An 80-Year-Old Man Participates in a Study Designed to Evaluate

An 80-year-old man participates in a study designed to evaluate the effects of aging on the liver.  He has undergone a liver biopsy every 10 years since age 40 so that researchers can identify age-related histologic changes.  The subject is healthy and has no relevant family history.  He does not use alcohol or illicit drugs.  BMI is 21.5 kg/m².  Physical examination is unremarkable; laboratory studies, including complete blood count, liver function tests, cholesterol levels, and hemoglobin A1c, are within normal limits.  Which of the following histologic changes has most likely developed over time in this individual?

A) Extracellular amyloid deposition
B) Hemosiderin collections within hepatocytes
C) Hepatocyte intracytoplasmic hyaline inclusions
D) Lipofuscin deposition within hepatocytes
E) Stellate cell collagen production

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