Question 1

A patient with hereditary angioedema will present with swelling in the tissues and has deficiencies in which of the following?

Accepted Answer

A)  C5, C6, C7, C8 
B)  Phagocytic cell function 
C)  Mature B cells 
D)  C1 inhibitor 
A)  C5, C6, C7, C8 
B)  Phagocytic cell function 
C)  Mature B cells 
D)  C1 inhibitor

Question 2

A specific defect in innate immunity leading to bacterial infections could involve a deficiency in:

Accepted Answer

A)  T-cell receptors. 
B)  B-cell receptors. 
C)  toll-like receptors. 
D)  MHC class I. 
A)  T-cell receptors. 
B)  B-cell receptors. 
C)  toll-like receptors. 
D)  MHC class I.

Question 3

An inflammatory syndrome involving recurrent fevers is

Accepted Answer

A)  ataxia telangiectasia. 
B)  Wiskott-Aldrich. 
C)  autoimmune lymphoproliferative. 
D)  hyper IgD. 
A)  ataxia telangiectasia. 
B)  Wiskott-Aldrich. 
C)  autoimmune lymphoproliferative. 
D)  hyper IgD.

Question 4

Which of the following is associated with DiGeorge syndrome?

Accepted Answer

A)  Small or missing thymus 
B)  Missing B-cell precursors 
C)  Inherited as X-linked recessive 
D)  M spike in the gamma region 
A)  Small or missing thymus 
B)  Missing B-cell precursors 
C)  Inherited as X-linked recessive 
D)  M spike in the gamma region

Question 5

Delayed-type hypersensitivity skin tests are used to screen for:

Accepted Answer

A)  humoral immunodeficiencies. 
B)  cell-mediated immunodeficiencies. 
C)  phagocyte immunodeficiencies. 
D)  complement deficiencies. 
A)  humoral immunodeficiencies. 
B)  cell-mediated immunodeficiencies. 
C)  phagocyte immunodeficiencies. 
D)  complement deficiencies.

Question 6

The most common complement component deficiency is:

Accepted Answer

A)  C1q. 
B)  factor B. 
C)  MASP. 
D)  C2. 
A)  C1q. 
B)  factor B. 
C)  MASP. 
D)  C2.

Question 7

Decreased CD3-positive lymphocytes and a lack of responsiveness to phytohemagglutinin in the circulation are typically associated with:

Accepted Answer

A)  inflammation. 
B)  transient hypogammaglobulinemia. 
C)  DiGeorge anomaly. 
D)  chronic granulomatous disease. 
A)  inflammation. 
B)  transient hypogammaglobulinemia. 
C)  DiGeorge anomaly. 
D)  chronic granulomatous disease.

Question 8

The most common form of severe combined immunodeficiency disease results from an X-linked mutation in the gene that codes for:

Accepted Answer

A)  interleukin-2. 
B)  a receptor subunit involved in signaling for interleukins-2, -4, -7, and -9. 
C)  a common subunit involved in signaling for the B-cell receptor and T-cell receptor complexes. 
D)  a sequence common to CD3 and CD19. 
A)  interleukin-2. 
B)  a receptor subunit involved in signaling for interleukins-2, -4, -7, and -9. 
C)  a common subunit involved in signaling for the B-cell receptor and T-cell receptor complexes. 
D)  a sequence common to CD3 and CD19.

Question 9

A 2-week-old girl is evaluated by a specialist because her physical appearance is abnormal.She has been hospitalized since birth.Her CD3 level is reported as 15% (normal values: 60%-80%).Her CD4 is 10% (normal values: 30%-65%).Her CD8 is 5% (normal values: 10%-40%),and her CD19 is 84% (normal values: 5%-20%).Serum immunoglobulin levels are normal.Karyotyping reveals a deletion on chromosome 22.These laboratory results support a diagnosis of:

Accepted Answer

A)  Bruton's tyrosine kinase deficiency. 
B)  Wiskott-Aldrich syndrome. 
C)  DiGeorge anomaly. 
D)  ataxia telangiectasia. 
A)  Bruton's tyrosine kinase deficiency. 
B)  Wiskott-Aldrich syndrome. 
C)  DiGeorge anomaly. 
D)  ataxia telangiectasia.

Question 10

A nitroblue tetrazolium test shows little color in cells observed under a microscope.What disease does this finding correlate with?

Accepted Answer

A)  Chronic granulomatous disease 
B)  Ataxia telangiectasia 
C)  Wiskott-Aldrich syndrome 
D)  Transient hypogammaglobulinemia 
A)  Chronic granulomatous disease 
B)  Ataxia telangiectasia 
C)  Wiskott-Aldrich syndrome 
D)  Transient hypogammaglobulinemia

Question 11

Which syndrome is characterized by defective apoptosis,leading to survival of lymphocytes that can react with self antigens?

Accepted Answer

A)  Ataxia telangiectasia 
B)  Wiskott-Aldrich 
C)  Autoimmune lymphoproliferative 
D)  Chediak-Higashi 
A)  Ataxia telangiectasia 
B)  Wiskott-Aldrich 
C)  Autoimmune lymphoproliferative 
D)  Chediak-Higashi

Question 12

Which enzyme deficiency causes moderate to severe impairment of cell-mediated immunity,with little or no effect on humoral immunity?

Accepted Answer

A)  Recombinase activating gene 1 or 2 
B)  Purine-nucleoside phosphorylase 
C)  Mevalonate kinase 
D)  Adenosine deaminase 
A)  Recombinase activating gene 1 or 2 
B)  Purine-nucleoside phosphorylase 
C)  Mevalonate kinase 
D)  Adenosine deaminase

Question 13

Which of the following statements about severe combined immunodeficiency is true?

Accepted Answer

A)  It may be associated with a signal transduction defect. 
B)  It is accompanied by hypergammaglobulinemia. 
C)  Patients can be vaccinated with live virus. 
D)  It occurs only in males. 
A)  It may be associated with a signal transduction defect. 
B)  It is accompanied by hypergammaglobulinemia. 
C)  Patients can be vaccinated with live virus. 
D)  It occurs only in males.

A patient with hereditary angioedema will present with swelling in the tissues and has deficiencies in which of the following?

A specific defect in innate immunity leading to bacterial infections could involve a deficiency in:

An inflammatory syndrome involving recurrent fevers is

Which of the following is associated with DiGeorge syndrome?

Delayed-type hypersensitivity skin tests are used to screen for:

The most common complement component deficiency is:

Decreased CD3-positive lymphocytes and a lack of responsiveness to phytohemagglutinin in the circulation are typically associated with:

The most common form of severe combined immunodeficiency disease results from an X-linked mutation in the gene that codes for:

A nitroblue tetrazolium test shows little color in cells observed under a microscope.What disease does this finding correlate with?

Which syndrome is characterized by defective apoptosis,leading to survival of lymphocytes that can react with self antigens?

Which enzyme deficiency causes moderate to severe impairment of cell-mediated immunity,with little or no effect on humoral immunity?

Which of the following statements about severe combined immunodeficiency is true?

Introduction to Immunity and the Immune System

Nature of Antigens and the Major Histocompatibility Complex

Innate Immunity

Adaptive Immunity

Antibody Structure and Function

Cytokines

Complement System

Safety and Quality Management

Principles of Serological Testing

Precipitation and Agglutination Reactions

Labeled Immunoassays

Molecular Diagnostic Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Transplantation Immunology

Tumor Immunology

Immunoproliferative Diseases

Serological and Molecular Detection of Bacterial Infections

Spirochete Diseases

Serological and Molecular Diagnosis of Parasitic and Fungal Infections

Serology and Molecular Detection of Viral Infections

Laboratory Diagnosis of HIV Infection

Immunization and Vaccines

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Exam 19: Immunodeficiency Diseases

A patient with hereditary angioedema will present with swelling in the tissues and has deficiencies in which of the following?

A specific defect in innate immunity leading to bacterial infections could involve a deficiency in:

An inflammatory syndrome involving recurrent fevers is

Which of the following is associated with DiGeorge syndrome?

Delayed-type hypersensitivity skin tests are used to screen for:

The most common complement component deficiency is:

Decreased CD3-positive lymphocytes and a lack of responsiveness to phytohemagglutinin in the circulation are typically associated with:

The most common form of severe combined immunodeficiency disease results from an X-linked mutation in the gene that codes for:

A nitroblue tetrazolium test shows little color in cells observed under a microscope.What disease does this finding correlate with?

Which syndrome is characterized by defective apoptosis,leading to survival of lymphocytes that can react with self antigens?

Which enzyme deficiency causes moderate to severe impairment of cell-mediated immunity,with little or no effect on humoral immunity?

Which of the following statements about severe combined immunodeficiency is true?

Introduction to Immunity and the Immune System

Nature of Antigens and the Major Histocompatibility Complex

Innate Immunity

Adaptive Immunity

Antibody Structure and Function

Cytokines

Complement System

Safety and Quality Management

Principles of Serological Testing

Precipitation and Agglutination Reactions

Labeled Immunoassays

Molecular Diagnostic Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Transplantation Immunology

Tumor Immunology

Immunoproliferative Diseases

Serological and Molecular Detection of Bacterial Infections

Spirochete Diseases

Serological and Molecular Diagnosis of Parasitic and Fungal Infections

Serology and Molecular Detection of Viral Infections

Laboratory Diagnosis of HIV Infection

Immunization and Vaccines

Filters