Question 1

__________ is an approach that tries to get the immune system more involved in the fight against cancer.

Accepted Answer

A) Immunotherapy 
B) Gene therapy 
C) Inhibition of cancer-promoting proteins 
D) Inhibition of angiogenesis 
E) Hyposensitization 
A) Immunotherapy 
B) Gene therapy 
C) Inhibition of cancer-promoting proteins 
D) Inhibition of angiogenesis 
E) Hyposensitization

Question 2

Cancer results from the uncontrolled proliferation of a single wayward cell and is therefore considered to be _________.

Accepted Answer

A) polyclonal 
B) biclonal 
C) monoclonal 
D) variant 
E) obstreperous 
A) polyclonal 
B) biclonal 
C) monoclonal 
D) variant 
E) obstreperous

Question 3

Which molecule do Bexxar and Zevalin antibodies attack?

Accepted Answer

A) collagen 
B) CD20 
C) myeloid protein 
D) actin 
E) EGF receptor 
A) collagen 
B) CD20 
C) myeloid protein 
D) actin 
E) EGF receptor

Question 4

The genes involved in tumorigenesis constitute a specific subset of the genome whose products are involved in which of the following activities?

Accepted Answer

A) progression of a cell through the cell cycle 
B) adhesion of a cell to its neighbors 
C) apoptosis 
D) repair of DNA damage 
E) All of these are correct. 
A) progression of a cell through the cell cycle 
B) adhesion of a cell to its neighbors 
C) apoptosis 
D) repair of DNA damage 
E) All of these are correct.

Question 5

What is unusual about the inheritance of retinoblastoma,given that it appears to be inherited as a dominant trait?

Accepted Answer

A) All children who inherited one copy of the RB deletion developed retinoblastoma. 
B) Not all children who inherited the RB deletion developed retinoblastoma. 
C) No children who inherited the RB deletion developed retinoblastoma. 
D) Only boys appear to develop retinoblastoma. 
E) Only girls appear to develop retinoblastoma. 
A) All children who inherited one copy of the RB deletion developed retinoblastoma. 
B) Not all children who inherited the RB deletion developed retinoblastoma. 
C) No children who inherited the RB deletion developed retinoblastoma. 
D) Only boys appear to develop retinoblastoma. 
E) Only girls appear to develop retinoblastoma.

Question 6

Hypoxic conditions ___________.

Accepted Answer

A) cause cancer cells to activate a transcription factor called Hif 
B) can cause cancer cells to induce the formation of new blood vessels 
C) can promote the migratory properties of cancer cells 
D) can cause the spread of a tumor 
E) All of these are correct. 
A) cause cancer cells to activate a transcription factor called Hif 
B) can cause cancer cells to induce the formation of new blood vessels 
C) can promote the migratory properties of cancer cells 
D) can cause the spread of a tumor 
E) All of these are correct.

Question 7

If you could treat a tumor with an antibody against a factor that attracts blood vessels to the tumor,what might happen?

Accepted Answer

The antibody would interact with the fac

Question 8

What part of the cell cycle does the pRB protein help to regulate?

Accepted Answer

A) the S - G2 transition 
B) the G1 - S transition 
C) the G2 - M transition 
D) the G0 - G1 transition 
E) the M - G2 transition 
A) the S - G2 transition 
B) the G1 - S transition 
C) the G2 - M transition 
D) the G0 - G1 transition 
E) the M - G2 transition

Question 9

Judah Folkmann suggested that solid tumors __________.

Accepted Answer

A) might be destroyed by enhancing their ability to form new blood vessels 
B) might be dissipated by enhancing the ability of cancer cells to separate from each other 
C) might be destroyed by inhibiting their ability to form new blood vessels 
D) might be enlarged by breaking down neighboring tissues 
E) might be desiccated by osmotic action 
A) might be destroyed by enhancing their ability to form new blood vessels 
B) might be dissipated by enhancing the ability of cancer cells to separate from each other 
C) might be destroyed by inhibiting their ability to form new blood vessels 
D) might be enlarged by breaking down neighboring tissues 
E) might be desiccated by osmotic action

Question 10

Which of the following enzymes is known to be expressed at a high level in the cancer cells of patients suffering from acute myeloid leukemia and at low levels in the cancer cells of patients suffering from acute lymphoblastic leukemia?

Accepted Answer

A) cholesterase 
B) catalase 
C) adenylyl cyclase 
D) phosphodiesterase 
E) protein kinase A 
A) cholesterase 
B) catalase 
C) adenylyl cyclase 
D) phosphodiesterase 
E) protein kinase A

Question 11

The development of chronic myelogenous leukemia tumor-resistance to Gleevec appears to usually be caused by mutations in the ABL portion of the fusion gene.Therefore,what is thought to be the best drug regimen for treating CML?

Accepted Answer

A) a cocktail of several different inhibitors that target different parts of the Abl protein 
B) a cocktail of several different inhibitors that target the same parts of the Abl protein 
C) a cocktail of several different inhibitors that target common domains of different proteins 
D) a cocktail of several different inhibitors that target the different parts of different proteins 
E) an aperetif 
A) a cocktail of several different inhibitors that target different parts of the Abl protein 
B) a cocktail of several different inhibitors that target the same parts of the Abl protein 
C) a cocktail of several different inhibitors that target common domains of different proteins 
D) a cocktail of several different inhibitors that target the different parts of different proteins 
E) an aperetif

Question 12

What enzyme is responsible for maintaining the length of the DNA sequences on the ends of chromosomes (telomeres)?

Accepted Answer

A) tendrilase 
B) telomerase 
C) telomere synthase 
D) telomere disruptase 
E) telomere kinase 
A) tendrilase 
B) telomerase 
C) telomere synthase 
D) telomere disruptase 
E) telomere kinase

Question 13

The sis oncogene of the simian sarcoma virus was derived from what normal cellular gene?

Accepted Answer

A) the Ras gene 
B) the gene for platelet-derived growth factor (PDGF) 
C) the gene for the insulin receptor 
D) the gene for the glucagon receptor 
E) the gene for epidermal growth factor 
A) the Ras gene 
B) the gene for platelet-derived growth factor (PDGF) 
C) the gene for the insulin receptor 
D) the gene for the glucagon receptor 
E) the gene for epidermal growth factor

Question 14

____________ is a rare childhood cancer of the eye's retina.

Accepted Answer

A) Retinal carcinoma 
B) Eye cancer 
C) Retinal sarcoma 
D) Retinoblastoma 
E) Retinal epithelioma 
A) Retinal carcinoma 
B) Eye cancer 
C) Retinal sarcoma 
D) Retinoblastoma 
E) Retinal epithelioma

Question 15

The cancer vaccine DCVax utilizes which type of cells from the patient?

Accepted Answer

A) erythrocytes 
B) fibroblasts 
C) Schwann cells 
D) dendritic cells 
E) T cells 
A) erythrocytes 
B) fibroblasts 
C) Schwann cells 
D) dendritic cells 
E) T cells

Question 16

How does PTEN affect the balance between proapoptotic and antiapoptotic signals?

Accepted Answer

A) PTEN removes the phosphate group from the 3-position of PIP3 converting it to PI(4,5)P2,which cannot activate PKB (AKT)and thus throws the balance in an antiapoptotic direction. 
B) PTEN removes the phosphate group from the 3-position of PIP3 converting it to PI(4,5)P2,which cannot activate PKB (AKT)and thus throws the balance in a proapoptotic direction. 
C) PTEN cuts a phosphate group off of PKB,which throws the balance in a proapoptotic direction. 
D) PTEN cuts a phosphate group off of PKB,which throws the balance in an antiapoptotic direction. 
E) PTEN adds a phosphate group to PKB,which throws the balance in a proapoptotic direction. 
A) PTEN removes the phosphate group from the 3-position of PIP3 converting it to PI(4,5)P2,which cannot activate PKB (AKT)and thus throws the balance in an antiapoptotic direction. 
B) PTEN removes the phosphate group from the 3-position of PIP3 converting it to PI(4,5)P2,which cannot activate PKB (AKT)and thus throws the balance in a proapoptotic direction. 
C) PTEN cuts a phosphate group off of PKB,which throws the balance in a proapoptotic direction. 
D) PTEN cuts a phosphate group off of PKB,which throws the balance in an antiapoptotic direction. 
E) PTEN adds a phosphate group to PKB,which throws the balance in a proapoptotic direction.

Question 17

Which of the following is presently being used as a screening procedure for cancer?

Accepted Answer

A) mammography for detecting breast cancer 
B) Pap smears for detecting cervical cancer 
C) PSA determinations for detecting prostate cancer 
D) colonoscopy for detecting colorectal cancer 
E) All of these are correct. 
A) mammography for detecting breast cancer 
B) Pap smears for detecting cervical cancer 
C) PSA determinations for detecting prostate cancer 
D) colonoscopy for detecting colorectal cancer 
E) All of these are correct.

Question 18

Chronic infection with what stomach-dwelling bacterium has been associated with certain gastric lymphomas?

Accepted Answer

A) Escherichia coli 
B) Staphylococcus aureus 
C) Helicobacter pylori 
D) Saccharomyces cerevisiae 
E) Helicopter stomachus 
A) Escherichia coli 
B) Staphylococcus aureus 
C) Helicobacter pylori 
D) Saccharomyces cerevisiae 
E) Helicopter stomachus

Question 19

The first oncogene discovered was _____,which codes for a _______.

Accepted Answer

A) MYC,tyrosine protein kinase 
B) SRC,tyrosine protein kinase 
C) SRC,serine/threonine protein kinase 
D) MYC,serine/threonine protein kinase 
E) SRC,intermediary metabolism regulatory protein 
A) MYC,tyrosine protein kinase 
B) SRC,tyrosine protein kinase 
C) SRC,serine/threonine protein kinase 
D) MYC,serine/threonine protein kinase 
E) SRC,intermediary metabolism regulatory protein

Question 20

Mutant forms of which of the following genes have been associated with melanomas and colorectal cancers,respectively?

Accepted Answer

A) APC and BRAF 
B) BRAF and CCMD 
C) BRAF and APC 
D) CCMD and APC 
E) ZUNI and BRAF 
A) APC and BRAF 
B) BRAF and CCMD 
C) BRAF and APC 
D) CCMD and APC 
E) ZUNI and BRAF

__________ is an approach that tries to get the immune system more involved in the fight against cancer.

Cancer results from the uncontrolled proliferation of a single wayward cell and is therefore considered to be _________.

Which molecule do Bexxar and Zevalin antibodies attack?

The genes involved in tumorigenesis constitute a specific subset of the genome whose products are involved in which of the following activities?

What is unusual about the inheritance of retinoblastoma,given that it appears to be inherited as a dominant trait?

Hypoxic conditions ___________.

If you could treat a tumor with an antibody against a factor that attracts blood vessels to the tumor,what might happen?

What part of the cell cycle does the pRB protein help to regulate?

Judah Folkmann suggested that solid tumors __________.

Which of the following enzymes is known to be expressed at a high level in the cancer cells of patients suffering from acute myeloid leukemia and at low levels in the cancer cells of patients suffering from acute lymphoblastic leukemia?

The development of chronic myelogenous leukemia tumor-resistance to Gleevec appears to usually be caused by mutations in the ABL portion of the fusion gene.Therefore,what is thought to be the best drug regimen for treating CML?

What enzyme is responsible for maintaining the length of the DNA sequences on the ends of chromosomes (telomeres)?

The sis oncogene of the simian sarcoma virus was derived from what normal cellular gene?

____________ is a rare childhood cancer of the eye's retina.

The cancer vaccine DCVax utilizes which type of cells from the patient?

How does PTEN affect the balance between proapoptotic and antiapoptotic signals?

Which of the following is presently being used as a screening procedure for cancer?

Chronic infection with what stomach-dwelling bacterium has been associated with certain gastric lymphomas?

The first oncogene discovered was _,which codes for a ___.

Mutant forms of which of the following genes have been associated with melanomas and colorectal cancers,respectively?

Introduction to the Study of Cell and Molecular Biology

The Chemical Basis of Life

Bioenergetics,enzymes and Metabolism

The Structure and Function of the Plasma Membrane

Aerobic Respiration and the Mitochondrion

Photosynthesis and the Chloroplast

Interactions Between Cells and Their Environment

Cytoplasmic Membrane Systems: Structure, function, and Membrane Trafficking

The Cytoskeleton and Cell Motility

The Nature of the Gene and the Genome

Gene Expression: From Transcription to Translation

Control of Gene Expression

Dna Replication and Repair

Cellular Reproduction

Cell Signaling and Signal Transduction: Communication Between Cells

The Immune Response

Techniques in Cell and Molecular Biology

Filters

Exam 16: Cancer

__________ is an approach that tries to get the immune system more involved in the fight against cancer.

Cancer results from the uncontrolled proliferation of a single wayward cell and is therefore considered to be _________.

Which molecule do Bexxar and Zevalin antibodies attack?

The genes involved in tumorigenesis constitute a specific subset of the genome whose products are involved in which of the following activities?

What is unusual about the inheritance of retinoblastoma,given that it appears to be inherited as a dominant trait?

Hypoxic conditions ___________.

If you could treat a tumor with an antibody against a factor that attracts blood vessels to the tumor,what might happen?

What part of the cell cycle does the pRB protein help to regulate?

Judah Folkmann suggested that solid tumors __________.

Which of the following enzymes is known to be expressed at a high level in the cancer cells of patients suffering from acute myeloid leukemia and at low levels in the cancer cells of patients suffering from acute lymphoblastic leukemia?

The development of chronic myelogenous leukemia tumor-resistance to Gleevec appears to usually be caused by mutations in the ABL portion of the fusion gene.Therefore,what is thought to be the best drug regimen for treating CML?

What enzyme is responsible for maintaining the length of the DNA sequences on the ends of chromosomes (telomeres)?

The sis oncogene of the simian sarcoma virus was derived from what normal cellular gene?

____________ is a rare childhood cancer of the eye's retina.

The cancer vaccine DCVax utilizes which type of cells from the patient?

How does PTEN affect the balance between proapoptotic and antiapoptotic signals?

Which of the following is presently being used as a screening procedure for cancer?

Chronic infection with what stomach-dwelling bacterium has been associated with certain gastric lymphomas?

The first oncogene discovered was _____,which codes for a _______.

Mutant forms of which of the following genes have been associated with melanomas and colorectal cancers,respectively?

Introduction to the Study of Cell and Molecular Biology

The Chemical Basis of Life

Bioenergetics,enzymes and Metabolism

The Structure and Function of the Plasma Membrane

Aerobic Respiration and the Mitochondrion

Photosynthesis and the Chloroplast

Interactions Between Cells and Their Environment

Cytoplasmic Membrane Systems: Structure, function, and Membrane Trafficking

The Cytoskeleton and Cell Motility

The Nature of the Gene and the Genome

Gene Expression: From Transcription to Translation

Control of Gene Expression

Dna Replication and Repair

Cellular Reproduction

Cell Signaling and Signal Transduction: Communication Between Cells

The Immune Response

Techniques in Cell and Molecular Biology

Filters

The first oncogene discovered was _,which codes for a ___.