Question 1

Select the statement that best describes the action of IL-1.

Accepted Answer

A)  Increases synthesis of acute-phase reactants 
B)  Increases proliferation of Th2 cells. 
C)  Increases production of IgE 
D)  Inhibits antigen presentation by macrophages 
A)  Increases synthesis of acute-phase reactants 
B)  Increases proliferation of Th2 cells. 
C)  Increases production of IgE 
D)  Inhibits antigen presentation by macrophages

Question 2

A person steps on a rusty nail,which punctures her skin and activates resident macrophages to secrete IL-1 beta.The fever that develops is an example of what type of cytokine signaling?

Accepted Answer

A)  Autocrine 
B)  Paracrine 
C)  Endocrine 
D)  Kallikrein 
A)  Autocrine 
B)  Paracrine 
C)  Endocrine 
D)  Kallikrein

Question 3

Which clinical assay can be used for measuring cytokine concentrations in serum samples?

Accepted Answer

A)  Microbead assay 
B)  Polymerase chain reaction 
C)  ELISpot 
D)  Flow cytometry 
A)  Microbead assay 
B)  Polymerase chain reaction 
C)  ELISpot 
D)  Flow cytometry

Question 4

Which cytokine is involved in natural immunity?

Accepted Answer

A)  IL-2 
B)  IL-4 
C)  IL-5 
D)  IL-6 
A)  IL-2 
B)  IL-4 
C)  IL-5 
D)  IL-6

Question 5

What is one of the main activities of IL-4?

Accepted Answer

A)  Downregulates the immune response 
B)  Increases production of neutrophils 
C)  Generates Th2 cells 
D)  Protects cells from viral invasion 
A)  Downregulates the immune response 
B)  Increases production of neutrophils 
C)  Generates Th2 cells 
D)  Protects cells from viral invasion

Question 6

Erythropoietin regulates:

Accepted Answer

A)  T-cell function. 
B)  bone marrow cell differentiation. 
C)  proinflammatory cytokine synthesis. 
D)  the acute-phase response. 
A)  T-cell function. 
B)  bone marrow cell differentiation. 
C)  proinflammatory cytokine synthesis. 
D)  the acute-phase response.

Question 7

Characteristic of cytokines include which of the following?

Accepted Answer

A)  They are directly cytotoxic to bacteria. 
B)  They are produced primarily by the liver. 
C)  They are chemical messengers that regulate the immune system. 
D)  They are polysaccharides. 
A)  They are directly cytotoxic to bacteria. 
B)  They are produced primarily by the liver. 
C)  They are chemical messengers that regulate the immune system. 
D)  They are polysaccharides.

Question 8

Multiple cytokines are activated to cause similar biological effects.What is this process called?

Accepted Answer

A)  Pleiotropy 
B)  Redundancy 
C)  Synergism 
D)  Antagonism 
A)  Pleiotropy 
B)  Redundancy 
C)  Synergism 
D)  Antagonism

Question 9

The main target of IL-3 is:

Accepted Answer

A)  antigen-activated B cells. 
B)  antigen-activated T cells. 
C)  macrophages. 
D)  stem cells. 
A)  antigen-activated B cells. 
B)  antigen-activated T cells. 
C)  macrophages. 
D)  stem cells.

Question 10

IL-3,IL-5,and several colony-stimulating factors all use a common subunit in their receptors.As a result,you would expect that they have what kind of actions?

Accepted Answer

A)  Pleiotropic 
B)  Redundant 
C)  Autocrine 
D)  Paracrine 
A)  Pleiotropic 
B)  Redundant 
C)  Autocrine 
D)  Paracrine

Question 11

Which cytokine might be given therapeutically to a patient with severe anemia?

Accepted Answer

A)  IL-4 
B)  Erythropoietin 
C)  TGF-beta 
D)  Interferon-alpha 
A)  IL-4 
B)  Erythropoietin 
C)  TGF-beta 
D)  Interferon-alpha

Question 12

Which of the following would be an effective therapy for rheumatoid arthritis?

Accepted Answer

A)  TNF 
B)  IL-6 
C)  Antibodies against TNF receptors 
D)  Antibodies against IL-2 
A)  TNF 
B)  IL-6 
C)  Antibodies against TNF receptors 
D)  Antibodies against IL-2

Question 13

What is the function of TGF-beta?

Accepted Answer

A)  Promotes cell-mediated immunity 
B)  Regulates cell growth and differentiation 
C)  Inhibits IL-2 
D)  Acts as an endogenous pyrogen 
A)  Promotes cell-mediated immunity 
B)  Regulates cell growth and differentiation 
C)  Inhibits IL-2 
D)  Acts as an endogenous pyrogen

Question 14

IL-2 is synthesized by:

Accepted Answer

A)  T cells. 
B)  B cells. 
C)  Monocytes. 
D)  Mast cells. 
A)  T cells. 
B)  B cells. 
C)  Monocytes. 
D)  Mast cells.

Question 15

IL-3,IL-7,and GM-CSF are all involved in:

Accepted Answer

A)  hematopoiesis. 
B)  suppressing inflammation. 
C)  macrophage killing. 
D)  T-cell cytotoxicity. 
A)  hematopoiesis. 
B)  suppressing inflammation. 
C)  macrophage killing. 
D)  T-cell cytotoxicity.

Select the statement that best describes the action of IL-1.

A person steps on a rusty nail,which punctures her skin and activates resident macrophages to secrete IL-1 beta.The fever that develops is an example of what type of cytokine signaling?

Which clinical assay can be used for measuring cytokine concentrations in serum samples?

Which cytokine is involved in natural immunity?

What is one of the main activities of IL-4?

Erythropoietin regulates:

Characteristic of cytokines include which of the following?

Multiple cytokines are activated to cause similar biological effects.What is this process called?

The main target of IL-3 is:

IL-3,IL-5,and several colony-stimulating factors all use a common subunit in their receptors.As a result,you would expect that they have what kind of actions?

Which cytokine might be given therapeutically to a patient with severe anemia?

Which of the following would be an effective therapy for rheumatoid arthritis?

What is the function of TGF-beta?

IL-2 is synthesized by:

IL-3,IL-7,and GM-CSF are all involved in:

Introduction to Immunity and the Immune System

Nature of Antigens and the Major Histocompatibility Complex

Innate Immunity

Adaptive Immunity

Antibody Structure and Function

Complement System

Safety and Quality Management

Principles of Serological Testing

Precipitation and Agglutination Reactions

Labeled Immunoassays

Molecular Diagnostic Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Transplantation Immunology

Tumor Immunology

Immunoproliferative Diseases

Immunodeficiency Diseases

Serological and Molecular Detection of Bacterial Infections

Spirochete Diseases

Serological and Molecular Diagnosis of Parasitic and Fungal Infections

Serology and Molecular Detection of Viral Infections

Laboratory Diagnosis of HIV Infection

Immunization and Vaccines

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Exam 6: Cytokines

Select the statement that best describes the action of IL-1.

A person steps on a rusty nail,which punctures her skin and activates resident macrophages to secrete IL-1 beta.The fever that develops is an example of what type of cytokine signaling?

Which clinical assay can be used for measuring cytokine concentrations in serum samples?

Which cytokine is involved in natural immunity?

What is one of the main activities of IL-4?

Erythropoietin regulates:

Characteristic of cytokines include which of the following?

Multiple cytokines are activated to cause similar biological effects.What is this process called?

The main target of IL-3 is:

IL-3,IL-5,and several colony-stimulating factors all use a common subunit in their receptors.As a result,you would expect that they have what kind of actions?

Which cytokine might be given therapeutically to a patient with severe anemia?

Which of the following would be an effective therapy for rheumatoid arthritis?

What is the function of TGF-beta?

IL-2 is synthesized by:

IL-3,IL-7,and GM-CSF are all involved in:

Introduction to Immunity and the Immune System

Nature of Antigens and the Major Histocompatibility Complex

Innate Immunity

Adaptive Immunity

Antibody Structure and Function

Complement System

Safety and Quality Management

Principles of Serological Testing

Precipitation and Agglutination Reactions

Labeled Immunoassays

Molecular Diagnostic Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Transplantation Immunology

Tumor Immunology

Immunoproliferative Diseases

Immunodeficiency Diseases

Serological and Molecular Detection of Bacterial Infections

Spirochete Diseases

Serological and Molecular Diagnosis of Parasitic and Fungal Infections

Serology and Molecular Detection of Viral Infections

Laboratory Diagnosis of HIV Infection

Immunization and Vaccines

Filters