Exam 15: Autoimmunity

The fluorescent antinuclear antibody test for lupus is an example of which of the following?

Antibodies directed against thyroglobulin represent a significant finding in which of the following autoimmune diseases?

A 40-year-old female patient has increased thyroid-stimulating hormone (TSH)and decreased T4 levels with a normal T3 level.Antithyroglobulin is measured as 1:1280,and the antimicrosomal level is reportedly 1:6400.This patient most likely has:

A 25-year-old female sees her physician because of swelling in the joints of her hands and generally feeling tired and rundown.A slide agglutination test for antibody directed against IgG is positive.What is the most likely cause of her symptoms?

A 40-year-old woman presents with a lemon-yellow,waxy pallor and a red,beefy tongue.She is extremely fatigued and is having difficulty getting up in the morning and getting through the day.Antiparietal cell antibodies are found in her serum.This woman most likely has:

Antibodies to cyclic citrullinated proteins (anti-CCP)are specific diagnostic indicators for:

A 35-year-old female experiences difficulty in walking,and her hands and feet are numb from time to time.Suspecting a disease involving the central nervous system,her physician orders magnetic resonance imaging (MRI).The MRI reveals lesions on the myelin sheath.What is the most likely disease?

Homogeneous staining of the nucleus in an antinuclear antibody test indicates:

In the rheumatoid factor test,what is being detected?

Autoimmune hemolytic anemia targets which cells or tissues?

A 30-year-old clinical laboratory science student complains of being tired but is not able to sleep.The woman also states that her hair has been breaking off,and she has lost 20 pounds over the past 2 months without trying.The woman's pulse and blood pressure are elevated,and her eyes seem to be bulging.Her complete blood count (CBC)is normal,thyroid-stimulating hormone is decreased,and T4 is increased.Antimicrosomal and antithyroglobulin antibodies are each 1:400.This woman most likely has:

A disease characterized by hypoactivity of the thyroid with weight gain and a sluggish metabolism as a result of destruction of thyroglobulin best describes:

An autoimmune disease characterized by pain and progressive destruction of the joints,weight loss,morning stiffness,and presence of an antibody directed against IgG best describes:

Citrullinated proteins:

A 45-year-old male presents to his physician complaining of achy joints,chronic runny nose,and coughing up blood.Chest x-ray shows pulmonary infiltrates.Cortisol is increased; erythrocyte sedimentation rate (ESR)is slightly elevated.Tests for autoantibodies are positive for antineutrophil cytoplasmic antibodies.On the basis of these findings,a likely diagnosis for this patient is: