Question 1

All of the following are functions of immunoglobulins EXCEPT:

Accepted Answer

A)  neutralization of toxic substances 
B)  facilitating phagocytosis through opsonization 
C)  interacting with cytotoxic T cells to lyse viruses 
D)  combining with complement to destroy cellular antigens 
A)  neutralization of toxic substances 
B)  facilitating phagocytosis through opsonization 
C)  interacting with cytotoxic T cells to lyse viruses 
D)  combining with complement to destroy cellular antigens

Question 2

Which of the following is true of IgE?

Accepted Answer

A)  fixes complement 
B)  binds to mast cells 
C)  found on mucosal surfaces 
D)  participates in agglutination reactions 
A)  fixes complement 
B)  binds to mast cells 
C)  found on mucosal surfaces 
D)  participates in agglutination reactions

Question 3

The primary response is characterized by:

Accepted Answer

A)  naive B cells recognizing antigens 
B)  memory B cells recognizing antigens 
C)  the production of large amounts of IgG 
D)  a very short lag period 
E)  a long duration of high titer 
A)  naive B cells recognizing antigens 
B)  memory B cells recognizing antigens 
C)  the production of large amounts of IgG 
D)  a very short lag period 
E)  a long duration of high titer

Question 4

IgD is produced by:

Accepted Answer

A)  differential splicing of the RNA transcript 
B)  differential splicing of the DNA transcript 
C)  constant gene region rearrangement 
D)  immature B cells 
A)  differential splicing of the RNA transcript 
B)  differential splicing of the DNA transcript 
C)  constant gene region rearrangement 
D)  immature B cells

Question 5

What is the main function of IgD?

Accepted Answer

A)  It helps in class switching. 
B)  It is a primary response antibody. 
C)  It protects mucous membranes. 
D)  It offers protection to newborns. 
A)  It helps in class switching. 
B)  It is a primary response antibody. 
C)  It protects mucous membranes. 
D)  It offers protection to newborns.

Question 6

Which immunoglobulin appears in the highest titer in the secondary response?

Accepted Answer

A)  IgG 
B)  IgA 
C)  IgM 
D)  IgD 
A)  IgG 
B)  IgA 
C)  IgM 
D)  IgD

Question 7

All polymeric but not monomeric immunoglobulins are characterized by:

Accepted Answer

A)  a secretory component 
B)  an extra H-chain domain 
C)  a J chain 
D)  high carbohydrate content 
A)  a secretory component 
B)  an extra H-chain domain 
C)  a J chain 
D)  high carbohydrate content

Question 8

All of the following are true of IgA EXCEPT:

Accepted Answer

A)  It is found in secretions. 
B)  It fixes complement. 
C)  It is a monomer in serum. 
D)  It is important in oral immunizations. 
A)  It is found in secretions. 
B)  It fixes complement. 
C)  It is a monomer in serum. 
D)  It is important in oral immunizations.

Question 9

Which of the following immunoglobulins is found in only trace amounts in the serum?

Accepted Answer

A)  IgM 
B)  IgG 
C)  IgD 
D)  IgA 
A)  IgM 
B)  IgG 
C)  IgD 
D)  IgA

Question 10

Where on an antibody molecule does combination with antigen take place?

Accepted Answer

A)  variable region 
B)  constant region 
C)  hinge region 
D)  Fc region 
A)  variable region 
B)  constant region 
C)  hinge region 
D)  Fc region

Question 11

IgA in the secretions has a valence of:

Accepted Answer

A)  one 
B)  two 
C)  four 
D)  ten 
A)  one 
B)  two 
C)  four 
D)  ten

Question 12

The ability of an antibody to opsonize is located in which region?

Accepted Answer

A)  F(ab)'2 
B)  Fc 
C)  VL + VC 
D)  hypervariable regions 
A)  F(ab)'2 
B)  Fc 
C)  VL + VC 
D)  hypervariable regions

Question 13

When papain is used to cleave antibody molecules,what are the products?

Accepted Answer

A)  2 Fab and Fc 
B)  two L chains and two H chains 
C)  VL,CL,VH,and CH 
A)  2 Fab and Fc 
B)  two L chains and two H chains 
C)  VL,CL,VH,and CH

Question 14

A Fab fragment consists of:

Accepted Answer

A)  two heavy chains 
B)  two light chains 
C)  one light chain and one-half of a heavy chain 
D)  one light chain and an entire heavy chain 
A)  two heavy chains 
B)  two light chains 
C)  one light chain and one-half of a heavy chain 
D)  one light chain and an entire heavy chain

Question 15

Which is the main purpose of the secretory component that is part of IgA?

Accepted Answer

A)  transports across endothelial cells 
B)  combines with antigen 
C)  joins the two monomers 
D)  involved in class switching 
A)  transports across endothelial cells 
B)  combines with antigen 
C)  joins the two monomers 
D)  involved in class switching

Question 16

Which of the following pairings of immunoglobulin and a property are true?

Accepted Answer

A)  IgA: crosses the placenta 
B)  IgG: most abundant in serum 
C)  IgM: immunoglobulin produced by a T cell 
D)  IgE: major immunoglobulin of secondary response 
A)  IgA: crosses the placenta 
B)  IgG: most abundant in serum 
C)  IgM: immunoglobulin produced by a T cell 
D)  IgE: major immunoglobulin of secondary response

Question 17

Kappa or lambda light chains:

Accepted Answer

A)  are encoded on the same chromosome 
B)  associate with only one type of heavy chain at a time 
C)  can be expressed by the same B cell 
D)  are expressed by a pre-B cell 
A)  are encoded on the same chromosome 
B)  associate with only one type of heavy chain at a time 
C)  can be expressed by the same B cell 
D)  are expressed by a pre-B cell

Question 18

Which class makes up 70 to 80 percent of total serum immunoglobulins?

Accepted Answer

A)  IgA 
B)  IgG 
C)  IgM 
D)  IgE 
A)  IgA 
B)  IgG 
C)  IgM 
D)  IgE

Question 19

Which immunoglobulin can cross the placenta?

Accepted Answer

A)  IgM 
B)  IgE 
C)  IgA 
D)  IgG 
A)  IgM 
B)  IgE 
C)  IgA 
D)  IgG

Question 20

Which of the following is true of a secondary response to an antigen?

Accepted Answer

A)  Equal amounts of IgM and IgG are made. 
B)  IgG is increased 100 to 1000 times. 
C)  IgM is increased 100 fold. 
D)  The lag time is the same as the primary response. 
A)  Equal amounts of IgM and IgG are made. 
B)  IgG is increased 100 to 1000 times. 
C)  IgM is increased 100 fold. 
D)  The lag time is the same as the primary response.

Exam 4: Antibody Structure and Function

All of the following are functions of immunoglobulins EXCEPT:

Which of the following is true of IgE?

The primary response is characterized by:

IgD is produced by:

What is the main function of IgD?

Which immunoglobulin appears in the highest titer in the secondary response?

All polymeric but not monomeric immunoglobulins are characterized by:

All of the following are true of IgA EXCEPT:

Which of the following immunoglobulins is found in only trace amounts in the serum?

Where on an antibody molecule does combination with antigen take place?

IgA in the secretions has a valence of:

The ability of an antibody to opsonize is located in which region?

When papain is used to cleave antibody molecules,what are the products?

A Fab fragment consists of:

Which is the main purpose of the secretory component that is part of IgA?

Which of the following pairings of immunoglobulin and a property are true?

Kappa or lambda light chains:

Which class makes up 70 to 80 percent of total serum immunoglobulins?

Which immunoglobulin can cross the placenta?

Which of the following is true of a secondary response to an antigen?

Introduction and Natural Immunity

Lymphoid System

Nature of Antigens and Major Histocompatibility Complex

Cytokines

Complement System

Safety and Specimen Preparation

Precipitation Reactions

Agglutination

Labeled Immunoassays

Molecular Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Immunoproliferative Diseases

Immunodeficiency Disease

Transplantation Immunology

Tumor Immunology

Serologic and Molecular Detection of Bacterial Infections

Serologic and Molecular Detection of Bacterial Infections

Serology of Parasitic and Fungal Infections

Spirochete Diseases

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