factors is most responsible for controlling coronary blood flow within this range?

A) Acetylcholine
B) Angiotensin II
C) Histamine
D) Nitric oxide
E) Norepinephrine
F) Serotonin

Correct Answer:

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