Question 1

Which of the following is not a piece of evidence that supports the radial loop-scaffold model of DNA packaging?

Accepted Answer

A) Histone-depleted metaphase chromosomes still maintain their X-like shapes. 
B) Electron micrographs of whole-mounted mitotic chromosomes show loops of chromatin at the periphery of the chromosomes. 
C) Topoisomerase II assists in 100Å packaging. 
D) Special, irregularly spaced repetitive base sequences associate with nonhistone proteins to define the chromatin loops. 
A) Histone-depleted metaphase chromosomes still maintain their X-like shapes. 
B) Electron micrographs of whole-mounted mitotic chromosomes show loops of chromatin at the periphery of the chromosomes. 
C) Topoisomerase II assists in 100Å packaging. 
D) Special, irregularly spaced repetitive base sequences associate with nonhistone proteins to define the chromatin loops.

Question 2

From DNA research, sites of transcription and therefore most of the genes along the length of the chromosome appear to be found in

Accepted Answer

A) heterochromatin. 
B) euchromatin. 
C) constitutive heterochromatin. 
D) centromeric regions. 
A) heterochromatin. 
B) euchromatin. 
C) constitutive heterochromatin. 
D) centromeric regions.

Question 3

Comparison of the chromosome banding pattern of humans and which other primate have banding patterns nearly identical on 13 of the chromosomes?

Accepted Answer

A) gorilla. 
B) chimpanzee. 
C) orangutan. 
D) baboon. 
A) gorilla. 
B) chimpanzee. 
C) orangutan. 
D) baboon.

Question 4

Telomeres appear to function in at least two ways during the replication of chromosomes.One way is to provide a primer for DNA polymerase.The second is to

Accepted Answer

A) allow the chromosome to shorten each generation to speed up replication. 
B) bind to telomerase. 
C) permit the hairpin turn at the end to be cleaved. 
D) carry genes needed for DNA replication. 
A) allow the chromosome to shorten each generation to speed up replication. 
B) bind to telomerase. 
C) permit the hairpin turn at the end to be cleaved. 
D) carry genes needed for DNA replication.

Question 5

At what stage of mitosis do we first see a chromosome that is compacted 250-fold over the 40-fold compacted 300Å fiber?

Accepted Answer

A) prophase 
B) metaphase 
C) anaphase 
D) telophase 
E) never achieves this level of compaction 
A) prophase 
B) metaphase 
C) anaphase 
D) telophase 
E) never achieves this level of compaction

Question 6

Which of the following is NOT true about DNA polymerase?

Accepted Answer

A) It cannot begin the 5' end of a new strand without a primer. 
B) It can only travel in the 5' to 3' direction. 
C) It can reconstruct the 3' end of each newly made DNA strand. 
D) It can replace RNA primer with DNA at the 5' end. 
A) It cannot begin the 5' end of a new strand without a primer. 
B) It can only travel in the 5' to 3' direction. 
C) It can reconstruct the 3' end of each newly made DNA strand. 
D) It can replace RNA primer with DNA at the 5' end.

Question 7

You treat a sample of DNA with DNAse and run the digested fragments out on an electrophoretic gel.You found mostly long fragments.What can you conclude about this sample of DNA?

Accepted Answer

A) The sample contains mostly euchromatin. 
B) The sample contains relatively few histone proteins. 
C) The sample contains mostly heterochromatin. 
D) The sample cannot be digested by DNAse. 
E) The sample likely represents actively transcribed genes. 
A) The sample contains mostly euchromatin. 
B) The sample contains relatively few histone proteins. 
C) The sample contains mostly heterochromatin. 
D) The sample cannot be digested by DNAse. 
E) The sample likely represents actively transcribed genes.

Question 8

FISH analysis is useful for determining the

Accepted Answer

A) order of DNA fragments in a BAC. 
B) pattern of expression of a cloned gene. 
C) chromosomal location of a gene. 
D) map order of two closely linked genes. 
A) order of DNA fragments in a BAC. 
B) pattern of expression of a cloned gene. 
C) chromosomal location of a gene. 
D) map order of two closely linked genes.

Question 9

What is the best definition for the FISH technique?

Accepted Answer

A) A method to fluorescently label different genes on metaphase chromosomes. 
B) A method to fluorescently label different chromnosomes during metaphase. 
C) A method to fluorescently label heterochromatin.. 
D) A method to fluorescently label euchromatin.. 
A) A method to fluorescently label different genes on metaphase chromosomes. 
B) A method to fluorescently label different chromnosomes during metaphase. 
C) A method to fluorescently label heterochromatin.. 
D) A method to fluorescently label euchromatin..

Question 10

In mammalian cells, replication proceeds

Accepted Answer

A) unidirectionally 
B) bidirectionally. 
C) unidirectionally from many origins. 
D) bidirectionally from only one origin. 
A) unidirectionally 
B) bidirectionally. 
C) unidirectionally from many origins. 
D) bidirectionally from only one origin.

Question 11

The first level of compaction of DNA consists of

Accepted Answer

A) DNA winding around histones to form small nucleosomes. 
B) tight coiling of DNA with nucleosomes into higher order structures. 
C) high level compaction into metaphase-type chromosomes. 
D) histone, DNA, and nonhistone covalent bonding. 
A) DNA winding around histones to form small nucleosomes. 
B) tight coiling of DNA with nucleosomes into higher order structures. 
C) high level compaction into metaphase-type chromosomes. 
D) histone, DNA, and nonhistone covalent bonding.

Question 12

The histone that appears to be responsible for organizing the 100 Å fibers into 300 Å fibers is

Accepted Answer

A) H4. 
B) H3. 
C) H2. 
D) H1. 
A) H4. 
B) H3. 
C) H2. 
D) H1.

Question 13

Which of the following is not a role ascribed to nonhistone proteins found in chromatin?

Accepted Answer

A) structural 
B) replication 
C) chromosome segregation 
D) nucleosome packers 
A) structural 
B) replication 
C) chromosome segregation 
D) nucleosome packers

Question 14

In higher eukaryotes, kinetochores attach to

Accepted Answer

A) one spindle fiber. 
B) one spindle fiber on each side. 
C) multiple spindle fibers. 
D) multiple repeating structural subunits. 
A) one spindle fiber. 
B) one spindle fiber on each side. 
C) multiple spindle fibers. 
D) multiple repeating structural subunits.

Question 15

In which of the following cases will a Barr body be seen?

Accepted Answer

A) only XX 
B) XY 
C) XO 
D) only XXY 
E) both XX and XXY 
A) only XX 
B) XY 
C) XO 
D) only XXY 
E) both XX and XXY

Question 16

During development, an XX female embryo will form one of the X chromosomes in each cell into a Barr body.This usually occurs

Accepted Answer

A) about two weeks after zygote formation. 
B) by the end of the first trimester. 
C) at the 16-cell stage. 
D) in the X that is the most recessive. 
A) about two weeks after zygote formation. 
B) by the end of the first trimester. 
C) at the 16-cell stage. 
D) in the X that is the most recessive.

Question 17

With regard to the typical human cell, which of the following appears to be true?

Accepted Answer

A) There is only one origin of replication. 
B) There are multiple origins of replication that function consecutively. 
C) There are multiple origins of replication that function simultaneously. 
D) Replication is not understood well enough to postulate on replication origins. 
A) There is only one origin of replication. 
B) There are multiple origins of replication that function consecutively. 
C) There are multiple origins of replication that function simultaneously. 
D) Replication is not understood well enough to postulate on replication origins.

Question 18

When a chromosomal rearrangement such as an inversion occurs placing a known gene into or next to a heterochromatic region, the gene's expression

Accepted Answer

A) will turn on. 
B) may be amplified. 
C) may cease. 
A) will turn on. 
B) may be amplified. 
C) may cease.

Question 19

Cohesins are a multisubunit protein complex that functions to

Accepted Answer

A) hold sister chromatids together. 
B) ensure that proper chromosome arm length is maintained. 
C) allow easy karyotyping. 
D) develop meiotic chromosome replication. 
A) hold sister chromatids together. 
B) ensure that proper chromosome arm length is maintained. 
C) allow easy karyotyping. 
D) develop meiotic chromosome replication.

Question 20

Yeast research with autonomously replicating sequences (ARS), along with digestion of chromatin with DNase I, have led scientists to determine that

Accepted Answer

A) DNA is not protected inside a nucleosome. 
B) ARSs are really plasmids. 
C) ARSs bond irreversibly to replication enzymes. 
D) origins of replication are accessible regions of DNA devoid of nucleosomes. 
A) DNA is not protected inside a nucleosome. 
B) ARSs are really plasmids. 
C) ARSs bond irreversibly to replication enzymes. 
D) origins of replication are accessible regions of DNA devoid of nucleosomes.

Exam 11: The Eukaryotic Chromosome

Which of the following is not a piece of evidence that supports the radial loop-scaffold model of DNA packaging?

From DNA research, sites of transcription and therefore most of the genes along the length of the chromosome appear to be found in

Comparison of the chromosome banding pattern of humans and which other primate have banding patterns nearly identical on 13 of the chromosomes?

Telomeres appear to function in at least two ways during the replication of chromosomes.One way is to provide a primer for DNA polymerase.The second is to

At what stage of mitosis do we first see a chromosome that is compacted 250-fold over the 40-fold compacted 300Å fiber?

Which of the following is NOT true about DNA polymerase?

You treat a sample of DNA with DNAse and run the digested fragments out on an electrophoretic gel.You found mostly long fragments.What can you conclude about this sample of DNA?

FISH analysis is useful for determining the

What is the best definition for the FISH technique?

In mammalian cells, replication proceeds

The first level of compaction of DNA consists of

The histone that appears to be responsible for organizing the 100 Å fibers into 300 Å fibers is

Which of the following is not a role ascribed to nonhistone proteins found in chromatin?

In higher eukaryotes, kinetochores attach to

In which of the following cases will a Barr body be seen?

During development, an XX female embryo will form one of the X chromosomes in each cell into a Barr body.This usually occurs

With regard to the typical human cell, which of the following appears to be true?

When a chromosomal rearrangement such as an inversion occurs placing a known gene into or next to a heterochromatic region, the gene's expression

Cohesins are a multisubunit protein complex that functions to

Yeast research with autonomously replicating sequences (ARS), along with digestion of chromatin with DNase I, have led scientists to determine that

Genetics: The Study of Biological Information

Mendels Principles of Heredity

Extensions to Mendels Laws

The Chromosome Theory of Inheritance

Linkage, Recombination, and the Mapping of Genes on Chromosomes

DNA Structure, Replication, and Recombination

Anatomy and Function of a Gene: Dissection Through Mutation

Gene Expression: The Flow of Information From DNA to RNA to Protein

Digital Analysis of Genomes

Analyzing Genomic Information

Chromosomal Rearrangements and Changes in Chromosome Number

Bacterial Genetics

Organellar Inheritance

Gene Regulation in Prokaryotes

Gene Regulation in Eukaryotes

Manipulating the Genomes of Eukaryotes

The Genetic Analysis of Development

The Genetics of Cancer

Variation and Selection in Populations

Genetics of Complex Traits

Filters