Question 1

Which of the following carbonyl compounds do not undergo Aldol addition reactions when treated with aqueous sodium hydroxide?

Accepted Answer

A)  I 
B)  II 
C)  III 
D)  IV 
A)  I 
B)  II 
C)  III 
D)  IV

Question 2

Which of the following compounds can undergo an Aldol with itself?

Accepted Answer

A)  I 
B)  II 
C)  III 
D)  Both I and II 
A)  I 
B)  II 
C)  III 
D)  Both I and II

Question 3

There are several variations of the Aldol reaction. Which of the following types of reactants leads to only one possible product with the Aldol condensation reaction?

Accepted Answer

A)  Two different aldehydes with F1F1F1S1F1F1F10-hydrogens are able to form a single aldol condensation product. 
B)  Two different ketones with F1F1F1S1F1F1F10-hydrogens are able to form a single aldol condensation product. 
C)  Any aldehyde and ketone mixed together can react to form a single condensation product. 
D)  Any pair of aldehyde or ketone reactants where one of the reactants has no F1F1F1S1F1F1F10-hydrogens will lead to a single aldol product. 
A)  Two different aldehydes with F1F1F1S1F1F1F10-hydrogens are able to form a single aldol condensation product. 
B)  Two different ketones with F1F1F1S1F1F1F10-hydrogens are able to form a single aldol condensation product. 
C)  Any aldehyde and ketone mixed together can react to form a single condensation product. 
D)  Any pair of aldehyde or ketone reactants where one of the reactants has no F1F1F1S1F1F1F10-hydrogens will lead to a single aldol product.

Question 4

What reaction type is a Claisen reaction?

Accepted Answer

A)  Electrophilic addition 
B)  Electrophilic substitution 
C)  Nucleophilic addition 
D)  Nucleophilic substitution 
A)  Electrophilic addition 
B)  Electrophilic substitution 
C)  Nucleophilic addition 
D)  Nucleophilic substitution

Question 5

What is the cyclic product formed in the intramolecular Aldol condensation when the following compound is treated with aqueous NaOH?

Accepted Answer

A)  I 
B)  II 
C)  III 
D)  IV 
A)  I 
B)  II 
C)  III 
D)  IV

Question 6

What is the product of the self-condensation of ethanal (acetaldehyde), shown below?

Accepted Answer

A)  I 
B)  II 
C)  III 
D)  IV 
A)  I 
B)  II 
C)  III 
D)  IV

Question 7

In the correct order, what are the three steps in the mechanism of an Aldol reaction?

Accepted Answer

A)  Protonation, enolate formation, nucleophilic addition. 
B)  Enolate formation, protonation, nucleophilic addition. 
C)  Enolate formation, nucleophilic addition, protonation. 
D)  Nucleophilic addition, enolate formation, protonation. 
A)  Protonation, enolate formation, nucleophilic addition. 
B)  Enolate formation, protonation, nucleophilic addition. 
C)  Enolate formation, nucleophilic addition, protonation. 
D)  Nucleophilic addition, enolate formation, protonation.

Question 8

What is the Aldol addition product formed from the reaction of acetone, (CH3)2CO, with itself?

Accepted Answer

A)  I 
B)  II 
C)  III 
D)  IV 
A)  I 
B)  II 
C)  III 
D)  IV

Question 9

Which is the unsaturated carbonyl compound formed in the dehydration of the following F1F1F1S1F1F1F10-hydroxy carbonyl compound?

Accepted Answer

A)  I 
B)  II 
C)  I and II 
D)  None of the choices 
A)  I 
B)  II 
C)  I and II 
D)  None of the choices

Question 10

What are the names for the two parts of the mechanism in a Robinson annulation?

Accepted Answer

A)  Michael addition and intramolecular Claisen reaction 
B)  Michael addition and intramolecular aldol reaction 
C)  Claisen reaction and intramolecular aldol reaction 
D)  Aldol reaction and intramolecular Claisen reaction 
A)  Michael addition and intramolecular Claisen reaction 
B)  Michael addition and intramolecular aldol reaction 
C)  Claisen reaction and intramolecular aldol reaction 
D)  Aldol reaction and intramolecular Claisen reaction

Question 11

What is the general name for the class of products formed in an Aldol condensation reaction?

Accepted Answer

A)  "F1F1F1S1F1F1F10,F1F1F1S1F1F1F10-unsaturated carbonyl compound" 
B)  "F1F1F1S1F1F1F10,F1F1F1S1F1F1F10-unsaturated carbonyl compound" 
C)  "F1F1F1S1F1F1F10,F1F1F1S1F1F1F10-unsaturated carbonyl compound" 
D)  "F1F1F1S1F1F1F10-hydroxy carbonyl compound" 
A)  "F1F1F1S1F1F1F10,F1F1F1S1F1F1F10-unsaturated carbonyl compound" 
B)  "F1F1F1S1F1F1F10,F1F1F1S1F1F1F10-unsaturated carbonyl compound" 
C)  "F1F1F1S1F1F1F10,F1F1F1S1F1F1F10-unsaturated carbonyl compound" 
D)  "F1F1F1S1F1F1F10-hydroxy carbonyl compound"

Question 12

What aldehyde or ketone is needed to prepare the following compound by an Aldol reaction?

Accepted Answer

A)  I 
B)  II 
C)  III 
D)  IV 
A)  I 
B)  II 
C)  III 
D)  IV

Question 13

What is the general name for the reaction product formed in a Claisen reaction?

Accepted Answer

A)  "F1F1F1S1F1F1F10-hydroxy ester" 
B)  "F1F1F1S1F1F1F10-keto ester" 
C)  "F1F1F1S1F1F1F10-keto ester" 
D)  "F1F1F1S1F1F1F10-hydroxy ester" 
A)  "F1F1F1S1F1F1F10-hydroxy ester" 
B)  "F1F1F1S1F1F1F10-keto ester" 
C)  "F1F1F1S1F1F1F10-keto ester" 
D)  "F1F1F1S1F1F1F10-hydroxy ester"

Question 14

What is the name given to the Claisen reaction between two different esters?

Accepted Answer

A)  multiple Claisen reaction 
B)  differential Claisen reaction 
C)  crossed Claisen reaction 
D)  versatile Claisen reaction 
A)  multiple Claisen reaction 
B)  differential Claisen reaction 
C)  crossed Claisen reaction 
D)  versatile Claisen reaction

Question 15

The F1F1F1S1F1F1F10-hydroxy carbonyl product of an Aldol reaction is oftentimes not the final isolated product, what is the explanation for this result?

Accepted Answer

A)  It undergoes elimination, since water is a good leaving group. 
B)  The hydroxy group is oxidized to a carbonyl. 
C)  The hydroxy group reacts with the carbonyl to form a ketal. 
D)  Hydroxide is eliminated via an enolate intermediate. 
A)  It undergoes elimination, since water is a good leaving group. 
B)  The hydroxy group is oxidized to a carbonyl. 
C)  The hydroxy group reacts with the carbonyl to form a ketal. 
D)  Hydroxide is eliminated via an enolate intermediate.

Question 16

Of the carbonyl compounds; (1) benzaldehyde, (2) acetophenone and (3) dicyclohexyl ketone, which compound has no F1F1F1S1F1F1F10-hydrogens?

Accepted Answer

A)  benzaldehyde 
B)  acetophenone 
C)  acetone 
D)  All of these compounds contain F1F1F1S1F1F1F10-hydrogens 
A)  benzaldehyde 
B)  acetophenone 
C)  acetone 
D)  All of these compounds contain F1F1F1S1F1F1F10-hydrogens

Question 17

What type of esters can undergo Claisen reactions?

Accepted Answer

A)  All esters can undergo Claisen reactions. 
B)  Only esters with two hydrogen atoms on the F1F1F1S1F1F1F10 carbon can undergo Claisen reactions. 
C)  Only esters with three hydrogen atoms on the F1F1F1S1F1F1F10 carbon can undergo Claisen reactions. 
D)  Only esters with two or three hydrogen atoms on the F1F1F1S1F1F1F10 carbon can undergo Claisen reactions. 
A)  All esters can undergo Claisen reactions. 
B)  Only esters with two hydrogen atoms on the F1F1F1S1F1F1F10 carbon can undergo Claisen reactions. 
C)  Only esters with three hydrogen atoms on the F1F1F1S1F1F1F10 carbon can undergo Claisen reactions. 
D)  Only esters with two or three hydrogen atoms on the F1F1F1S1F1F1F10 carbon can undergo Claisen reactions.

Question 18

What cyclic product is formed in the intramolecular Aldol condensation when the following compound is treated with aqueous NaOH?

Accepted Answer

A)  I 
B)  II 
C)  III 
D)  IV 
A)  I 
B)  II 
C)  III 
D)  IV

Question 19

What is an intramolecular Claisen reaction called?

Accepted Answer

A)  Michael reaction 
B)  Robinson reaction 
C)  Hoffman reaction 
D)  Dieckmann reaction 
A)  Michael reaction 
B)  Robinson reaction 
C)  Hoffman reaction 
D)  Dieckmann reaction

Question 20

What is the product of the following Claisen reaction?

Accepted Answer

A)  I 
B)  II 
C)  III 
D)  IV 
A)  I 
B)  II 
C)  III 
D)  IV

Exam 24: Carbonyl Condensation Reactions

Which of the following carbonyl compounds do not undergo Aldol addition reactions when treated with aqueous sodium hydroxide?

Which of the following compounds can undergo an Aldol with itself?

There are several variations of the Aldol reaction. Which of the following types of reactants leads to only one possible product with the Aldol condensation reaction?

What reaction type is a Claisen reaction?

What is the cyclic product formed in the intramolecular Aldol condensation when the following compound is treated with aqueous NaOH?

What is the product of the self-condensation of ethanal (acetaldehyde), shown below?

In the correct order, what are the three steps in the mechanism of an Aldol reaction?

What is the Aldol addition product formed from the reaction of acetone, (CH3)2CO, with itself?

Which is the unsaturated carbonyl compound formed in the dehydration of the following -hydroxy carbonyl compound?

What are the names for the two parts of the mechanism in a Robinson annulation?

What is the general name for the class of products formed in an Aldol condensation reaction?

What aldehyde or ketone is needed to prepare the following compound by an Aldol reaction?

What is the general name for the reaction product formed in a Claisen reaction?

What is the name given to the Claisen reaction between two different esters?

The -hydroxy carbonyl product of an Aldol reaction is oftentimes not the final isolated product, what is the explanation for this result?

Of the carbonyl compounds; (1) benzaldehyde, (2) acetophenone and (3) dicyclohexyl ketone, which compound has no -hydrogens?

What type of esters can undergo Claisen reactions?

What cyclic product is formed in the intramolecular Aldol condensation when the following compound is treated with aqueous NaOH?

What is an intramolecular Claisen reaction called?

What is the product of the following Claisen reaction?

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What is the Aldol addition product formed from the reaction of acetone, (CH₃)₂CO, with itself?