A 4-Week-Old Infant Is Evaluated for Frequent Episodes of Hypoglycemia

A 4-week-old infant is evaluated for frequent episodes of hypoglycemia.  The patient is found to have elevated insulin levels during periods of fasting.  Several members of his family have a similar condition.  Genetic testing reveals a mutation involving potassium channels expressed in pancreatic beta cells.  The mutated channels have a higher sensitivity to the substance that normally modulates their activity, causing increased beta cell secretory activity.  Which of the following substances normally binds to and regulates the ion channels that are responsible for this patient's hypoglycemia?

A) ATP
B) Citrate
C) Fructose-6-phosphate
D) Fumarate
E) Glucose
F) Lactate
G) Malate
H) Pyruvate

Correct Answer:

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