Question 1

Common alleles of genes other than BRCA1 ____.

Accepted Answer

A)  dictate the types of mutations that occur in BRCA2 
B)  cause uncontrolled division of the BRCA2 gene 
C)  cause the interruption of the cell cycle in any cell containing a BRCA2 mutation 
D)  have a strong influence on whether a carrier will develop breast cancer 
E)  have very little influence on whether a carrier will develop breast cancer 
A)  dictate the types of mutations that occur in BRCA2 
B)  cause uncontrolled division of the BRCA2 gene 
C)  cause the interruption of the cell cycle in any cell containing a BRCA2 mutation 
D)  have a strong influence on whether a carrier will develop breast cancer 
E)  have very little influence on whether a carrier will develop breast cancer

Question 2

Leukemia is a type of cancer that involves the uncontrolled division of ____________________ cells.

Accepted Answer

The answer of Leukemia is a type of cancer that...

Question 3

In rapidly dividing cells,expression of BRCA1 and BRCA2 genes is the highest during the ____.

Accepted Answer

A)  mitosis to cytokinesis transition 
B)  G1/S transition and into S phase 
C)  G2/mitosis transition 
D)  S/G2 transition 
E)  metaphase to anaphase transition 
A)  mitosis to cytokinesis transition 
B)  G1/S transition and into S phase 
C)  G2/mitosis transition 
D)  S/G2 transition 
E)  metaphase to anaphase transition

Question 4

Genes that turn off or decrease the rate of cell division are known as ____________________ genes.

Accepted Answer

The answer of Genes that turn off or decrease the...

Question 5

Summarize two pathways to colon cancer.

Accepted Answer

The first pathway to FAP colon cancer be

Question 6

Progressive chromosomal changes as cancer develops are related to the loss of the ability to repair ____________________ in cancer cells.

Accepted Answer

DNA damage

Question 7

Stem cells have the ability to differentiate to form specific cell types,which divide only slowly or not at all.

Accepted Answer

A) True 
 B)False

Question 8

Hereditary nonpolyposis colon cancers (HNPCC)____.

Accepted Answer

A)  are rare in the United States, but common in Europe 
B)  begin with a mutation in the APC gene 
C)  are caused by one-of-a-kind DNA sequences called microsatellites 
D)  are caused by one mutation in a single gene 
E)  are caused by several mutations in several different genes 
A)  are rare in the United States, but common in Europe 
B)  begin with a mutation in the APC gene 
C)  are caused by one-of-a-kind DNA sequences called microsatellites 
D)  are caused by one mutation in a single gene 
E)  are caused by several mutations in several different genes

Question 9

Give a possible interpretation of the finding that the number of mutational events that occur during the transition from normal to malignant cells is much larger than previously thought.

Accepted Answer

It has always been assumed that the proc

Question 10

Most of the somatic cells in the body are structurally and functionally specialized and do not divide.

Accepted Answer

A) True 
 B)False

Question 11

If a cell begins to divide in an uncontrolled way,it ____.

Accepted Answer

A)  will always form a cancerous tumor 
B)  may form a benign tumor 
C)  is a sign of metastasis 
D)  is considered a malignant tumor 
E)  signals uncontrolled cell division in other parts of the body 
A)  will always form a cancerous tumor 
B)  may form a benign tumor 
C)  is a sign of metastasis 
D)  is considered a malignant tumor 
E)  signals uncontrolled cell division in other parts of the body

Question 12

List four lines of evidence that support a link between cancer and genetics.Describe the ultimate cause of cancer and how an individual's life-style might reduce the chances of developing cancer.

Accepted Answer

The link between cancer and genetics is

Question 13

Explain why epithelial cells are the source of 80% to 90% of all cancers.Then list at least two types of epithelial cells,and at least four types of cancer for which they are the source.

Accepted Answer

Epithelial cells divide more or less con

Question 14

Stem cells ____.

Accepted Answer

A)  have the property of self-renewal by division 
B)  are the least likely to give rise to cancer 
C)  do not have the ability to divide 
D)  are immature cells that become nerve tissue susceptible to cancer 
E)  are found only in cancerous tumors 
A)  have the property of self-renewal by division 
B)  are the least likely to give rise to cancer 
C)  do not have the ability to divide 
D)  are immature cells that become nerve tissue susceptible to cancer 
E)  are found only in cancerous tumors

Question 15

Explain how the loss of heterozygosity (LOH)leads a cell to become cancerous.

Accepted Answer

An individual in a heterozygous conditio

Question 16

The RB1 tumor-suppressor gene ____.

Accepted Answer

A)  controls the G2/M checkpoint 
B)  controls the G1/S checkpoint 
C)  is overactive in cases of retinoblastoma 
D)  is overactive in cases of breast cancer 
E)  is overactive in cases of leukemia 
A)  controls the G2/M checkpoint 
B)  controls the G1/S checkpoint 
C)  is overactive in cases of retinoblastoma 
D)  is overactive in cases of breast cancer 
E)  is overactive in cases of leukemia

Question 17

A reciprocal translocation between two chromosomes can result in the formation of a(n)____________________ gene.

Accepted Answer

The answer of A reciprocal translocation between two chromosomes can...

Question 18

When MSH2 and MLH1 are inactivated by mutation,DNA repair is defective and ____________________ mutation rates increase by at least 100-fold.

Accepted Answer

The answer of When MSH2 and MLH1 are inactivated by...

Question 19

The field of epigenetics has opened the way for the development of a new class of anticancer drugs ____.

Accepted Answer

A)  that are very similar to many chemotherapy treatments but are much more targeted and effective 
B)  that stop mutations before they occur in individuals with a predisposition to certain kinds of cancer 
C)  that increase the level of methylation in cancer cells 
D)  used specifically to treat breast cancer because the key genes involved in this cancer cannot be epigenetically modified 
E)  because of the discovery that epigenetic modification of key genes is important in some cancers and the fact that epigenetic changes are reversible 
A)  that are very similar to many chemotherapy treatments but are much more targeted and effective 
B)  that stop mutations before they occur in individuals with a predisposition to certain kinds of cancer 
C)  that increase the level of methylation in cancer cells 
D)  used specifically to treat breast cancer because the key genes involved in this cancer cannot be epigenetically modified 
E)  because of the discovery that epigenetic modification of key genes is important in some cancers and the fact that epigenetic changes are reversible

Question 20

Hereditary nonpolyposis colon cancer (HNPCC)requires only one mutational step to initiate the formation of a cancer cell.

Accepted Answer

A) True 
 B)False

Common alleles of genes other than BRCA1 ____.

Leukemia is a type of cancer that involves the uncontrolled division of ____________________ cells.

In rapidly dividing cells,expression of BRCA1 and BRCA2 genes is the highest during the ____.

Genes that turn off or decrease the rate of cell division are known as ____________________ genes.

Summarize two pathways to colon cancer.

Progressive chromosomal changes as cancer develops are related to the loss of the ability to repair ____________________ in cancer cells.

Stem cells have the ability to differentiate to form specific cell types,which divide only slowly or not at all.

Hereditary nonpolyposis colon cancers (HNPCC)____.

Give a possible interpretation of the finding that the number of mutational events that occur during the transition from normal to malignant cells is much larger than previously thought.

Most of the somatic cells in the body are structurally and functionally specialized and do not divide.

If a cell begins to divide in an uncontrolled way,it ____.

List four lines of evidence that support a link between cancer and genetics.Describe the ultimate cause of cancer and how an individual's life-style might reduce the chances of developing cancer.

Explain why epithelial cells are the source of 80% to 90% of all cancers.Then list at least two types of epithelial cells,and at least four types of cancer for which they are the source.

Stem cells ____.

Explain how the loss of heterozygosity (LOH)leads a cell to become cancerous.

The RB1 tumor-suppressor gene ____.

A reciprocal translocation between two chromosomes can result in the formation of a(n)____________________ gene.

When MSH2 and MLH1 are inactivated by mutation,DNA repair is defective and ____________________ mutation rates increase by at least 100-fold.

The field of epigenetics has opened the way for the development of a new class of anticancer drugs ____.

Hereditary nonpolyposis colon cancer (HNPCC)requires only one mutational step to initiate the formation of a cancer cell.

A Perspective on Human Genetics

Cells and Cell Division

Transmission of Genes from Generation to Generation

Pedigree Analysis in Human Genetics

The Inheritance of Complex Traits

Cytogenetics - Karyotypes and Chromosome Aberrations

Development and Sex Determination

The Structure - Replication - and Chromosomal Organization of DNA

Gene Expression and Gene Regulation

From Proteins to Phenotypes

Genome Alterations - Mutation and Epigenetics

An Introduction to Genetic Technology

Biotechnology and Society

Genomes and Genomics

Reproductive Technology - Genetic Testing - and Gene Therapy

Genes and The Immune System

Genetics of Behavior

Population Genetics and Human Evolution

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Exam 12: Genes and Cancer

Common alleles of genes other than BRCA1 ____.

Leukemia is a type of cancer that involves the uncontrolled division of ____________________ cells.

In rapidly dividing cells,expression of BRCA1 and BRCA2 genes is the highest during the ____.

Genes that turn off or decrease the rate of cell division are known as ____________________ genes.

Summarize two pathways to colon cancer.

Progressive chromosomal changes as cancer develops are related to the loss of the ability to repair ____________________ in cancer cells.

Stem cells have the ability to differentiate to form specific cell types,which divide only slowly or not at all.

Hereditary nonpolyposis colon cancers (HNPCC)____.

Give a possible interpretation of the finding that the number of mutational events that occur during the transition from normal to malignant cells is much larger than previously thought.

Most of the somatic cells in the body are structurally and functionally specialized and do not divide.

If a cell begins to divide in an uncontrolled way,it ____.

List four lines of evidence that support a link between cancer and genetics.Describe the ultimate cause of cancer and how an individual's life-style might reduce the chances of developing cancer.

Explain why epithelial cells are the source of 80% to 90% of all cancers.Then list at least two types of epithelial cells,and at least four types of cancer for which they are the source.

Stem cells ____.

Explain how the loss of heterozygosity (LOH)leads a cell to become cancerous.

The RB1 tumor-suppressor gene ____.

A reciprocal translocation between two chromosomes can result in the formation of a(n)____________________ gene.

When MSH2 and MLH1 are inactivated by mutation,DNA repair is defective and ____________________ mutation rates increase by at least 100-fold.

The field of epigenetics has opened the way for the development of a new class of anticancer drugs ____.

Hereditary nonpolyposis colon cancer (HNPCC)requires only one mutational step to initiate the formation of a cancer cell.

A Perspective on Human Genetics

Cells and Cell Division

Transmission of Genes from Generation to Generation

Pedigree Analysis in Human Genetics

The Inheritance of Complex Traits

Cytogenetics - Karyotypes and Chromosome Aberrations

Development and Sex Determination

The Structure - Replication - and Chromosomal Organization of DNA

Gene Expression and Gene Regulation

From Proteins to Phenotypes

Genome Alterations - Mutation and Epigenetics

An Introduction to Genetic Technology

Biotechnology and Society

Genomes and Genomics

Reproductive Technology - Genetic Testing - and Gene Therapy

Genes and The Immune System

Genetics of Behavior

Population Genetics and Human Evolution

Filters