Question 1

The Centers for Disease Control and Prevention recommends which two-tiered testing procedure for Lyme disease?

Accepted Answer

A)  Screening by IFA or EIA with positive or borderline result followed by Western blot for confirmation 
B)  Screening by IFA followed by EIA for confirmation 
C)  Screening by Western blot followed by PCR for confirmation 
D)  Screening by EIA followed by PCR for confirmation 
A)  Screening by IFA or EIA with positive or borderline result followed by Western blot for confirmation 
B)  Screening by IFA followed by EIA for confirmation 
C)  Screening by Western blot followed by PCR for confirmation 
D)  Screening by EIA followed by PCR for confirmation

Question 2

Tests for specific treponemal antibody include which of the following?

Accepted Answer

A)  VDRL 
B)  RPR 
C)  FTA-ABS 
D)  All of the above 
A)  VDRL 
B)  RPR 
C)  FTA-ABS 
D)  All of the above

Question 3

The RPR and VDRL tests differ from each other in which of the following ways?

Accepted Answer

A)  Method for reading or visualizing the reaction 
B)  Specificity of antibody detected 
C)  Specificity of antigen detected 
D)  Principle for detecting antigen-antibody complexes 
A)  Method for reading or visualizing the reaction 
B)  Specificity of antibody detected 
C)  Specificity of antigen detected 
D)  Principle for detecting antigen-antibody complexes

Question 4

Which of the following is a cause of a biological false-negative result in the nontreponemal tests for syphilis?

Accepted Answer

A)  Rotated too long 
B)  Rheumatoid arthritis 
C)  Secondary syphilis 
D)  Slow rotator speed 
A)  Rotated too long 
B)  Rheumatoid arthritis 
C)  Secondary syphilis 
D)  Slow rotator speed

Question 5

Laboratory results for a patient indicated a positive RPR and a negative FTA.The patient had no obvious sore,rash,or other symptoms.What is the most likely cause of these results?

Accepted Answer

A)  Primary syphilis 
B)  Secondary syphilis 
C)  Tertiary syphilis 
D)  Another disease, such as mononucleosis 
A)  Primary syphilis 
B)  Secondary syphilis 
C)  Tertiary syphilis 
D)  Another disease, such as mononucleosis

Question 6

Treponema pallidum and Borrelia burgdorferi can be distinguished from each other on the basis of which of the following?

Accepted Answer

A)  Only T pallidum has axial filaments. 
B)  Only B burgdorferi has an outer sheath. 
C)  Only B burgdorferi can be grown in the laboratory on artificial media. 
D)  Only T pallidum stimulates IgM production against the membrane proteins. 
A)  Only T pallidum has axial filaments. 
B)  Only B burgdorferi has an outer sheath. 
C)  Only B burgdorferi can be grown in the laboratory on artificial media. 
D)  Only T pallidum stimulates IgM production against the membrane proteins.

Question 7

The VDRL test on cerebrospinal fluid for neurosyphilis:

Accepted Answer

A)  is very specific. 
B)  is very sensitive. 
C)  does not require the use of a microscope. 
D)  uses a higher antigen volume than the serum test. 
A)  is very specific. 
B)  is very sensitive. 
C)  does not require the use of a microscope. 
D)  uses a higher antigen volume than the serum test.

Question 8

Which statement about late manifestations of Lyme disease is true?

Accepted Answer

A)  Treatment cannot reverse complications. 
B)  Both central and peripheral nervous systems may be affected. 
C)  Cardiac or neurological damage occurs in all cases. 
D)  Arthritis appears only in elderly patients. 
A)  Treatment cannot reverse complications. 
B)  Both central and peripheral nervous systems may be affected. 
C)  Cardiac or neurological damage occurs in all cases. 
D)  Arthritis appears only in elderly patients.

Question 9

A patient is diagnosed with syphilis.Which of the following laboratory tests can be used to monitor the effectiveness of therapy in this patient?

Accepted Answer

A)  RPR 
B)  TP-PA 
C)  C-reactive protein 
D)  Monospot test 
A)  RPR 
B)  TP-PA 
C)  C-reactive protein 
D)  Monospot test

Question 10

A laboratory test that is used to confirm syphilis and detects specific treponemal antibodies is:

Accepted Answer

A)  VDRL. 
B)  TP-PA. 
C)  RPR. 
D)  monospot. 
A)  VDRL. 
B)  TP-PA. 
C)  RPR. 
D)  monospot.

Question 11

A new technologist is busy one night and has to perform an RPR on a serum sample.He does not calibrate the needle delivering the antigen,and the needle is delivering a larger volume of antigen than it is supposed to.What kind of error can this produce?

Accepted Answer

A)  Laboratory-induced false negative resulting from postzone 
B)  Laboratory-induced false positive resulting from postzone 
C)  Biological false positive 
D)  Biological false negative 
A)  Laboratory-induced false negative resulting from postzone 
B)  Laboratory-induced false positive resulting from postzone 
C)  Biological false positive 
D)  Biological false negative

Question 12

Which statement regarding laboratory diagnosis of Borrelia miyamotoi infection is true?

Accepted Answer

A)  Well-established ELISA kits for B miyamotoi antibody that have been approved by the Food and Drug Administration are available. 
B)  The organism is routinely cultured from blood. 
C)  Antibody tests are not subject to cross-reactivity with Lyme antibody tests. 
D)  Polymerase chain reaction may become a valuable diagnostic tool. 
A)  Well-established ELISA kits for B miyamotoi antibody that have been approved by the Food and Drug Administration are available. 
B)  The organism is routinely cultured from blood. 
C)  Antibody tests are not subject to cross-reactivity with Lyme antibody tests. 
D)  Polymerase chain reaction may become a valuable diagnostic tool.

Question 13

The antibody known as reagin is:

Accepted Answer

A)  only present in the disease syphilis. 
B)  tested for using charcoal sensitized with cardiolipin. 
C)  found in all patients with primary syphilis. 
D)  antibody directed against IgG. 
A)  only present in the disease syphilis. 
B)  tested for using charcoal sensitized with cardiolipin. 
C)  found in all patients with primary syphilis. 
D)  antibody directed against IgG.

Question 14

Which of the following is a cause of a biological false-positive in the nontreponemal assays for syphilis?

Accepted Answer

A)  Prozone 
B)  Reagents too cold 
C)  Sera dried on card 
D)  Autoimmune disease 
A)  Prozone 
B)  Reagents too cold 
C)  Sera dried on card 
D)  Autoimmune disease

Question 15

Patient serum is mixed with gel particles that have been sensitized with Treponema pallidum antigens as well as with unsensitized gel particles in a separate well.Agglutination was observed in the well with sensitized gel particles but not in the well with unsensitized gel particles.What is the interpretation of these results?

Accepted Answer

A)  Positive for anti-T pallidum antibodies 
B)  Positive for heterophile antibodies 
C)  Negative for anti-T pallidum antibodies 
D)  Negative for anticardiolipin antibodies 
A)  Positive for anti-T pallidum antibodies 
B)  Positive for heterophile antibodies 
C)  Negative for anti-T pallidum antibodies 
D)  Negative for anticardiolipin antibodies

Question 16

A patient presents with personality changes,altered mental state,and delusions of grandeur.The patient is then diagnosed as having syphilis.The patient is most likely in which stage of syphilis?

Accepted Answer

A)  Primary 
B)  Secondary 
C)  Latent 
D)  Tertiary 
A)  Primary 
B)  Secondary 
C)  Latent 
D)  Tertiary

The Centers for Disease Control and Prevention recommends which two-tiered testing procedure for Lyme disease?

Tests for specific treponemal antibody include which of the following?

The RPR and VDRL tests differ from each other in which of the following ways?

Which of the following is a cause of a biological false-negative result in the nontreponemal tests for syphilis?

Laboratory results for a patient indicated a positive RPR and a negative FTA.The patient had no obvious sore,rash,or other symptoms.What is the most likely cause of these results?

Treponema pallidum and Borrelia burgdorferi can be distinguished from each other on the basis of which of the following?

The VDRL test on cerebrospinal fluid for neurosyphilis:

Which statement about late manifestations of Lyme disease is true?

A patient is diagnosed with syphilis.Which of the following laboratory tests can be used to monitor the effectiveness of therapy in this patient?

A laboratory test that is used to confirm syphilis and detects specific treponemal antibodies is:

A new technologist is busy one night and has to perform an RPR on a serum sample.He does not calibrate the needle delivering the antigen,and the needle is delivering a larger volume of antigen than it is supposed to.What kind of error can this produce?

Which statement regarding laboratory diagnosis of Borrelia miyamotoi infection is true?

The antibody known as reagin is:

Which of the following is a cause of a biological false-positive in the nontreponemal assays for syphilis?

A patient presents with personality changes,altered mental state,and delusions of grandeur.The patient is then diagnosed as having syphilis.The patient is most likely in which stage of syphilis?

Introduction to Immunity and the Immune System

Nature of Antigens and the Major Histocompatibility Complex

Innate Immunity

Adaptive Immunity

Antibody Structure and Function

Cytokines

Complement System

Safety and Quality Management

Principles of Serological Testing

Precipitation and Agglutination Reactions

Labeled Immunoassays

Molecular Diagnostic Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Transplantation Immunology

Tumor Immunology

Immunoproliferative Diseases

Immunodeficiency Diseases

Serological and Molecular Detection of Bacterial Infections

Serological and Molecular Diagnosis of Parasitic and Fungal Infections

Serology and Molecular Detection of Viral Infections

Laboratory Diagnosis of HIV Infection

Immunization and Vaccines

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Exam 21: Spirochete Diseases

The Centers for Disease Control and Prevention recommends which two-tiered testing procedure for Lyme disease?

Tests for specific treponemal antibody include which of the following?

The RPR and VDRL tests differ from each other in which of the following ways?

Which of the following is a cause of a biological false-negative result in the nontreponemal tests for syphilis?

Laboratory results for a patient indicated a positive RPR and a negative FTA.The patient had no obvious sore,rash,or other symptoms.What is the most likely cause of these results?

Treponema pallidum and Borrelia burgdorferi can be distinguished from each other on the basis of which of the following?

The VDRL test on cerebrospinal fluid for neurosyphilis:

Which statement about late manifestations of Lyme disease is true?

A patient is diagnosed with syphilis.Which of the following laboratory tests can be used to monitor the effectiveness of therapy in this patient?

A laboratory test that is used to confirm syphilis and detects specific treponemal antibodies is:

A new technologist is busy one night and has to perform an RPR on a serum sample.He does not calibrate the needle delivering the antigen,and the needle is delivering a larger volume of antigen than it is supposed to.What kind of error can this produce?

Which statement regarding laboratory diagnosis of Borrelia miyamotoi infection is true?

The antibody known as reagin is:

Which of the following is a cause of a biological false-positive in the nontreponemal assays for syphilis?

A patient presents with personality changes,altered mental state,and delusions of grandeur.The patient is then diagnosed as having syphilis.The patient is most likely in which stage of syphilis?

Introduction to Immunity and the Immune System

Nature of Antigens and the Major Histocompatibility Complex

Innate Immunity

Adaptive Immunity

Antibody Structure and Function

Cytokines

Complement System

Safety and Quality Management

Principles of Serological Testing

Precipitation and Agglutination Reactions

Labeled Immunoassays

Molecular Diagnostic Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Transplantation Immunology

Tumor Immunology

Immunoproliferative Diseases

Immunodeficiency Diseases

Serological and Molecular Detection of Bacterial Infections

Serological and Molecular Diagnosis of Parasitic and Fungal Infections

Serology and Molecular Detection of Viral Infections

Laboratory Diagnosis of HIV Infection

Immunization and Vaccines

Filters