Exam 5: Linkage, Recombination, and the Mapping of Genes on Chromosomes

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Which of the three genes, if any, is unlinked to the others?

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A dihybrid test cross is made between genes H and I.Four categories of offspring are produced: HI, Hi, hI, and hi.You wish to use the χ \chi 2 test to test the hypothesis that the H and I genes are unlinked.How many degrees of freedom would there be in this test?

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Sectors with a different phenotype in an otherwise uniform yeast colony may be evidence of mitotic recombination.

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In Drosophila, singed bristles (sn) and cut wings (ct) are both caused by recessive, X-linked alleles.The wild type alleles (sn+ and ct+) are responsible for straight bristles and intact wings, respectively.A female homozygous for sn and ct+ is crossed to a sn+ct male.The F1 flies are interbred.The F2 males are distributed as follows In Drosophila, singed bristles (sn) and cut wings (ct) are both caused by recessive, X-linked alleles.The wild type alleles (sn<sup>+</sup> and ct<sup>+</sup>) are responsible for straight bristles and intact wings, respectively.A female homozygous for sn and ct<sup>+</sup> is crossed to a sn<sup>+</sup>ct male.The F<sub>1</sub> flies are interbred.The F<sub>2</sub> males are distributed as follows   Of these 4 phenotypic classes of offspring, which of the following arose from a parental gamete produced by the F1 females? Of these 4 phenotypic classes of offspring, which of the following arose from a parental gamete produced by the F1 females?

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Suppose the L and M genes are on the same chromosome but separated by 100 map units.What fraction of the progeny from the cross LM/lm * lm/lm would be Lm/lm?

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The R/r and S/s genes are linked and 10 map units apart.In the cross Rs / rS * rs / rs what percentage of the progeny will be Rs / rs?

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If only 100 progeny had been counted and the same proportion observed, how would the p value and the conclusion drawn about linkage change?

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The Q gene locus is 10 map units from the R gene locus which is 40 map units from the S gene locus: Q--10 mu--R--40 mu--S Which interval would likely show the higher ratio of double to single chiasmata?

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